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Skeletal #Muscles Do Not Undergo Apoptosis During Either #Atrophy or Programmed Cell Death-Revisiting the Myonuclear Domain Hypothesis
https://www.frontiersin.org/articles/10.3389/fphys.2018.01887/full
Muscle memory discovery ends 'use it or lose it' dogma
Skeletal muscles are the largest cells in the body and are one of the few syncytial ones. There is a longstanding belief that a given nucleus controls a defined volume of cytoplasm, so when a muscle grows (hypertrophy) or shrinks (atrophy), the number of myonuclei change accordingly. This phenomenon is known as the “myonuclear domain hypothesis.”
Recently, two independent models, one from rodents and the other from insects, have demonstrated that nuclei are not lost from skeletal muscle fibers when they undergo either atrophy or programmed cell death. These and other data argue against the current interpretation of the myonuclear domain hypothesis and suggest that once a nucleus has been acquired by a muscle fiber it persists.
Skeletal #Muscles Do Not Undergo Apoptosis During Either #Atrophy or Programmed Cell Death-Revisiting the Myonuclear Domain Hypothesis
https://www.frontiersin.org/articles/10.3389/fphys.2018.01887/full
Muscle memory discovery ends 'use it or lose it' dogma
Skeletal muscles are the largest cells in the body and are one of the few syncytial ones. There is a longstanding belief that a given nucleus controls a defined volume of cytoplasm, so when a muscle grows (hypertrophy) or shrinks (atrophy), the number of myonuclei change accordingly. This phenomenon is known as the “myonuclear domain hypothesis.”
Recently, two independent models, one from rodents and the other from insects, have demonstrated that nuclei are not lost from skeletal muscle fibers when they undergo either atrophy or programmed cell death. These and other data argue against the current interpretation of the myonuclear domain hypothesis and suggest that once a nucleus has been acquired by a muscle fiber it persists.
Frontiers
Frontiers | Skeletal Muscles Do Not Undergo Apoptosis During Either Atrophy or Programmed Cell Death-Revisiting the Myonuclear…
Skeletal muscles are the largest cells in the body and are one of the few syncytial ones. There is a longstanding belief that a given nucleus controls a defi...