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Aldo Lorenzetti M.D, Internal Medicine & Hepatology, Milano - SIMEDET Delegate
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Patterns of #Sedentary Behavior and #Mortality in U.S. Middle-Aged and Older Adults: A National Cohort Study
http://annals.org/aim/article/2653704/patterns-sedentary-behavior-mortality-u-s-middle-aged-older-adults

Excessive sedentary time is ubiquitous in Western societies. Previous studies have relied on self-reporting to evaluate the total volume of sedentary time as a prognostic risk factor for mortality..

Sedentary time was measured using a hip-mounted accelerometer. Prolonged, uninterrupted sedentariness was expressed as mean sedentary bout length. Hazard ratios (HRs) were calculated comparing quartiles 2 through 4 to quartile 1 for each exposure (quartile cut points: 689.7, 746.5, and 799.4 min/d for total sedentary time; 7.7, 9.6, and 12.4 min/bout for sedentary bout duration) in models that included moderate to vigorous physical activity

Evaluation of their joint association showed that participants classified as high for both sedentary characteristics (high sedentary time ≥12.5 h/d and high bout duration ≥10 min/bout) had the greatest risk for death

Both the total volume of sedentary time and its accrual in prolonged, uninterrupted bouts are associated with all-cause mortality, suggestive that physical activity guidelines should target reducing and interrupting sedentary time to reduce risk for death
#Sedentary Behavior and Body #Weight and Composition in Adults: A Systematic Review and Meta-analysis of Prospective Studies
https://link.springer.com/article/10.1007/s40279-017-0828-6

The aim of this study was to conduct a systematic review and meta-analysis of prospective cohorts and randomized controlled studies to determine the association between sedentary behavior and body weight and obesity in adults There were no significant associations between sedentary behavior and any measure of body weight or obesity, with the exception of waist circumference. For the latter outcome, over a 5-year follow-up period, each 1 h per day increase—from baseline to follow-up—in sedentary behavior was associated with a 0.02 mm [95% confidence interval (CI) 0.01–0.04; p = 0.001) increase in waist circumference. The odds ratio of becoming overweight or obese was 1.33 (95% CI 1.11–1.60; p = 0.001) in the highest compared with lowest categories of sedentary behavior.

Conclusions

Meta-analysis of data from prospective cohort studies showed small, inconsistent and non-significant associations between sedentary behavior and body weight
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Trends in #Sedentary Behavior Among the US Population, 2001-2016

https://jamanetwork.com/journals/jama/article-abstract/2731178

Prolonged sitting, particularly watching television or videos, has been associated with increased risk of multiple diseases and mortality.

The estimated prevalence of sitting watching television or videos for 2 h/d or more was high among all ages (children, 62% 95% CI, 57% to 67%; adolescents, 59% 95% CI, 54% to 65%; adults, 65% 95% CI, 61% to 69%; adults aged 20-64 years, 62% 95% CI, 58% to 66%; and ≥65 years, 84% 95% CI, 81% to 88% in the 2015-2016 cycle)..

..From 2007 to 2016, total hours per day of sitting time increased among adolescents (7.0 95% CI, 6.7 to 7.4 to 8.2 95% CI, 7.9 to 8.4, difference, 1.1 95% CI, 0.7 to 1.5) and adults (5.5 95% CI, 5.2 to 5.7 to 6.4 95% CI, 6.2 to 6.6; difference, 1.0 95% CI, 0.7 to 1.3; P for trend <.001 for both)..

Conclusions and Relevance In this nationally representative survey of the US population from 2001 through 2016, the estimated prevalence of sitting watching television or videos for at least 2 hours per day generally remained high and stable. The estimated prevalence of computer use during leisure-time increased among all age groups, and the estimated total sitting time increased among adolescents and adults.
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#Energy expenditure differences across lying, sitting, and standing positions in young healthy adults

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217029

The time spent in #sedentary behaviour represents an important public health burden. To reduce sedentary time in the general population, the simplest, most effective, and most accessible method is to decrease lying and sitting time.

We aimed to compare differences on #energy expenditure (EE) across lying, sitting, and standing positions; and to analyse the associations between the change on EE of changing from one position to another and anthropometric and body composition parameters in young healthy adults.

Our findings support the fact that increasing the time spent standing could be a simple strategy to slightly increase EE. Therefore, our results have important clinical implications including a better monitoring, characterizing, and promoting countermeasures to sedentariness through low-level physical activities
#Depressive symptoms and objectively measured physical activity and #sedentary behaviour throughout adolescence: a prospective cohort study

..Higher depression scores at 18 years were associated with a 60 min/day increase in sedentary behaviour at 12 years (incidence rate ratio [IRR] 1·111 [95% CI 1·051–1·176]), 14 years (1·080 [1·012–1·152]), and 16 years of age (1·107 [1·015–1·208]). Depression scores at 18 years were lower for every additional 60 min/day of light activity at 12 years (0·904 [0·850–0·961]), 14 years (0·922 [0·857–0·992]), and 16 years of age (0·889 [0·809–0·974]). Group-based trajectory modelling across 12–16 years of age identified three latent subgroups of sedentary behaviour and activity levels.

Depression scores were higher in those with persistently high (IRR 1·282 [95% CI 1·061–1·548]) and persistently average (1·249 [1·078–1·446]) sedentary behaviour compared with those with persistently low sedentary behaviour, and were lower in those with persistently high levels of light activity (0·804 [0·652–0·990]) compared with those with persistently low levels of light activity. Moderate-to-vigorous physical activity (per 15 min/day increase) at age 12 years (0·910 [0·857–0·966]) and total physical activity (per 100 CPM increase) at ages 12 years (0·941 [0·910–0·972]) and 14 years (0·965 [0·932–0·999]), were negatively associated with depressive symptoms.

Interpretation
Sedentary behaviour displaces light activity throughout adolescence, and is associated with a greater risk of depressive symptoms at 18 years of age. Increasing light activity and decreasing sedentary behaviour during adolescence could be an important target for public health interventions aimed at reducing the prevalence of depression.

https://bit.ly/2tVPMda
Inadequate #Physical Activity and #Sedentary Behavior Are Independent Predictors of Nonalcoholic Fatty #Liver Disease
https://2medical.news/2020/10/30/inadequate-physical-activity-and-ssedentary-behavior-are-independent-predictors-of-nonalcoholic-fatty-liver-disease/

In general, physical activity (PA) and nonalcoholic fatty liver disease (NAFLD) have an inverse association. However, studies assessing the impact of the widely accepted Physical Activity Guidelines for Americans (PA Guidelines) on NAFLD are lacking. We performed a serial, cross‐sectional analysis among adults by using the 2007‐2016 US National Health and Nutrition Examination Survey. NAFLD and advanced fibrosis were defined by using various noninvasive panels. …
Cognitive impairment and #sedentary behavior predict health-related attrition in a prospective longitudinal #Parkinson’s disease study
https://2medical.news/2020/11/21/cognitive-impairment-and-sedentary-behavior-predict-health-related-attrition-in-a-prospective-longitudinal-parkinsons-disease-study/

In Parkinson’s disease (PD), the high burden of motor and non-motor symptoms, such as cognitive impairment or falls, is associated with rapid disease progression and mortality. This is often reflected by an increased drop-out rate of PD patients in longitudinal studies. Active physical behavior can impact the disease course beneficially and has an overall positive effect on health. Contrarily, sedentary behavior is associated with cognitive …
World Health Organization 2020 guidelines on physical #activity and #sedentary behaviour
https://2medical.news/2020/12/03/world-health-organization-2020-guidelines-on-physical-activity-and-sedentary-behaviour/

..The new guidelines address children, adolescents, adults, older adults and include new specific recommendations for pregnant and postpartum women and people living with chronic conditions or disability. All adults should undertake 150–300 min of moderate-intensity, or 75–150 min of vigorous-intensity physical activity, or some equivalent combination of moderate-intensity and vigorous-intensity aerobic physical activity, per week. Among children and adolescents, an average of 60 min/day of moderate-to-vigorous intensity aerobic …
Association of #Sedentary Time and Incident Heart #Failure Hospitalization in Postmenopausal Women
https://2medical.news/2020/12/05/association-of-sedentary-time-and-incident-heart-failure-hospitalization-in-postmenopausal-women/

Background: The 2018 US Physical Activity Guidelines recommend reducing sedentary behavior (SB) for cardiovascular health. SB’s role in heart failure (HF) is unclear. Methods: We studied 80 982 women in the Women’s Health Initiative Observational Study, aged 50 to 79 years, who were without known HF and reported ability to walk ≥1 block unassisted at baseline. Mean follow-up was 9 years for physician-adjudicated incident HF …
Longitudinal Associations of Midlife Accelerometer Determined #Sedentary Behavior and Physical Activity With #Cognitive Function: The CARDIA Study
https://2medical.news/2021/01/26/longitudinal-associations-of-midlife-accelerometer-determined-sedentary-behavior-and-physical-activity-with-cognitive-function-the-cardia-study/

To determine if accelerometer measured sedentary behavior (SED), light‐intensity physical activity (LPA), and moderate‐to‐vigorous–intensity physical activity (MVPA) in midlife is prospectively associated with cognitive function. Participants were 1970 adults enrolled in the CARDIA (Coronary Artery Risk Development in Young Adults) study who wore an accelerometer in 2005 to 2006 (ages 38–50 years) and had cognitive function assessments completed 5 and/or 10 years later. SED, LPA, …
#Pain and fatigue are longitudinally and bi-directionally associated with more #sedentary time and less standing time in #rheumatoid arthritis
https://2medical.news/2021/02/19/pain-and-fatigue-are-longitudinally-and-bi-directionally-associated-with-more-sedentary-time-and-less-standing-time-in-rheumatoid-arthritis/

The aims of this study were to examine the longitudinal and bi-directional associations of pain and fatigue with sedentary, standing and stepping time in RA. Methods People living with RA undertook identical assessments at baseline (T1, n = 104) and 6-month follow-up (T2, n = 54). Participants completed physical measures (e.g. height, weight, BMI) and routine clinical assessments to characterize RA disease activity (DAS-28). Participants also completed questionnaires to …