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Low plasma #adropin concentrations increase risks of #weight gain and metabolic dysregulation in response to a high-sugar diet in male nonhuman primates
http://m.jbc.org/content/early/2019/04/15/jbc.RA119.007528
Mouse studies linking adropin, a peptide hormone encoded by the energy homeostasis associated (ENHO) gene, to biological clocks and to glucose and lipid metabolism suggest a potential therapeutic target for managing diseases of metabolism. However, adropin’s roles in human metabolism are unclear.
ENHO expression is abundant in brain, including ventromedial and lateral hypothalamic nuclei regulating appetite and autonomic function. Lower ENHO expression is present in liver, lung, kidney, ileum, and some endocrine glands. Hepatic ENHO expression associates with genes involved in glucose and lipid metabolism.
During consumption of a high sugar (fructose) diet which induced 10% weight gain, animals with low adropin had larger increases of plasma leptin and more severe hyperglycemia. Declining adropin concentrations were correlated with increases of plasma APOC3 and triglycerides.
In summary, peripheral ENHO expression associates with pathways related to epigenetic and neural pathways, and carbohydrate and lipid metabolism, suggesting co-regulation in nonhuman primates. Low circulating adropin predicts increased weight gain and metabolic dysregulation during consumption of a high-sugar diet.
Low plasma #adropin concentrations increase risks of #weight gain and metabolic dysregulation in response to a high-sugar diet in male nonhuman primates
http://m.jbc.org/content/early/2019/04/15/jbc.RA119.007528
Mouse studies linking adropin, a peptide hormone encoded by the energy homeostasis associated (ENHO) gene, to biological clocks and to glucose and lipid metabolism suggest a potential therapeutic target for managing diseases of metabolism. However, adropin’s roles in human metabolism are unclear.
ENHO expression is abundant in brain, including ventromedial and lateral hypothalamic nuclei regulating appetite and autonomic function. Lower ENHO expression is present in liver, lung, kidney, ileum, and some endocrine glands. Hepatic ENHO expression associates with genes involved in glucose and lipid metabolism.
During consumption of a high sugar (fructose) diet which induced 10% weight gain, animals with low adropin had larger increases of plasma leptin and more severe hyperglycemia. Declining adropin concentrations were correlated with increases of plasma APOC3 and triglycerides.
In summary, peripheral ENHO expression associates with pathways related to epigenetic and neural pathways, and carbohydrate and lipid metabolism, suggesting co-regulation in nonhuman primates. Low circulating adropin predicts increased weight gain and metabolic dysregulation during consumption of a high-sugar diet.