Epidemiology of #Seasonal Coronaviruses: Establishing the Context for the Emergence of #Coronavirus Disease 2019
https://2medical.news/2020/05/07/epidemiology-of-seasonal-coronaviruses-establishing-the-context-for-the-emergence-of-coronavirus-disease-2019/
Public health preparedness for coronavirus (CoV) disease 2019 (COVID-19) is challenging in the absence of setting-specific epidemiological data. Here we describe the epidemiology of seasonal CoVs (sCoVs) and other cocirculating viruses in the West of Scotland, United Kingdom. We analyzed routine diagnostic data for >70 000 episodes of respiratory illness tested molecularly for multiple respiratory viruses between 2005 and 2017. Statistical associations with patient age …
https://2medical.news/2020/05/07/epidemiology-of-seasonal-coronaviruses-establishing-the-context-for-the-emergence-of-coronavirus-disease-2019/
Public health preparedness for coronavirus (CoV) disease 2019 (COVID-19) is challenging in the absence of setting-specific epidemiological data. Here we describe the epidemiology of seasonal CoVs (sCoVs) and other cocirculating viruses in the West of Scotland, United Kingdom. We analyzed routine diagnostic data for >70 000 episodes of respiratory illness tested molecularly for multiple respiratory viruses between 2005 and 2017. Statistical associations with patient age …
#Delirium In Severe Acute Respiratory Syndrome- #Coronavirus -2 Infection: A Point Of View
https://2medical.news/2020/11/07/delirium-in-severe-acute-respiratory-syndrome-coronavirus-2-infection-a-point-of-view/
Coronavirus disease 2019 was for the first time reported in December 2019 in China, and has since spread throughout the world as a pandemic. In this point of view, we aim to discuss the occurrence of central nervous system symptomatology, and delirium, in patients suffering coronavirus disease 2019. To date, most of the research done around this infectious disease caused by severe acute respiratory syndrome …
https://2medical.news/2020/11/07/delirium-in-severe-acute-respiratory-syndrome-coronavirus-2-infection-a-point-of-view/
Coronavirus disease 2019 was for the first time reported in December 2019 in China, and has since spread throughout the world as a pandemic. In this point of view, we aim to discuss the occurrence of central nervous system symptomatology, and delirium, in patients suffering coronavirus disease 2019. To date, most of the research done around this infectious disease caused by severe acute respiratory syndrome …
Evidence that #coronavirus superspreading is #fat-tailed
https://2medical.news/2020/11/09/evidence-that-coronavirus-superspreading-is-fat-tailed/
Superspreaders, infected individuals who result in an outsized number of secondary cases, are believed to underlie a significant fraction of total SARS-CoV-2 transmission. Here, we combine empirical observations of SARS-CoV and SARS-CoV-2 transmission and extreme value statistics to show that the distribution of secondary cases is consistent with being fat-tailed, implying that large superspreading events are extremal, yet probable, occurrences. We integrate these results with …
https://2medical.news/2020/11/09/evidence-that-coronavirus-superspreading-is-fat-tailed/
Superspreaders, infected individuals who result in an outsized number of secondary cases, are believed to underlie a significant fraction of total SARS-CoV-2 transmission. Here, we combine empirical observations of SARS-CoV and SARS-CoV-2 transmission and extreme value statistics to show that the distribution of secondary cases is consistent with being fat-tailed, implying that large superspreading events are extremal, yet probable, occurrences. We integrate these results with …
Effectiveness of #Prone Positioning in Nonintubated Intensive Care Unit Patients With Moderate to Severe Acute Respiratory Distress Syndrome by #Coronavirus Disease 2019
https://2medical.news/2020/12/20/effectiveness-of-prone-positioning-in-nonintubated-intensive-care-unit-patients-with-moderate-to-severe-acute-respiratory-distress-syndrome-by-coronavirus-disease-2019/
In the treatment for severe acute respiratory distress syndrome (ARDS) from coronavirus disease 2019 (COVID-19), the World Health Organization (WHO) recommends prone positioning (PP) during mechanical ventilation for periods of 12–16 h/d to potentially improve oxygenation and survival. In this prospective observational study, we evaluated the ability of long PP sessions to improve oxygenation in awake intensive care unit (ICU) patients with moderate or severe …
https://2medical.news/2020/12/20/effectiveness-of-prone-positioning-in-nonintubated-intensive-care-unit-patients-with-moderate-to-severe-acute-respiratory-distress-syndrome-by-coronavirus-disease-2019/
In the treatment for severe acute respiratory distress syndrome (ARDS) from coronavirus disease 2019 (COVID-19), the World Health Organization (WHO) recommends prone positioning (PP) during mechanical ventilation for periods of 12–16 h/d to potentially improve oxygenation and survival. In this prospective observational study, we evaluated the ability of long PP sessions to improve oxygenation in awake intensive care unit (ICU) patients with moderate or severe …
#UV-LED disinfection of #Coronavirus: Wavelength effect
https://2medical.news/2020/12/22/uv-led-disinfection-of-coronavirus-wavelength-effect/
UV light-emitting diodes (UV LEDs) are an emerging technology and a UV source for pathogen inactivation, however low UV-LED wavelengths are costly and have low fluence rate. Our results suggest that the sensitivity of human Coronavirus (HCoV-OC43 used as SARS-CoV-2 surrogate) was wavelength dependent with 267 nm ~ 279 nm > 286 nm > 297 nm. Other viruses showed similar results, suggesting UV LED with …
https://2medical.news/2020/12/22/uv-led-disinfection-of-coronavirus-wavelength-effect/
UV light-emitting diodes (UV LEDs) are an emerging technology and a UV source for pathogen inactivation, however low UV-LED wavelengths are costly and have low fluence rate. Our results suggest that the sensitivity of human Coronavirus (HCoV-OC43 used as SARS-CoV-2 surrogate) was wavelength dependent with 267 nm ~ 279 nm > 286 nm > 297 nm. Other viruses showed similar results, suggesting UV LED with …
The #Coronavirus Is Mutating. What Does That Mean for Us?
https://2medical.news/2020/12/23/the-coronavirus-is-mutating-what-does-that-mean-for-us/
By Apoorva Mandavilli – NYT Just as vaccines begin to offer hope for a path out of the pandemic, officials in Britain this past weekend sounded an urgent alarm about what they called a highly contagious new variant of the coronavirus circulating in England. Citing the rapid spread of the virus through London and surrounding areas, Prime Minister Boris Johnson imposed the country’s most stringent …
https://2medical.news/2020/12/23/the-coronavirus-is-mutating-what-does-that-mean-for-us/
By Apoorva Mandavilli – NYT Just as vaccines begin to offer hope for a path out of the pandemic, officials in Britain this past weekend sounded an urgent alarm about what they called a highly contagious new variant of the coronavirus circulating in England. Citing the rapid spread of the virus through London and surrounding areas, Prime Minister Boris Johnson imposed the country’s most stringent …
Low vitamin #D status is associated with #coronavirus disease 2019 outcomes: A systematic review and meta-analysis
https://2medical.news/2021/01/08/low-vitamin-d-status-is-associated-with-coronavirus-disease-2019-outcomes-a-systematic-review-and-meta-analysis/
Observational studies suggest that the risk and clinical prognosis of coronavirus disease 2019 (COVID-19) are related to low vitamin D status; however, the data are inconsistent.. ..A total of 10 articles with 361, 934 participants were selected for meta-analysis. Overall, the pooled OR in the fixed-effect model showed that vitamin D deficiency or insufficiency was associated with an increased risk of COVID-19 (OR = 1.43, 95% CI …
https://2medical.news/2021/01/08/low-vitamin-d-status-is-associated-with-coronavirus-disease-2019-outcomes-a-systematic-review-and-meta-analysis/
Observational studies suggest that the risk and clinical prognosis of coronavirus disease 2019 (COVID-19) are related to low vitamin D status; however, the data are inconsistent.. ..A total of 10 articles with 361, 934 participants were selected for meta-analysis. Overall, the pooled OR in the fixed-effect model showed that vitamin D deficiency or insufficiency was associated with an increased risk of COVID-19 (OR = 1.43, 95% CI …
Early initiation of prophylactic #anticoagulation for prevention of #coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study
https://2medical.news/2021/02/24/early-initiation-of-prophylactic-anticoagulation-for-prevention-of-coronavirus-disease-2019-mortality-in-patients-admitted-to-hospital-in-the-united-states-cohort-study/
To evaluate whether early initiation of prophylactic anticoagulation compared with no anticoagulation was associated with decreased risk of death among patients admitted to hospital with coronavirus disease 2019 (covid-19) in the United States. Design Observational cohort study. Setting Nationwide cohort of patients receiving care in the Department of Veterans Affairs, a large integrated national healthcare system. Participants All 4297 patients admitted to hospital from 1 …
https://2medical.news/2021/02/24/early-initiation-of-prophylactic-anticoagulation-for-prevention-of-coronavirus-disease-2019-mortality-in-patients-admitted-to-hospital-in-the-united-states-cohort-study/
To evaluate whether early initiation of prophylactic anticoagulation compared with no anticoagulation was associated with decreased risk of death among patients admitted to hospital with coronavirus disease 2019 (covid-19) in the United States. Design Observational cohort study. Setting Nationwide cohort of patients receiving care in the Department of Veterans Affairs, a large integrated national healthcare system. Participants All 4297 patients admitted to hospital from 1 …
#Aspirin Use Is Associated With Decreased Mechanical Ventilation, Intensive Care Unit Admission, and In-Hospital Mortality in Hospitalized Patients With #Coronavirus Disease 2019
https://2medical.news/2021/03/26/aspirin-use-is-associated-with-decreased-mechanical-ventilation-intensive-care-unit-admission-and-in-hospital-mortality-in-hospitalized-patients-with-coronavirus-disease-2019/
Coronavirus disease-2019 (COVID-19) is associated with hypercoagulability and increased thrombotic risk in critically ill patients. To our knowledge, no studies have evaluated whether aspirin use is associated with reduced risk of mechanical ventilation, intensive care unit (ICU) admission, and in-hospital mortality. METHODS: A retrospective, observational cohort study of adult patients admitted with COVID-19 to multiple hospitals in the United States between March 2020 and July …
https://2medical.news/2021/03/26/aspirin-use-is-associated-with-decreased-mechanical-ventilation-intensive-care-unit-admission-and-in-hospital-mortality-in-hospitalized-patients-with-coronavirus-disease-2019/
Coronavirus disease-2019 (COVID-19) is associated with hypercoagulability and increased thrombotic risk in critically ill patients. To our knowledge, no studies have evaluated whether aspirin use is associated with reduced risk of mechanical ventilation, intensive care unit (ICU) admission, and in-hospital mortality. METHODS: A retrospective, observational cohort study of adult patients admitted with COVID-19 to multiple hospitals in the United States between March 2020 and July …
#Coronavirus induces #diabetic macrophage-mediated inflammation via SETDB2
https://2medical.news/2021/09/12/coronavirus-induces-diabetic-macrophage-mediated-inflammation-via-setdb2/
https://2medical.news/2021/09/12/coronavirus-induces-diabetic-macrophage-mediated-inflammation-via-setdb2/
2Medical.News
#Coronavirus induces #diabetic macrophage-mediated inflammation via SETDB2
COVID-19 induces a robust, extended inflammatory “cytokine storm” that contributes to an increased morbidity and mortality, particularly in patients with type 2 diabetes (T2D). Macrophages are a ke…