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Association of High Intakes of Vitamins #B6 and #B12 From Food and Supplements With Risk of Hip #Fracture Among Postmenopausal Women in the Nurses’ Health Study

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2733176

..Median (interquartile range) cumulative average intakes of total vitamins B6 and B12 were 3.6 (4.8) mg/d and 12.1 (11.7) μg/d, respectively. Both vitamin B6 (RR, 1.29; 95% CI, 1.04-1.59 for an intake of ≥35 vs <2 mg/d; P = .06 for linear trend) and vitamin B12 (RR, 1.25; 95% CI, 0.98-1.58 for an intake of ≥30 vs <5 μg/d; P = .02 for linear trend) were associated with increased fracture risk. Risk was highest in women with a combined high intake of both vitamins (B6 ≥35 mg/d and B12 ≥20 μg/d), exhibiting an almost 50% increased risk of hip fracture (RR, 1.47; 95% CI, 1.15-1.89) compared with women with a low intake of both vitamins (B6 <2 mg/d and B12 <10 μg/d).

Conclusions and Relevance In this cohort study, a combined high intake of vitamins B6 and B12 was associated with an increased risk of hip fracture. The intakes were far higher than the recommended dietary allowances. These findings add to previous studies suggesting that vitamin supplements should be used cautiously because adverse effects can occur.

Vitamin #B12 is a limiting factor for induced cellular plasticity and #tissue repair

https://2medical.news/2023/11/27/vitamin-b12-is-a-limiting-factor-for-induced-cellular-plasticity-and-tissue-repair/