internal medicine
👨⚕ Q. What is the CML?
🧑⚕A. It is a myeloproliferative disorder, characterized by overproduction of myeloid cells and presence of Philadelphia chromosome. It is common in 40 to 60 years, and peak age is 55 years.
internal medicine
👨⚕How to differentiate between acute and chronic Leukemia ?
🤔What is leukaemic hiatus??
internal medicine
🤔What is leukaemic hiatus??
Answer:
the presence of blasts and mature leukocytes but no intermediate forms
the presence of blasts and mature leukocytes but no intermediate forms
internal medicine
👨⚕ what is Leukemia cutis ?
Answer:
Leukemia cutis is the infiltration of neoplastic leukocytes or their precursors into the epidermis, the dermis, or the subcutis, resulting in clinically identifiable cutaneous lesions
Leukemia cutis is the infiltration of neoplastic leukocytes or their precursors into the epidermis, the dermis, or the subcutis, resulting in clinically identifiable cutaneous lesions
internal medicine
👨⚕What is Philadelphia chromosome ?
Excellent answer in comments
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Your opinion ?
Your opinion ?
internal medicine
👨⚕What is Philadelphia chromosome ?
🧑🏽⚕Answer :Reciprocal translocation
between chromosome 9 and chromosome 22 → formation of the Philadelphia chromosome t(9;22) → fusion of the ABL1 gene (chromosome 9) with the BCR gene (chromosome 22) → formation of the BCR-ABL gene → encodes a BCR-ABL non-receptor tyrosine kinase with increased enzyme activity
Result: inhibits physiologic apoptosis and increases mitotic rate → uncontrolled proliferation of functional granulocytes
MalignancyDetection of Philadelphia translocationCML
> 90% of patients
ALL
∼ 20% of adults
∼ 5% of children
AML
< 2% of patients
between chromosome 9 and chromosome 22 → formation of the Philadelphia chromosome t(9;22) → fusion of the ABL1 gene (chromosome 9) with the BCR gene (chromosome 22) → formation of the BCR-ABL gene → encodes a BCR-ABL non-receptor tyrosine kinase with increased enzyme activity
Result: inhibits physiologic apoptosis and increases mitotic rate → uncontrolled proliferation of functional granulocytes
MalignancyDetection of Philadelphia translocationCML
> 90% of patients
ALL
∼ 20% of adults
∼ 5% of children
AML
< 2% of patients
internal medicine
👨⚕Q. What are the myeloproliferative disorder?
🧑⚕ Answer :
Group of disease consisting of:
1- Chronic myelocytic leukemia
2- Myelofibrosis
3- Polycythemia rubra vera
4- Essential thrombocythemia.
These disorders are grouped together, because any of the disease may evolve from one form to another.
All myeloproliferative disorders may progress to acute myeloid leukemia
Group of disease consisting of:
1- Chronic myelocytic leukemia
2- Myelofibrosis
3- Polycythemia rubra vera
4- Essential thrombocythemia.
These disorders are grouped together, because any of the disease may evolve from one form to another.
All myeloproliferative disorders may progress to acute myeloid leukemia