⭕ Diagnosis: Gastric adenocarcinoma

🔶 Feature: Eosinophilic glands invading the musclaris propria (may also invade other layers and other abdominal organs)

⭕ Diagnosis: Diffuse gastric adenocarcinoma (Signet ring carcinoma)

🔶 Feature: Signet ring cells with abundant cytoplasm

⭕ Diagnosis: Neuroendocrine tumor (Carcinoid tumor)

🔶 Feature: Nests of cells, the nuclei of the cells are characterized by the presence of light and dark chormatin "Salt and Pepper nuclear chromatin"

⭕ Diagnosis: Gastrointestinal stromal Tumor (GIST) may be benign or malignant

🔶 Feature: the presence of :-
-Spindle shaped cells (the arrow in the 1st picture) or Vacuoles which indicates cells with clear cytoplasm (the arrow in the 2nd picture)

⭕ Diagnosis: Lymphoma

🔶 Feature:
1-Lympho-Epithelial lesion, it contains clusters of lymphocytes (5 to 6) inside the epithelium of the glands.
2-Diffuse lymphocytes in the whole section.


Note: Lymphoma should be differentiated from chronic inflammation.
- In inflammation only one lymphocyte may present in the lesion with a lot of neutrophils.

⭕ Diagnosis: Lymphoma

🔶 Feature:
-Atypical lymphocytes with little cytoplasm (normally lymphocytes have no cytoplasm) arranged in a rossette pattern.
#معمل_باثو
#سلايدات

⭕ Normal small intestine

🔶 Feature: Villi (finger like projections used for absorption)

⭕ Large intestine (longitudinal and horizontal sections)

🔶 Feature: Crypts

⭕ Ganglion cells "found inside the nerve bundle"

🔶 Feature: Large cells with basophilic cytoplasm and eccentric nucleus. (Arrow)

⭕ Diagnosis: Crohn's Disease (CD)
It is an inflammation that includes all layers of the GIT (mucosa, submucosa, musclaris propria and serosa). It occurs mostly in the terminal ileum.

🔶 Feature:
-Not all Parts of the mucosa are affected, there are some skip lesions.
-liner ulcers (grooves) and normal mucosa in between the ulcers
-round ulcers

⭕ Diagnosis: Crohn's Disease
(gross and microscopic)
🔶 Feature:
-Fissuring
-The previously mentioned features

⭕ Diagnosis: Crohn's Disease

🔶 Feature:
-Cobblestone appearance:-
The grooves are the ulcerated parts in between them the normal parts (skip lesions).

⭕ Diagnosis: Crohn's Disease (microscopic)

🔶 Feature: 1st picture shows the skip lesions 2nd picture shows Inflammatory cells in all wall layers

⭕ Diagnosis: Crohn's Disease

🔶 Feature: Granuloma (arrows)

⭕ Diagnosis: Ulcerative Colitis (UC)
It is an inflammation that usually affects the mucosa and may reach the submucosa of the large intestine.

🔶 Feature:
-Inflammatory pseudopolyps (the polyps are formed from the aggregating lymphocytes)
-No skip lesions (the whole layer is ulcerated)

⭕ Diagnosis: Ulcerative Colitis (microscopic)

🔶 Feature:
-Crypt abscess (aggregation of neutrophils)
-The whole thickness of the mucosa is inflamed

⭕ Diagnosis: Familial Polyposis Coli (FPC)

🔶 Feature: The presence of Adenomatous polyps:-
-Scattered polyps with normal mucosa (Picture B)

-Multiple polyps (Pre-cancerous) covering the whole section (Picture D)

⭕ Diagnosis: FPC "Adenoma" under the microscope

🔶 Feature:
Dysplastic changes:-
1- Hyperchromatic cells present in different levels
2-Stratification

كذا نكون وصلنا لآخر محطة في مراجعتنا لمعمل الباثو،

نحيي من شغاف القلب أعضاء مجموعة الباثو وكل من ساهم معانا تحية تقدير لجهدهم ودأبهم ونشاطهم وتفانيهم،

جزاهم الله خيرا وأعلى الله قدرهم ورفع منزلتهم وبارك لهم في أوقاتهم،

نلفت أيضا، إنه،

*عينزل ملف يجمع كل المراجعات السابقة من تجميع الغيث/هاشم السواري،
وعيراجعه الدكتور وضاح ع أن يكون بين أيديكم قبيل موعد الإختبار،

*معمل الكانسر ما وصلناش حقه الpdf،
وقال الدكتور عيضيف لنا سلايدات وقت ما يراجع لنا الملف،

*عنجمع كل المراجعات السابقة- "معدلة" بحسب مراجعة الدكتور- مع الشروح لمن يحب يستفيد منها في قناة خاصة،

والله ولي التوفيق،

و لا تنسونا من خالص دعائكم،

⚫️ Pathology lab Index:

-cell injury:
https://t.me/batch34notes/984

- Inflammation:
https://t.me/batch34notes/1052

- Repair:
https://t.me/batch34notes/1090

- Hemodynamic :
https://t.me/batch34notes/1102

- Immunpathology :
https://t.me/batch34notes/1178

- Genetics :
https://t.me/batch34notes/1214

- Slides of Last lecture "Eams's example" :
https://t.me/batch34notes/1348

- Vascular pathology :
https://t.me/batch34notes/1367

- CVS pathology :
https://t.me/batch34notes/1396

- Respiratory System pathology :
https://t.me/batch34notes/1459

- GIT pathology :
https://t.me/batch34notes/1499

أضغط على الرابط و بتوصل على مقدمة كل موضوع انشرح .

نتقدم بخالص العزاء والمواساة لزميلتنا / زهراء عبدالحكيم الشعيبي في وفاة المغفور لها بإذن الله أختها 💔
سألين من الله عز وجل ان يرحمها ويغفر لها ويسكنها في اعلى مراتب الفردوس الاعلى مع الصديقين والشهداء
وان يلهم اهل وذويها الصبر والسلوان و يثبتهم ويعصم قلوبهم بهذا المصاب الجلل
وإنا لله وإنا إليه راجعون 😭💔