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A 57-year-old man presents with hematuria and is diagnosed with renal cell carcinoma. Treatment with high-dose interleukin-2 (IL-2) leads to significant tumor regression. What mechanism likely contributed to this outcome?
Anonymous Quiz
14%
Antiangiogenic effect of IL-2
18%
Direct damage to tumor cells by IL-2
43%
IL-2 binding to Fe receptors on cytotoxic lymphocytes
25%
Enhanced activity of natural killer cells
Forwarded from Doctopia
In calculating an aminoglycoside dose for a 58-year-old male with type 2 diabetes, recurrent UTIs, and significant obesity, why would the pharmacy use an adjusted body weight rather than his actual weight?
Anonymous Quiz
18%
Elimination of the drug is predominately by hepatic clearance
36%
Distribution of the drug is limited to the extracellular fluid compartment\
19%
The drug exhibits a high degree of plasma protein binding
27%
The drug is tightly sequestered within adipose tissues
Forwarded from Doctopia
A 40-year-old woman with a history of pulmonary arterial hypertension (PAH) is prescribed sildenafil. Which of the following is the MOST LIKELY mechanism of action of sildenafil in PAH?
Anonymous Quiz
7%
Endothelin receptor antagonism
70%
Inhibition of phosphodiesterase-5 (PDE-5)
4%
Prostacyclin antagonism
18%
Vasodilation via antagonism of alpha-adrenergic receptors
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Forwarded from NEETPG || FMGE || INICET || MCQs By Doctopia.in
Patient with inflammatory bowel disease (IBD) presents with recurrent urinary tract infections and pneumaturia. Which of the following is the most likely explanation?
Anonymous Quiz
53%
Enterovesical fistula
24%
Pyelonephritis
16%
Interstitial cystitis
6%
Nephrolithiasis
Forwarded from NEETPG || FMGE || INICET || MCQs By Doctopia.in
A 70-year-old man presents with exertional dyspnea, angina, and syncope. Auscultation reveals a harsh systolic murmur at the right 2nd intercostal space, radiating to the carotids. What is the most likely diagnosis?
Anonymous Quiz
15%
Mitral regurgitation
62%
Aortic stenosis
8%
Mitral stenosis
15%
Aortic regurgitation
Forwarded from NEETPG || FMGE || INICET || MCQs By Doctopia.in
A 50-year-old with a history of MI presents with exertional dyspnea and fatigue. A holosystolic, high-pitched murmur is heard at the apex, radiating to the axilla. What is the most likely diagnosis?
Anonymous Quiz
12%
Aortic stenosis
24%
Mitral stenosis
59%
Mitral regurgitation
5%
Tricuspid regurgitation
Forwarded from Doctopia