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#Porphyromonas gingivalis in #Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

http://advances.sciencemag.org/content/5/1/eaau3333

Porphyromonas gingivalis, the keystone pathogen in chronic periodontitis, was identified in the brain of Alzheimer’s disease patients. Toxic proteases from the bacterium called gingipains were also identified in the brain of Alzheimer’s patients, and levels correlated with tau and ubiquitin pathology. Oral P. gingivalis infection in mice resulted in brain colonization and increased production of Aβ1–42, a component of amyloid plaques