✨ Cell Necrosis ✨ :

Types :

🔥1 - Coagulative Necrosis:
( Dead Cell without nucleus - still has its architecture)
Without losing the outline of the cell

اللي بيحصل مثل ما قلنا Hypoxia ..
فتلجأ الخلية لل Anerobic energy واللي بتؤدي الى تكوين وتراكم ال lactic acid داخل الخلية واللي بيغير الوسط فيها الى حمضي Acidic هذا الكلام بيؤدي الي denaturation of proteins .. فتموت الخلية و تتوقف الانزيمات عن العمل ..قبل مايحصل لها Autolysis .. فننتظر لل Phagocytosis يخلصنا منها ..

🔥2- Liquifactive necrosis:-
( Lose Of tissue architecture >> replaced by fluid )

Ischemia of Brain
ومثل ما احنا عارفين ال Brain ما يقدر يعيش من غير Oxygen .. ما بيسوي Anerobic ومافيش لاكتيك Acid
بالتالي ال Autolysis of the Cell

🔥3- Caseous Necrosis :-

Gross : yalloe cheese appearance
وعارفين جدا اول ما نسمع عن ال Caseous Necrosis على طول يجيب في بالنا ال TB
Microscopicall :
Lose of Architecture
بنشوف منطقة ال Necrosis على هيئة
Acellular -esionphilc
Surrounded by Granulomatous inflammation

🔥 Fat Necrosis:
نتيجة ال Abnormal metabolism of fat
بنشوفها في ال Pancreas / Breast
Gross: White shalk appearance ( Saponification )

Microscopically:- Outline of cell is perserved >>> Fat accumulation + Ca
( Clacification)

🔥 Fibrinoid Necrosis :
Necrosis >> In Blood Vessels

Charecteriszed by Fibrin deposition
>> Esionphilc amorphus appearance

🔥 Gangrenous Necrosis:-
Necrosis with puterification
Mix all Type of Necrosis

#معمل_باثو
#مجموعة_الباثو
#اللجنة_العلمية
@batch34notes

❗️Diagnosis:-
Area of Infarction of Kidney ( Coagulative Necrosis) Gross

❗️Characteristic features:-
Infarct yellow area with perserved outline

#معمل_باثو
#سلايدات

❗️Diagnosis:
Coagulative Necrosis of the Liver

❗️Characteristic features:-
Dead cell ( Without nucles) without losing their Architecture ( Cell outline)
#معمل_باثو
#سلايدات

❗️Diagnosis:
Gross picture of Liquifactive necrosis of the Brain.

❗️Characteristic features:
Loss of Tissue architecture
Replaced by fluid-filled sacs due to lysosmoal enzymes action

#معمل_باثو

❗️Diagnosis:-
Liquifactive necrosis Microscopically

❗️Characteristic features:-
Cystic space containing cell debris

#معمل_باثو
#سلايدات

❗️Diagnosis :
Caseous Necrosis of TB in lung

❗️Characteristic features:-
Cheese like appearance of lung ( Gross)
#معمل_باثو
#سلايدات

❗️Diagnosis :
Caseous Necrosis of TB in lung

❗️Characteristic features:-
Cheese like appearance of lung ( Gross)
#معمل_باثو
#سلايدات

❗️Diagnosis :
Caseous Necrosis of TB in lung

❗️Characteristic features:-
area of Acellular, amorphus, esionphilc , Heamogenous , surrounded by Granulomatous inflammation.
#معمل_باثو
#سلايدات

❗️Diagnosis:
Fat Necrosis ( Due to acute Pancerititis )

❗️Characteristic features:-
White shalk appearance ( Saponification)

#معمل_باثو
#سلايدات

❗️Diagnosis:
Fat Necrosis Microscopically

❗️Characteristic features:
Necrosis of far cell with perserved outline of the cell + Calcification (Ca Deposition)
#معمل_باثو
#سلايدات

لاحظ الفرق بين :
Fat accumulation, Far Necrosis

Fat necrosis with Ca Deposition

#معمل_باثو
#سلايدات

Fat Accumulation

Fat necrosis

هنا شوفوا كيف يكون ال Calcification

اليمين مع ال Fat Necrosis

اليسار مع ال Caseous Necrosis of lymph node

#معمل_باثو
#سلايدات

❗️Diagnosis:
Fibrinoid Necrosis of Glomeruli.

❗️Characteristics features:-
Fibrin Deposition in the wall of Blood vessels ( Esionphilc amorphus appearance)

#معمل_باثو
#سلايدات

So sorry

❗️Diagnosis :
Gangrenous Necrosis

❗️Characteristic features:
Necrosis with puterification

#معمل_باثو
#سلايدات

فرقنا اول بين ال Apoptosis/ Necrosis


❗️Diagnosis:
Apoptosis of cell

❗️Characteristic features:-
Individual cell death ( Shrink ) with no inflammation

#معمل_باثو
#سلايدات

✨Lastly:

موضوع ال Accumulation

تكلمنا عن ال Hydropic/ Fat accumulation وال Calcification انو يترسب ال Ca ..
و ال Lipid and Protein accumulation

طيب ؟؟

باقي عندي مواد ممكن تتراكم في حالات معينة ولها صور مميزة

-🎃 Mallory Bodies :-
Red Globular Materials
In Damaged Liver cells Due to Alcoholism

🎃 Neurofibrilly tangles
Elongated pink tangles
In neurons of patient with Alzheimer's diseses

🎃Lewy Bodies :-
Abnormal aggregate of Proteins inside cell
In Dementia

🎃lipufusin :-
Pegment
In old cardiac muscle by Age

#معمل_باثو
#مجموعة_الباثو
#اللجنة_العلمية
@batch34notes

❗️Diagnosis:
Alcoholic Liver damage

❗️Characteristic features:-
Mallory Bodies ( Red Globular Materials)

#معمل_باثو
#سلايدات

❗️Diagnosis:
Alzheimer's diseses

❗️Characteristic features:-
Pink Elongated Neurofibrilly tangles

#معمل_باثو
#سلايدات

❗️Diagnosis:
Damage of Nuerons >> most likely dementia

❗️Characteristic features:-
Lewy bodies ( ubnormal intracellular esionphilc material ( Protein ))

#معمل_باثو
#سلايدات