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Association of Radioactive #Iodine Treatment With Cancer Mortality in Patients With #Hyperthyroidism
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2737319
Radioactive iodine (RAI) has been used extensively to treat hyperthyroidism since the 1940s. Although widely considered a safe and effective therapy, RAI has been associated with elevated risks of total and site-specific cancer death among patients with hypothyroidism.
Mean total administered activity of sodium iodide I 131 was 375 MBq for patients with Graves disease and 653 MBq for patients with toxic nodular goiter. Mean organ or tissue dose estimates ranged from 20 to 99 mGy (colon or rectum, ovary, uterus, prostate, bladder, and brain/central nervous system), to 100 to 400 mGy (pancreas, kidney, liver, stomach, female breast, lung, oral mucosa, and marrow), to 1.6 Gy (esophagus), and to 130 Gy (thyroid gland)...
Conclusions and Relevance
In RAI-treated patients with hyperthyroidism, greater organ-absorbed doses appeared to be modestly positively associated with risk of death from solid cancer, including breast cancer. Additional studies are needed of the risks and advantages of all major treatment options available to patients with hyperthyroidism.
Association of Radioactive #Iodine Treatment With Cancer Mortality in Patients With #Hyperthyroidism
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2737319
Radioactive iodine (RAI) has been used extensively to treat hyperthyroidism since the 1940s. Although widely considered a safe and effective therapy, RAI has been associated with elevated risks of total and site-specific cancer death among patients with hypothyroidism.
Mean total administered activity of sodium iodide I 131 was 375 MBq for patients with Graves disease and 653 MBq for patients with toxic nodular goiter. Mean organ or tissue dose estimates ranged from 20 to 99 mGy (colon or rectum, ovary, uterus, prostate, bladder, and brain/central nervous system), to 100 to 400 mGy (pancreas, kidney, liver, stomach, female breast, lung, oral mucosa, and marrow), to 1.6 Gy (esophagus), and to 130 Gy (thyroid gland)...
Conclusions and Relevance
In RAI-treated patients with hyperthyroidism, greater organ-absorbed doses appeared to be modestly positively associated with risk of death from solid cancer, including breast cancer. Additional studies are needed of the risks and advantages of all major treatment options available to patients with hyperthyroidism.
Jamanetwork
Association of Radioactive Iodine Treatment Dose With Cancer Mortality in Patients With Hyperthyroidism
This cohort study evaluates the level of ionizing radiation exposure and risk of cancer death from a common treatment for hyperthyroidism in a large and longest-running cohort of patients with hyperthyroidism.
Serum #iodine and #breast cancer risk: A prospective nested case-control study stratified for selenium levels
https://2medical.news/2020/06/03/serum-iodine-and-breast-cancer-risk-a-prospective-nested-case-control-study-stratified-for-selenium-levels/
Iodine has been suggested to protect against breast cancer, but there are no epidemiological studies on individual risk. An interesting finding is that in areas where the exposure to both selenium and iodine are high (e.g. Japan), the risk of breast cancer is lower than in areas where selenium is high and iodine low (e.g. USA), or in areas where both are low (e.g. Northern …
https://2medical.news/2020/06/03/serum-iodine-and-breast-cancer-risk-a-prospective-nested-case-control-study-stratified-for-selenium-levels/
Iodine has been suggested to protect against breast cancer, but there are no epidemiological studies on individual risk. An interesting finding is that in areas where the exposure to both selenium and iodine are high (e.g. Japan), the risk of breast cancer is lower than in areas where selenium is high and iodine low (e.g. USA), or in areas where both are low (e.g. Northern …