🧬 AI just made proteins that can turn back cellular aging 50× faster
OpenAI created proteins that rejuvenate cells 50× more effectively
OpenAI, together with Retro Biosciences, developed a new model — GPT-4b micro — designed for protein engineering.
The model helped create new variants of the Yamanaka factors — proteins that turn ordinary cells into stem cells.
Result: a 50-fold improvement in reprogramming efficiency compared to natural proteins.
The new proteins, RetroSOX and RetroKLF, differed from the originals by over 100 amino acids, yet worked better in 30–50% of cases.
Most importantly — they showed improved ability to repair DNA damage, which is directly linked to cellular rejuvenation.
In experiments on human fibroblasts from donors over 50, within just 7 days more than 30% of cells began expressing pluripotency markers.
Forget Ozempic. In a couple of years, we might be injecting lifespan extensions instead.
Like in the movie In Time.
Let’s just hope it doesn’t end like The Substance. :)
#OpenAI #Longevity #Biotech
@science
OpenAI created proteins that rejuvenate cells 50× more effectively
OpenAI, together with Retro Biosciences, developed a new model — GPT-4b micro — designed for protein engineering.
The model helped create new variants of the Yamanaka factors — proteins that turn ordinary cells into stem cells.
Result: a 50-fold improvement in reprogramming efficiency compared to natural proteins.
The new proteins, RetroSOX and RetroKLF, differed from the originals by over 100 amino acids, yet worked better in 30–50% of cases.
Most importantly — they showed improved ability to repair DNA damage, which is directly linked to cellular rejuvenation.
In experiments on human fibroblasts from donors over 50, within just 7 days more than 30% of cells began expressing pluripotency markers.
Forget Ozempic. In a couple of years, we might be injecting lifespan extensions instead.
Like in the movie In Time.
Let’s just hope it doesn’t end like The Substance. :)
#OpenAI #Longevity #Biotech
@science
OpenAI
Accelerating life sciences research
Discover how a specialized AI model, GPT-4b micro, helped OpenAI and Retro Bio engineer more effective proteins for stem cell therapy and longevity research.
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