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Aldo Lorenzetti M.D, Internal Medicine & Hepatology, Milano - SIMEDET Delegate
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Potential effect modifiers of the association between physical #activity patterns and #joint symptoms in middle aged women
http://onlinelibrary.wiley.com/doi/10.1002/acr.23430/abstract

To examine whether body mass index (BMI), menopausal status and hormone therapy (HT) use modify the association between physical activity (PA) patterns throughout middle age and incidence and prevalence of joint symptoms in later middle age in women

The groups representing ‘fluctuating’ (odds ratio [OR]=1.34, 99% confidence interval [CI]=1.04-1.72) and ‘none-or-low’ physical activity (OR=1.60, CI =1.08-2.35) had higher odds of incident joint symptoms than those ‘meeting guidelines-at-all-times’. Stratification by BMI showed that this association was statistically significant in the obese group only. No evidence was found for effect modification by menopausal status or HT use. The findings were similar for prevalent joint symptoms.

Conclusions
Maintaining at least low levels of physical activity throughout middle age was associated with lower prevalence and incidence of joint symptoms in later life. This apparent protective effect of physical activity on joint symptoms was stronger in obese women than in under or normal weight women, and not related to menopause and HT status