Effect of #procalcitonin-guided antibiotic treatment on mortality in acute respiratory #infections: a patient level meta-analysis
http://thelancet.com/journals/laninf/article/PIIS1473-3099(17)30592-3/fulltext
.. Mortality at 30 days was significantly lower in procalcitonin-guided patients than in control patients (286 9% deaths in 3336 procalcitonin-guided patients vs 336 10% in 3372 controls; adjusted odds ratio OR 0·83 95% CI 0·70 to 0·99, p=0·037). This mortality benefit was similar across subgroups by setting and type of infection (pinteractions>0·05), although mortality was very low in primary care and in patients with acute bronchitis. Procalcitonin guidance was also associated with a 2·4-day reduction in antibiotic exposure (5·7 vs 8·1 days 95% CI −2·71 to −2·15, p<0·0001) and a reduction in antibiotic-related side-effects (16% vs 22%, adjusted OR 0·68 95% CI 0·57 to 0·82, p<0·0001).
Interpretation
Use of procalcitonin to guide antibiotic treatment in patients with acute respiratory infections reduces antibiotic exposure and side-effects, and improves survival. Widespread implementation of procalcitonin protocols in patients with acute respiratory infections thus has the potential to improve antibiotic management with positive effects on clinical outcomes and on the current threat of increasing antibiotic multiresistance
http://thelancet.com/journals/laninf/article/PIIS1473-3099(17)30592-3/fulltext
.. Mortality at 30 days was significantly lower in procalcitonin-guided patients than in control patients (286 9% deaths in 3336 procalcitonin-guided patients vs 336 10% in 3372 controls; adjusted odds ratio OR 0·83 95% CI 0·70 to 0·99, p=0·037). This mortality benefit was similar across subgroups by setting and type of infection (pinteractions>0·05), although mortality was very low in primary care and in patients with acute bronchitis. Procalcitonin guidance was also associated with a 2·4-day reduction in antibiotic exposure (5·7 vs 8·1 days 95% CI −2·71 to −2·15, p<0·0001) and a reduction in antibiotic-related side-effects (16% vs 22%, adjusted OR 0·68 95% CI 0·57 to 0·82, p<0·0001).
Interpretation
Use of procalcitonin to guide antibiotic treatment in patients with acute respiratory infections reduces antibiotic exposure and side-effects, and improves survival. Widespread implementation of procalcitonin protocols in patients with acute respiratory infections thus has the potential to improve antibiotic management with positive effects on clinical outcomes and on the current threat of increasing antibiotic multiresistance
The Lancet Infectious Diseases
Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis
Use of procalcitonin to guide antibiotic treatment in patients with acute respiratory
infections reduces antibiotic exposure and side-effects, and improves survival. Widespread
implementation of procalcitonin protocols in patients with acute respiratory infections…
infections reduces antibiotic exposure and side-effects, and improves survival. Widespread
implementation of procalcitonin protocols in patients with acute respiratory infections…
Elevated serum #procalcitonin levels and their association with the prognosis of patients with liver #cirrhosis
https://2medical.news/2020/08/13/elevated-serum-procalcitonin-levels-and-their-association-with-the-prognosis-of-patients-with-liver-cirrhosis/
Bacterial infection is a major complication in patients with liver cirrhosis. Procalcitonin is an early diagnostic marker of bacterial infection. This study aimed to investigate the association between the serum procalcitonin levels and the prognosis of patients with liver cirrhosis.. The serum procalcitonin level was higher (≥0.05 ng/mL) in 151 (64%) patients, and it was significantly higher in the patients with Child-Turcotte-Pugh class C than in …
https://2medical.news/2020/08/13/elevated-serum-procalcitonin-levels-and-their-association-with-the-prognosis-of-patients-with-liver-cirrhosis/
Bacterial infection is a major complication in patients with liver cirrhosis. Procalcitonin is an early diagnostic marker of bacterial infection. This study aimed to investigate the association between the serum procalcitonin levels and the prognosis of patients with liver cirrhosis.. The serum procalcitonin level was higher (≥0.05 ng/mL) in 151 (64%) patients, and it was significantly higher in the patients with Child-Turcotte-Pugh class C than in …
Serum #procalcitonin levels associate with #Clostridioides difficile infection in patients with #inflammatory bowel disease
https://2medical.news/2021/11/01/serum-procalcitonin-levels-associate-with-clostridioides-difficile-infection-in-patients-with-inflammatory-bowel-disease/
https://2medical.news/2021/11/01/serum-procalcitonin-levels-associate-with-clostridioides-difficile-infection-in-patients-with-inflammatory-bowel-disease/
2Medical.News
Serum #procalcitonin levels associate with #Clostridioides difficile infection in patients with #inflammatory bowel disease
Clostridioides difficile infection (CDI) is a major cause of morbidity among patients with inflammatory bowel disease (IBD). Diagnostic biomarkers for early detection of CDI are needed in clinical …