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Aldo Lorenzetti M.D, Internal Medicine & Hepatology, Milano - SIMEDET Delegate
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Calculated indices of volatile organic compounds (VOCs) in exhalation for #lung #cancer screening and early detection
https://2medical.news/2021/02/17/calculated-indices-of-volatile-organic-compounds-vocs-in-exhalation-for-lung-cancer-screening-and-early-detection/

Breath analysis is a promising noninvasive technique that offers a wide range of opportunities to facilitate early diagnosis of lung cancer (LC). Method Exhaled breath samples of 352 subjects including 160 with lung cancer (LC), 70 with benign pulmonary nodule (BPN) and 122 healthy controls (HC) were analyzed through thermal desorption coupled with gas chromatography-mass spectrometry (TD-GC–MS) to obtain the metabolic information from volatile organic …
American Society of Hematology 2021 guidelines for management of venous #thromboembolism: prevention and treatment in patients with #cancer
https://2medical.news/2021/03/05/american-society-of-hematology-2021-guidelines-for-management-of-venous-thromboembolism-prevention-and-treatment-in-patients-with-cancer/

Venous thromboembolism (VTE) is a common complication among patients with cancer. Patients with cancer and VTE are at a markedly increased risk for morbidity and mortality. Objective: These evidence-based guidelines of the American Society of Hematology (ASH) are intended to support patients, clinicians, and other health care professionals in their decisions about the prevention and treatment of VTE in patients with cancer. Methods: ASH formed …
Broadened Eligibility for #Lung #Cancer Screening Challenges and Uncertainty for Implementation and Equity
https://2medical.news/2021/03/10/broadened-eligibility-for-lung-cancer-screening-challenges-and-uncertainty-for-implementation-and-equity/

In 2013, the US Preventive Services Task Force (USPSTF) recommended annual lung cancer screening with low-dose computed tomography (CT) in US adults aged 55 to 80 years who currently smoke or formerly smoked with a 30 pack-year history, and for those who formerly smoked, quitting within the past 15 years (grade “B” recommendation).1 In this issue of JAMA, the USPSTF updates this recommendation, proposing 2 …
ACG Clinical Guidelines: #Colorectal #Cancer Screening 2021
https://2medical.news/2021/03/12/acg-clinical-guidelines-colorectal-cancer-screening-2021/

1. We recommend CRC screening in average-risk individuals between ages 50 and 75 years to reduce incidence of advanced adenoma, CRC, and mortality from CRC. Strong recommendation; moderate-quality evidence 2. We suggest CRC screening in average-risk individuals between ages 45 and 49 years to reduce incidence of advanced adenoma, CRC, and mortality from CRC. Conditional recommendation; very low-quality evidence 3. We suggest that a decision …
Effectiveness of Electroacupuncture or Auricular #Acupuncture vs Usual Care for Chronic Musculoskeletal Pain Among #Cancer Survivors The PEACE Randomized Clinical Trial
https://2medical.news/2021/03/20/effectiveness-of-electroacupuncture-or-auricular-acupuncture-vs-usual-care-for-chronic-musculoskeletal-pain-among-cancer-survivors-the-peace-randomized-clinical-trial/

The opioid crisis creates challenges for cancer pain management. Acupuncture confers clinical benefits for chronic nonmalignant pain, but its effectiveness in cancer survivors remains uncertain. Objective To determine the effectiveness of electroacupuncture or auricular acupuncture for chronic musculoskeletal pain in cancer survivors. Design, Setting, and Participants The Personalized Electroacupuncture vs Auricular Acupuncture Comparativeness Effectiveness (PEACE) trial is a randomized clinical trial that was conducted from …
Therapeutic Repurposing of #Biguanides in #Cancer
https://2medical.news/2021/04/21/therapeutic-repurposing-of-biguanides-in-cancer/

Biguanides exert antitumor activities through various biochemical mechanisms involving mitochondrial complex I, AMP-activated protein kinase (AMPK), mammalian target of rapamycin (mTOR), and/or mitochondrial glycerophosphate dehydrogenase (mGPD). Biguanides selectively target subpopulations of cancer cells addicted to oxidative phosphorylation (OXPHOS). Metabolic adaptations triggered by biguanide exposure could be potential targets to improve the antitumor efficacy of biguanides. Biguanides modulate antitumor immunity by targeting immune cells in the …