Drug of Choice of mild malaria is CoArtem ..

Drug of Choice of Severe malaria is artesunate , the alternative is Quinine + Doxycycline

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شرح الدكتور أمين عبدالرب :-

علاج ال Cerebral malaria :-
Quinine
Artesenate
Arthemeter

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Quinine in Glucose infusion ( 5% )
10 mg / kg > 3×1 ( during 4 hours )

لانه نخاف من ال Arrhythmia
وفي Glucose لانه يعمل Hypoglycemia

و repeat every 8 hours
For 6 days .

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After finishing

Doxycycline, of fansidar

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Arthemeter : fat soulable ( I.M )

Artesunate :- water soluble ( Anti- schistosoma)

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Primaquine >>> Anti- gametocye for community eradication

Induce Heamolysis / agranyloctosis

( vivax / ovale >> in hypnotic stage )

لكن اليمن صارت Resistance لهذا ما عاد يستخدموه .

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Mild malaria , moderate :-

Combination for 3 days

Quartam ( Artemether/lumefantrine)
:- 4 tablets / 2 / 3
احسن علاج و مافيش side effect زيادة

Malarone (Atovaquone/proguanil )
:- 2 ×2 ×3

Of Fansidar + artesenate

Or Fansidar + Mefloquine

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Fansidar side effects :-

Bone marrow depression

Steven Johnson syndrome ( as a hypersensitivity reaction)

#malaria
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High Anion Gap Metabolic acidosis

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Drugs may cause Bradycardia.

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First-line medications for primary hypertension are thiazide diuretics, ACEIs, ARBs, and CCBs.

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Do not prescribe an ACEI and ARB together or in combination with a direct renin inhibitor. This increases the risk of hyperkalemia and renal dysfunction and does not provide additional benefit.

Diagnosis of hepatorenal syndrome .

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+ hyponatremia
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