Domestic #Travel During #COVID-19
https://2medical.news/2020/12/06/domestic-travel-during-covid-19/
Before You Consider Traveling Travel can increase your chance of spreading and getting COVID-19. Postponing travel and staying home is the best way to protect yourself and others from COVID-19. If you are considering traveling, here are some important questions to ask yourself and your loved ones beforehand. These questions can help you decide what is best for you and your family. Are you, someone …
https://2medical.news/2020/12/06/domestic-travel-during-covid-19/
Before You Consider Traveling Travel can increase your chance of spreading and getting COVID-19. Postponing travel and staying home is the best way to protect yourself and others from COVID-19. If you are considering traveling, here are some important questions to ask yourself and your loved ones beforehand. These questions can help you decide what is best for you and your family. Are you, someone …
#Menopause Transition and #Cardiovascular Disease Risk: Implications for Timing of Early Prevention: A Scientific Statement From the American Heart Association
https://2medical.news/2020/12/06/menopause-transition-and-cardiovascular-disease-risk-implications-for-timing-of-early-prevention-a-scientific-statement-from-the-american-heart-association/
Cardiovascular disease (CVD) is the leading cause of death in women, who have a notable increase in the risk for this disease after menopause and typically develop coronary heart disease several years later than men. This observation led to the hypothesis that the menopause transition (MT) contributes to the increase in coronary heart disease risk. Over the past 20 years, longitudinal studies of women traversing …
https://2medical.news/2020/12/06/menopause-transition-and-cardiovascular-disease-risk-implications-for-timing-of-early-prevention-a-scientific-statement-from-the-american-heart-association/
Cardiovascular disease (CVD) is the leading cause of death in women, who have a notable increase in the risk for this disease after menopause and typically develop coronary heart disease several years later than men. This observation led to the hypothesis that the menopause transition (MT) contributes to the increase in coronary heart disease risk. Over the past 20 years, longitudinal studies of women traversing …
Managing #Asthma in Adolescents and Adults 2020 Asthma Guideline Update From the National Asthma Education and Prevention Program
https://2medical.news/2020/12/07/managing-asthma-in-adolescents-and-adults-2020-asthma-guideline-update-from-the-national-asthma-education-and-prevention-program/
Asthma is a major public health problem worldwide and is associated with excess morbidity, mortality, and economic costs associated with lost productivity. The National Asthma Education and Prevention Program has released the 2020 Asthma Guideline Update with updated evidence-based recommendations for treatment of patients with asthma.. ..From 20 572 identified references, 475 were included in the 6 systematic reviews to form the evidence basis for these …
https://2medical.news/2020/12/07/managing-asthma-in-adolescents-and-adults-2020-asthma-guideline-update-from-the-national-asthma-education-and-prevention-program/
Asthma is a major public health problem worldwide and is associated with excess morbidity, mortality, and economic costs associated with lost productivity. The National Asthma Education and Prevention Program has released the 2020 Asthma Guideline Update with updated evidence-based recommendations for treatment of patients with asthma.. ..From 20 572 identified references, 475 were included in the 6 systematic reviews to form the evidence basis for these …
#Older age does not influence the success of #weight loss through the implementation of lifestyle modification
https://2medical.news/2020/12/07/older-age-does-not-influence-the-success-of-weight-loss-through-the-implementation-of-lifestyle-modification/
Age is sometimes a barrier for acceptance of patients into a hospital‐based obesity service. Our aim was to explore the effect of age on the ability to lose weight through lifestyle interventions, implemented within a hospital‐based obesity service.. Primary outcome measures were percentage weight loss (%WL) and percentage reduction in body mass index (%rBMI) following implemented lifestyle interventions. Data were stratified according to patient age …
https://2medical.news/2020/12/07/older-age-does-not-influence-the-success-of-weight-loss-through-the-implementation-of-lifestyle-modification/
Age is sometimes a barrier for acceptance of patients into a hospital‐based obesity service. Our aim was to explore the effect of age on the ability to lose weight through lifestyle interventions, implemented within a hospital‐based obesity service.. Primary outcome measures were percentage weight loss (%WL) and percentage reduction in body mass index (%rBMI) following implemented lifestyle interventions. Data were stratified according to patient age …
Lifetime perspective on #alcohol and #brain health
https://2medical.news/2020/12/08/lifetime-perspective-on-alcohol-and-brain-health/
Harm prevention policies must take the long view The maintenance of brain health is central to health and wellbeing across the lifespan.1 Evidence suggests three periods of dynamic brain changes that may be particularly sensitive to the neurotoxic effects of alcohol: gestation (from conception to birth), later adolescence (15-19 years), and older adulthood (over 65 years). Highly prevalent patterns of alcohol use may cause harm …
https://2medical.news/2020/12/08/lifetime-perspective-on-alcohol-and-brain-health/
Harm prevention policies must take the long view The maintenance of brain health is central to health and wellbeing across the lifespan.1 Evidence suggests three periods of dynamic brain changes that may be particularly sensitive to the neurotoxic effects of alcohol: gestation (from conception to birth), later adolescence (15-19 years), and older adulthood (over 65 years). Highly prevalent patterns of alcohol use may cause harm …
Blood #Pressure Changes in 1610 Subjects With and Without Antihypertensive Medication During Long‐Term #Fasting
https://2medical.news/2020/12/08/blood-pressure-changes-in-1610-subjects-with-and-without-antihypertensive-medication-during-long%E2%80%90term-fasting/
We investigated daily blood pressure (BP) changes during fasting periods ranging from 4 to 41 (10.0±3.8) days in a cohort of 1610 subjects, including 920 normotensive, 313 hypertensive nonmedicated, and 377 hypertensive medicated individuals. Methods and Results Subjects underwent a multidisciplinary fasting program with a daily intake of ≈250 kcal. Weight and stress scores decreased during fasting, and the well‐being index increased, documenting a good …
https://2medical.news/2020/12/08/blood-pressure-changes-in-1610-subjects-with-and-without-antihypertensive-medication-during-long%E2%80%90term-fasting/
We investigated daily blood pressure (BP) changes during fasting periods ranging from 4 to 41 (10.0±3.8) days in a cohort of 1610 subjects, including 920 normotensive, 313 hypertensive nonmedicated, and 377 hypertensive medicated individuals. Methods and Results Subjects underwent a multidisciplinary fasting program with a daily intake of ≈250 kcal. Weight and stress scores decreased during fasting, and the well‐being index increased, documenting a good …
Older Adults and the Mental Health Effects of #COVID-19
https://2medical.news/2020/12/09/older-adults-and-the-mental-health-effects-of-covid-19/
As the coronavirus disease 2019 (COVID-19) began to spread in the US in early 2020, older adults experienced disproportionately greater adverse effects from the pandemic including more severe complications, higher mortality, concerns about disruptions to their daily routines and access to care, difficulty in adapting to technologies like telemedicine, and concerns that isolation would exacerbate existing mental health conditions. Older adults tend to have lower …
https://2medical.news/2020/12/09/older-adults-and-the-mental-health-effects-of-covid-19/
As the coronavirus disease 2019 (COVID-19) began to spread in the US in early 2020, older adults experienced disproportionately greater adverse effects from the pandemic including more severe complications, higher mortality, concerns about disruptions to their daily routines and access to care, difficulty in adapting to technologies like telemedicine, and concerns that isolation would exacerbate existing mental health conditions. Older adults tend to have lower …
#Cognitive decline in older adults with #epilepsy: The Cardiovascular Health Study
https://2medical.news/2020/12/09/cognitive-decline-in-older-adults-with-epilepsy-the-cardiovascular-health-study/
Cognitive decline is a major concern for older adults with epilepsy. Whether and how much faster older adults with epilepsy experience cognitive decline beyond expected age‐related cognitive change remain unclear. We sought to estimate and compare rates of cognitive decline in older adults with and without epilepsy.. ..The rate of decline in 3MS was significantly faster in prevalent epilepsy (P < .001) and after incident …
https://2medical.news/2020/12/09/cognitive-decline-in-older-adults-with-epilepsy-the-cardiovascular-health-study/
Cognitive decline is a major concern for older adults with epilepsy. Whether and how much faster older adults with epilepsy experience cognitive decline beyond expected age‐related cognitive change remain unclear. We sought to estimate and compare rates of cognitive decline in older adults with and without epilepsy.. ..The rate of decline in 3MS was significantly faster in prevalent epilepsy (P < .001) and after incident …
Incidence rates of severe #cutaneous adverse reactions due to anti #seizure medication: A nationwide study using health claims data in Korea
https://2medical.news/2020/12/10/incidence-rates-of-severe-cutaneous-adverse-reactions-due-to-anti-seizure-medication-a-nationwide-study-using-health-claims-data-in-korea/
Antiseizure medications (ASMs) can rarely result in severe, sometimes fatal, cutaneous adverse reactions. To date, few studies have reported on the incidence rates (IRs) of severe cutaneous adverse reactions (SCARs) due to ASM use. This study aimed to determine the IRs of SCAR resulting from the use of seven commonly prescribed ASMs, carbamazepine (CBZ), phenytoin (PHT), oxcarbazepine (OXC), lamotrigine (LMT), zonisamide (ZNS), levetiracetam (LVT), and …
https://2medical.news/2020/12/10/incidence-rates-of-severe-cutaneous-adverse-reactions-due-to-anti-seizure-medication-a-nationwide-study-using-health-claims-data-in-korea/
Antiseizure medications (ASMs) can rarely result in severe, sometimes fatal, cutaneous adverse reactions. To date, few studies have reported on the incidence rates (IRs) of severe cutaneous adverse reactions (SCARs) due to ASM use. This study aimed to determine the IRs of SCAR resulting from the use of seven commonly prescribed ASMs, carbamazepine (CBZ), phenytoin (PHT), oxcarbazepine (OXC), lamotrigine (LMT), zonisamide (ZNS), levetiracetam (LVT), and …
Post-lockdown SARS- #CoV-2 nucleic acid screening in nearly ten million residents of Wuhan, China
https://2medical.news/2020/12/10/post-lockdown-sars-cov-2-nucleic-acid-screening-in-nearly-ten-million-residents-of-wuhan-china/
Stringent COVID-19 control measures were imposed in Wuhan between January 23 and April 8, 2020. Estimates of the prevalence of infection following the release of restrictions could inform post-lockdown pandemic management. Here, we describe a city-wide SARS-CoV-2 nucleic acid screening programme between May 14 and June 1, 2020 in Wuhan. All city residents aged six years or older were eligible and 9,899,828 (92.9%) participated. No …
https://2medical.news/2020/12/10/post-lockdown-sars-cov-2-nucleic-acid-screening-in-nearly-ten-million-residents-of-wuhan-china/
Stringent COVID-19 control measures were imposed in Wuhan between January 23 and April 8, 2020. Estimates of the prevalence of infection following the release of restrictions could inform post-lockdown pandemic management. Here, we describe a city-wide SARS-CoV-2 nucleic acid screening programme between May 14 and June 1, 2020 in Wuhan. All city residents aged six years or older were eligible and 9,899,828 (92.9%) participated. No …
Assessment of Physician #Sleep and Wellness, #Burnout, and Clinically Significant Medical Errors
https://2medical.news/2020/12/11/assessment-of-physician-sleep-and-wellness-burnout-and-clinically-significant-medical-errors/
Sleep-related impairment in physicians is an occupational hazard associated with long and sometimes unpredictable work hours and may contribute to burnout and self-reported clinically significant medical error.. ..Of all physicians invited to participate in the survey, 7700 of 19 384 attending physicians (40%) and 3695 of 7257 house staff physicians (51%) completed sleep-related impairment items, including 5279 women (46%), 5187 men (46%), and 929 (8%) who …
https://2medical.news/2020/12/11/assessment-of-physician-sleep-and-wellness-burnout-and-clinically-significant-medical-errors/
Sleep-related impairment in physicians is an occupational hazard associated with long and sometimes unpredictable work hours and may contribute to burnout and self-reported clinically significant medical error.. ..Of all physicians invited to participate in the survey, 7700 of 19 384 attending physicians (40%) and 3695 of 7257 house staff physicians (51%) completed sleep-related impairment items, including 5279 women (46%), 5187 men (46%), and 929 (8%) who …
Vitamin #D metabolites and the gut #microbiome in older men
https://2medical.news/2020/12/11/vitamin-d-metabolites-and-the-gut-microbiome-in-older-men/
The vitamin D receptor is highly expressed in the gastrointestinal tract where it transacts gene expression. With current limited understanding of the interactions between the gut microbiome and vitamin D, we conduct a cross-sectional analysis of 567 older men quantifying serum vitamin D metabolites using LC-MSMS and defining stool sub-Operational Taxonomic Units from16S ribosomal RNA gene sequencing data. Faith’s Phylogenetic Diversity and non-redundant covariate analyses …
https://2medical.news/2020/12/11/vitamin-d-metabolites-and-the-gut-microbiome-in-older-men/
The vitamin D receptor is highly expressed in the gastrointestinal tract where it transacts gene expression. With current limited understanding of the interactions between the gut microbiome and vitamin D, we conduct a cross-sectional analysis of 567 older men quantifying serum vitamin D metabolites using LC-MSMS and defining stool sub-Operational Taxonomic Units from16S ribosomal RNA gene sequencing data. Faith’s Phylogenetic Diversity and non-redundant covariate analyses …
#Cooking as a Health Behavior: Examining the Role of Cooking Classes in a #Weight Loss Intervention
https://2medical.news/2020/12/12/cooking-as-a-health-behavior-examining-the-role-of-cooking-classes-in-a-weight-loss-intervention/
Americans are cooking fewer meals at home and eating more convenience foods prepared elsewhere. Cooking at home is associated with higher quality diets, while a reduction in cooking may be associated with increases in obesity and risk factors for chronic disease. The aims of this study were to examine cooking as an intervention for weight control in overweight and obese adults, and whether such an …
https://2medical.news/2020/12/12/cooking-as-a-health-behavior-examining-the-role-of-cooking-classes-in-a-weight-loss-intervention/
Americans are cooking fewer meals at home and eating more convenience foods prepared elsewhere. Cooking at home is associated with higher quality diets, while a reduction in cooking may be associated with increases in obesity and risk factors for chronic disease. The aims of this study were to examine cooking as an intervention for weight control in overweight and obese adults, and whether such an …
#EPA and #DHA differentially modulate monocyte #inflammatory response in subjects with chronic inflammation in part via plasma specialized pro-resolving lipid mediators: A randomized, double-blind, crossover study
https://2medical.news/2020/12/12/epa-and-dha-differentially-modulate-monocyte-inflammatory-response-in-subjects-with-chronic-inflammation-in-part-via-plasma-specialized-pro-resolving-lipid-mediators-a-randomized-double-blind-cr/
The independent effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on chronic inflammation through their downstream lipid mediators, including the specialized pro-resolving lipid mediators (SPM), remain unstudied. Therefore, we compared the effects of EPA and DHA supplementation on monocyte inflammatory response and plasma polyunsaturated fatty acids (PUFA) SPM lipidome.. After a 4-week lead-in phase (baseline), 9 men and 12 postmenopausal women (50–75 years) with …
https://2medical.news/2020/12/12/epa-and-dha-differentially-modulate-monocyte-inflammatory-response-in-subjects-with-chronic-inflammation-in-part-via-plasma-specialized-pro-resolving-lipid-mediators-a-randomized-double-blind-cr/
The independent effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on chronic inflammation through their downstream lipid mediators, including the specialized pro-resolving lipid mediators (SPM), remain unstudied. Therefore, we compared the effects of EPA and DHA supplementation on monocyte inflammatory response and plasma polyunsaturated fatty acids (PUFA) SPM lipidome.. After a 4-week lead-in phase (baseline), 9 men and 12 postmenopausal women (50–75 years) with …
UK probes whether #COVID-19 vaccine caused #allergic reactions
https://2medical.news/2020/12/13/uk-probes-whether-covid-19-vaccine-caused-allergic-reactions/
LONDON (AP) — Britain’s medical regulator warned Wednesday that people with a history of serious allergic reactions shouldn’t get the COVID-19 vaccine from Pfizer and BioNTech, and investigators looked into whether two reactions on the first day of the U.K.’s vaccination program were linked to the shot. The advice was issued on a “precautionary basis,” and the people who had the reactions had recovered, said …
https://2medical.news/2020/12/13/uk-probes-whether-covid-19-vaccine-caused-allergic-reactions/
LONDON (AP) — Britain’s medical regulator warned Wednesday that people with a history of serious allergic reactions shouldn’t get the COVID-19 vaccine from Pfizer and BioNTech, and investigators looked into whether two reactions on the first day of the U.K.’s vaccination program were linked to the shot. The advice was issued on a “precautionary basis,” and the people who had the reactions had recovered, said …
Effects of #probiotics on gut #microbiota: mechanisms of intestinal immunomodulation and neuromodulation
https://2medical.news/2020/12/13/effects-of-probiotics-on-gut-microbiota-mechanisms-of-intestinal-immunomodulation-and-neuromodulation/
Recent explorations of the human gut microbiota suggest that perturbations of microbial communities may increase predisposition to different disease phenotypes. Dietary nutrients may be converted into metabolites by intestinal microbes that serve as biologically active molecules affecting regulatory functions in the host. Probiotics may restore the composition of the gut microbiome and introduce beneficial functions to gut microbial communities, resulting in amelioration or prevention of …
https://2medical.news/2020/12/13/effects-of-probiotics-on-gut-microbiota-mechanisms-of-intestinal-immunomodulation-and-neuromodulation/
Recent explorations of the human gut microbiota suggest that perturbations of microbial communities may increase predisposition to different disease phenotypes. Dietary nutrients may be converted into metabolites by intestinal microbes that serve as biologically active molecules affecting regulatory functions in the host. Probiotics may restore the composition of the gut microbiome and introduce beneficial functions to gut microbial communities, resulting in amelioration or prevention of …
Human #Health and Ocean #Pollution
https://2medical.news/2020/12/14/human-health-and-ocean-pollution/
..Human Health Findings: Methylmercury and PCBs are the ocean pollutants whose human health effects are best understood. Exposures of infants in utero to these pollutants through maternal consumption of contaminated seafood can damage developing brains, reduce IQ and increase children’s risks for autism, ADHD and learning disorders. Adult exposures to methylmercury increase risks for cardiovascular disease and dementia. Manufactured chemicals – phthalates, bisphenol A, flame …
https://2medical.news/2020/12/14/human-health-and-ocean-pollution/
..Human Health Findings: Methylmercury and PCBs are the ocean pollutants whose human health effects are best understood. Exposures of infants in utero to these pollutants through maternal consumption of contaminated seafood can damage developing brains, reduce IQ and increase children’s risks for autism, ADHD and learning disorders. Adult exposures to methylmercury increase risks for cardiovascular disease and dementia. Manufactured chemicals – phthalates, bisphenol A, flame …
Association between circulating #vascular-related microRNAs and an increase in blood #pressure: a 5-year longitudinal population-based study
https://2medical.news/2020/12/14/association-between-circulating-vascular-related-micrornas-and-an-increase-in-blood-pressure-a-5-year-longitudinal-population-based-study/
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression and play essential roles in the pathogenesis of cardiovascular disease. Previous cross-sectional studies showed that the levels of several circulating miRNA are associated with hypertension, but there are no prospective longitudinal studies using a general population. The aim of this study is to evaluate the impact of circulating vascular-related miRNA (miR-126, miR-221, and miR-222) on …
https://2medical.news/2020/12/14/association-between-circulating-vascular-related-micrornas-and-an-increase-in-blood-pressure-a-5-year-longitudinal-population-based-study/
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression and play essential roles in the pathogenesis of cardiovascular disease. Previous cross-sectional studies showed that the levels of several circulating miRNA are associated with hypertension, but there are no prospective longitudinal studies using a general population. The aim of this study is to evaluate the impact of circulating vascular-related miRNA (miR-126, miR-221, and miR-222) on …
#Blood type #diets lack supporting evidence: a systematic review
https://2medical.news/2020/12/15/blood-type-diets-lack-supporting-evidence-a-systematic-review/
Background: Diets that are based on the ABO blood group system have been promoted over the past decade and claim to improve health and decrease risk of disease. To our knowledge, the evidence to support the effectiveness of blood type diets has not previously been assessed in the scientific literature. Objective: In this current systematic review, published studies that presented data related to blood type …
https://2medical.news/2020/12/15/blood-type-diets-lack-supporting-evidence-a-systematic-review/
Background: Diets that are based on the ABO blood group system have been promoted over the past decade and claim to improve health and decrease risk of disease. To our knowledge, the evidence to support the effectiveness of blood type diets has not previously been assessed in the scientific literature. Objective: In this current systematic review, published studies that presented data related to blood type …
#IgA dominates the early neutralizing antibody response to #SARS-CoV-2
https://2medical.news/2020/12/15/iga-dominates-the-early-neutralizing-antibody-response-to-sars-cov-2/
Abstract Humoral immune responses are typically characterized by primary IgM antibody responses followed by secondary antibody responses associated with immune memory and comprised of of IgG, IgA and IgE. Here we measured acute humoral responses to SARS-CoV-2, including the frequency of antibody-secreting cells and the presence of SARS-CoV-2-specific neutralizing antibodies in the serum, saliva and broncho-alveolar fluid of 159 patients with COVID-19. Early SARS-CoV-2-specific humoral …
https://2medical.news/2020/12/15/iga-dominates-the-early-neutralizing-antibody-response-to-sars-cov-2/
Abstract Humoral immune responses are typically characterized by primary IgM antibody responses followed by secondary antibody responses associated with immune memory and comprised of of IgG, IgA and IgE. Here we measured acute humoral responses to SARS-CoV-2, including the frequency of antibody-secreting cells and the presence of SARS-CoV-2-specific neutralizing antibodies in the serum, saliva and broncho-alveolar fluid of 159 patients with COVID-19. Early SARS-CoV-2-specific humoral …
Changes in Body #Mass Index Are Related to Faster #Cognitive Decline Among African American Older Adults
https://2medical.news/2020/12/16/changes-in-body-mass-index-are-related-to-faster-cognitive-decline-among-african-american-older-adults/
The purpose of this study was to: (1) examine relationships between body mass index (BMI) stability and cognitive decline in older African Americans; and (2) investigate differences in the relationships between women and men.. ..Participants (n = 671; mean age = 73.5 years; standard deviation = 6.2 years) were included in the present analysis if they were dementia free at baseline and completed at least two clinical …
https://2medical.news/2020/12/16/changes-in-body-mass-index-are-related-to-faster-cognitive-decline-among-african-american-older-adults/
The purpose of this study was to: (1) examine relationships between body mass index (BMI) stability and cognitive decline in older African Americans; and (2) investigate differences in the relationships between women and men.. ..Participants (n = 671; mean age = 73.5 years; standard deviation = 6.2 years) were included in the present analysis if they were dementia free at baseline and completed at least two clinical …