🛑 Note :

❗️DNA viruses may be Oncogenic

🛑Cervical cancer may be due to :-
1- HSV-2
2- HPV ( 16,18,6,11 )

🛑 Keratoconjunctivitis:-
By :-
1- HSV-1
2- Adenoviruses

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📛 Exanthematic Diseses: 6

( MS.VRPR)

1- M : measles by Rubeloa virus
2-S : scarlet fever by erythrogenic toxins of Streptococcus pyogens
3-V: Vericella by VSV
4- R: rubella
5- P: Parvovirus b19 , slapped Cheek appearance ( fifth disease)
6-R: Roseola Infantum ( Sixth disease) by HHV-6/7

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💉 Summary of DNA viruses prevention :-

🌺 Herpsviridae:-

1- HSV-1 :-
a) Avoid contact with herpetic lesions
b) Avoid kissing
c) hand washes
d) personal purposes

2- HSV-2 :-
a) Avoid Adultery
b) Cesarean section for new born

2- VZV :- ( Active / Passive immunization)
🍃a) Active:-
❗️For Vericella: 1995 children
Varivax >> Live attenuated >> 2Doses

❗️ For Zoster : old age
a) Zostavax (2006 ) >> live attenuated >> single ... over 60y
b) Shingrix ( 2017 ) >> recombinant

🍃 Passive:-
( VZIG )
Immunoglobulin for Immunocompromized , mother before delivery , neonatel


3) EBV :
a) Avoid kissing
b) vaccine under trail

4) CMV :-
a) blood transfusion free of CMV
b) Donor and recipient of organ Transplant free of CMV
c) vaccine under trial
2018 positive phase1

🌺 Poxviruses : no vaccine

🌺 Adenoviruses:
a) Avoid overcrowded
b) hand washing
C) chorination of Swimming pool
d) vaccne type 3,4&7 which was ceased ( Stopped ) 1999

🌺 Papovavirus:-
1- human Papilloma virus prevention:
a) Quadrivalent (6,11,16,18 ) for female ( 0 , 2 & 6 months )
b) Bivalent ( Cervarix) for Type 16,18 ( Recombinant)

🌺 Parvovirus B19:-
a) Screening of Blood transfusion for patients with chronic anemia , AIDS , anemic pregnant women
b) Vaccine ( 0 ,1 &6 ) recombinant

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🛑 Note for the DNA viruses we have vaccines for 4 Viruses only :-

1- VZV
2- Adenoviruses ( Stopped )
3- human Papilloma virus
4- Parvovirus


And for EBV ,CMV :- Vaccines under trail

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🙂🙂🙂
For
HSV-1
HSV-2
VZV
Direct virus demonstration:
By scrapping the ulcer of from Vesicular fluids
Under light microscope:-
Tzanck smear
Shows ( Multinucleated Gaint cells )
Stained by Geimsa stain

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Most commonly:

Laboratory diagnosis methods used :-

1) PCR
2) Viral atigens by DIF

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🤕 common skin rashes :-

1- macule : small ,flat
2- papule : small ,raised ( solid)
Maculopapule Both^
3- vesicle : small , elevated ( with clear fluid)
4- pastule : vesicle filled with pus
5- Nodule: large , raised, Solid


🤕 Differences between Droplets / Airborne :-

Droplets : Large >5 microns
Surface contamination
Removed by hand wash

Airborne:- smaller ( Droplet nuclei )
<5 microns
Still in the air ( more dangerous)

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🤔For EBV :

Anti - VCA IgM / IgG :- Anti viral capsid

IgM :- Acute infection then disappears
IgG ; may be Occurs in Acute infection, remains in convalescent


anti-EBNA IgG ( EB nuclear antigen)
Only occur in convalescent and indicates previous infection

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🛑 Lymphocytosis is suspected lymphoma utill proven otherwise ..

🛑 Lymphocytosis with Atypical T lymphocytes ..." feel safe "
It is infectioue Mononucleosis

🛑 to Differentiate between infectioue Mononucleosis, and Infectious mononucleosis like syndrome

Infectious mononucleosis, With heterophills Antibodys in EBV

Infectious mononucleosis like, without Hetrophills antibodies in CMV

Both shows symptoms of:
Sore throat, fever , fatigue, lymphadenopathy , enlarged spleen , Hepatitis

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🍃Why small pox is eridicated:-

1- it has only one stable stereotype.
2- The man is the only host
3- no reservoir host
4- no carrier
5- was the first to be controlled by vaccine
6- produce long lasting memory

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🤔🤔 Small pox and Chickenpox:

Both are transmitted by droplets and contact ..

Small pox
❗️Caused by small pox viruse
❗️Rash :- centrifugal
❗️Starts : macule , papule , vesicle , pustules, ends forming crust
❗️Scar formation ..
And Fetal


Chicken pox :
❕ caused by VZV
❕ rash : Centripetal
❕ polymorphic ( all in same time )
Characterized by Umblicated lesion
❕ healed without scar
Not fetal

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🤔 Molliscum contagiosm and Human Papilloma warts

Molliscum contagiosm:-
❗️ Caused by MCV , Poxviruse
❗️ one genotype
❗️ Umblicated cheesy Papules
❗️ soft
❗️ called Human soft warts

Human Papilloma wart : -
❗️ Caused by HPV , Papovaviruses
❗️>100 serotypes
❗️ cauliflower shaped ( Verruca Vuligaris)
❗️ rough
❗️called warts ( Verruca)

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🛑HPV cannot be caltivated in vitro

🛑 virus that transmitted through birth canal :- HSV- 2

🛑 Human Papilloma virus:
Causes cervical carcinoma with genotype 16 ,18 ?
Because the virus produce oncoproteins integrated on DNA
E6 binds to P53
E7 Binds to Rb
Inactivation of This Tumor suppressor genes , Increase mitosis, tumor

🛑 there is some strains of small pox with America and Russia, they may use them in the Bio terrorism.

🛑 Oncolytic viral therapy is a new strategy by which ... There are Viral strains that kill the malignant cells , And stimulate the Immune system ?
How ?
When this virus infect the Tumor , it replicates itself untill the cell burst , ( Lysis of Tumor ) then the product of Bursting tumor cell initiate the immune response !

🛑 Hydrops fetalis may be
Because , infant infected by Parvovirus B19 , Or due to RH incompatibility

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هنا مكتوبات مثل الملزمة..

بس الدكتور عكس بينهم

Jc : Progressive multifocal Luekoencephalopathy

Bk: Heamorrhagic Cystitis, Nephropathy

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جدول ملخص الملخص ترم اول وثاني فارما محاضرات الدكتور عدنان.
Disease + Drug of choice

Brain-mab
لاغلب الاقسام

Schiller–Duval body is a cellular structure seen by microscope in endodermal sinus tumors (yolk sac tumors) characterized by the presence of a central vessel, surrounded by epithelial tumor cells and fibrous tissue
#باثو
#الدكتورة_منية

🥛Milk-alkali syndrome 🥛

is caused by the ingestion of large amounts of calcium and absorbable alkali, with resulting hypercalcemia. ... This syndrome was originally recognized in the 1920s during administration of the Sippy regimen, consisting of milk and bicarbonate, for treatment of peptic ulcer disease.( CaCo3)


Burnett's syndrome is far-advanced milk-alkalisyndrome and due to long-standing calcium and alkali ingestion. It is characterised by severe hypercalcaemia, irreversible renal failure, and phosphate retention. ... The patient is treated by withdrawal of excessive calcium and alkali intake.


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مواضيع :-

anticancer , anticoagulant , antiplatelet & hyperlipidemia
D.M

حالي علشان اختبار الشفوي بس يلم الموضوع والمراجعة اللي هي صبح الإختبار


#فارما 💛