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Occupational #radiation exposure and excess additive risk of #cataract incidence in a cohort of US radiologic technologists
..There were 11 345 cataract diagnoses and 5440 of cataract surgery during 832 462 and 888 402 person-years of follow-up, respectively. Cumulative occupational radiation exposure was associated with self-reported cataract, but not with cataract surgery, with EAR/104 person-year Gy=94 (95% CI: 47 to 143, p<0.001) and EAR/104 person-year Gy=13 (95% CI: <0 to 57, p=0.551), respectively. There was marked (p<0.001) variation of EAR by age and by diabetes status, with risk higher among persons ≥75 years and diabetics. There were indications of elevated risk among those with higher UVB radiation (p=0.045), whites (p=0.056) and among those with higher levels of cigarette smoking (p=0.062). Elevated additive risk was observed for estimated occupational radiation eye-lens doses <100 mGy (p=0.004) with no dose–response curvature (p=0.903).
Conclusions The elevated additive risks associated with low-dose radiation, if confirmed elsewhere, have important public health and clinical implications for radiation workers as well as regulatory measures.
https://bit.ly/2QfjNf7
Occupational #radiation exposure and excess additive risk of #cataract incidence in a cohort of US radiologic technologists
..There were 11 345 cataract diagnoses and 5440 of cataract surgery during 832 462 and 888 402 person-years of follow-up, respectively. Cumulative occupational radiation exposure was associated with self-reported cataract, but not with cataract surgery, with EAR/104 person-year Gy=94 (95% CI: 47 to 143, p<0.001) and EAR/104 person-year Gy=13 (95% CI: <0 to 57, p=0.551), respectively. There was marked (p<0.001) variation of EAR by age and by diabetes status, with risk higher among persons ≥75 years and diabetics. There were indications of elevated risk among those with higher UVB radiation (p=0.045), whites (p=0.056) and among those with higher levels of cigarette smoking (p=0.062). Elevated additive risk was observed for estimated occupational radiation eye-lens doses <100 mGy (p=0.004) with no dose–response curvature (p=0.903).
Conclusions The elevated additive risks associated with low-dose radiation, if confirmed elsewhere, have important public health and clinical implications for radiation workers as well as regulatory measures.
https://bit.ly/2QfjNf7
Occupational & Environmental Medicine
Occupational radiation exposure and excess additive risk of cataract incidence in a cohort of US radiologic technologists
Objectives Previous analyses of cataract in radiation-exposed populations have assessed relative risk; radiogenic excess additive risk (EAR), arguably of more public health importance, has not been estimated. Previous analysis of a large prospective cohort…
#Smoking, #Radiation Therapy, and Contralateral #Breast Cancer Risk in Young Women
https://2medical.news/2021/04/02/smoking-radiation-therapy-and-contralateral-breast-cancer-risk-in-young-women/
Evidence is mounting that cigarette smoking contributes to second primary contralateral breast cancer (CBC) risk. Whether radiation therapy (RT) interacts with smoking to modify this risk is unknown. In this multicenter, individually-matched case-control study, we examined the association between RT, smoking, and CBC risk. The study included 1,521 CBC cases and 2,212 controls with unilateral breast cancer, all diagnosed with first invasive breast cancer between …
https://2medical.news/2021/04/02/smoking-radiation-therapy-and-contralateral-breast-cancer-risk-in-young-women/
Evidence is mounting that cigarette smoking contributes to second primary contralateral breast cancer (CBC) risk. Whether radiation therapy (RT) interacts with smoking to modify this risk is unknown. In this multicenter, individually-matched case-control study, we examined the association between RT, smoking, and CBC risk. The study included 1,521 CBC cases and 2,212 controls with unilateral breast cancer, all diagnosed with first invasive breast cancer between …
Low Doses of Ionizing #Radiation as a Treatment for #Alzheimer’s Disease: A Pilot Study
https://2medical.news/2021/05/07/low-doses-of-ionizing-radiation-as-a-treatment-for-alzheimers-disease-a-pilot-study/
https://2medical.news/2021/05/07/low-doses-of-ionizing-radiation-as-a-treatment-for-alzheimers-disease-a-pilot-study/
2Medical.News
Low Doses of Ionizing #Radiation as a Treatment for #Alzheimer’s Disease: A Pilot Study
In 2015, a patient in hospice with Alzheimer’s disease (AD) was treated with ionizing radiation to her brain using repeated CT scans. Improvement in cognition, speech, movement, and appetite was ob…