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#Cognitive Impact of Cerebral Small #Vessel Disease Changes in Patients With Hypertension
https://www.ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.118.12090
Hypertension is one of the principal risk factors for cerebral small vessel disease progression and cognitive impairment.
Considering the progression of cerebral small vessel disease, the prevalence of incident infarcts was 6.1% and that of incident cerebral microbleeds was 5.5%; progression of periventricular WMH was 22% and that of deep WMH was 48%. Patients with marked progression of periventricular WMH showed a significant decrease in global cognition compared with patients without progression (adjusted mean [SE], −0.519 [0.176] versus 0.057 [0.044], respectively; P value=0.004) and a higher risk of incident mild cognitive impairment (OR, 6.184; 95% CI, 1.506–25.370; P value=0.011).
Therefore, our results indicate that hypertensive patients with progression of periventricular WMH have higher odds of cognitive impairment, even in the early stages of cognitive decline.
#Cognitive Impact of Cerebral Small #Vessel Disease Changes in Patients With Hypertension
https://www.ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.118.12090
Hypertension is one of the principal risk factors for cerebral small vessel disease progression and cognitive impairment.
Considering the progression of cerebral small vessel disease, the prevalence of incident infarcts was 6.1% and that of incident cerebral microbleeds was 5.5%; progression of periventricular WMH was 22% and that of deep WMH was 48%. Patients with marked progression of periventricular WMH showed a significant decrease in global cognition compared with patients without progression (adjusted mean [SE], −0.519 [0.176] versus 0.057 [0.044], respectively; P value=0.004) and a higher risk of incident mild cognitive impairment (OR, 6.184; 95% CI, 1.506–25.370; P value=0.011).
Therefore, our results indicate that hypertensive patients with progression of periventricular WMH have higher odds of cognitive impairment, even in the early stages of cognitive decline.