Extra-virgin #olive oil ameliorates #cognition and neuropathology of the 3xTg mice: role of autophagy
http://onlinelibrary.wiley.com/doi/10.1002/acn3.431/full

Consumption of extra virgin olive oil (EVOO), a major component of the Mediterranean diet, has been associated with reduced incidence of Alzheimer's disease (AD). However, the mechanisms involved in this protective action remain to be fully elucidated. Interpretation

Taken together, our findings support a beneficial effect of EVOO consumption on all major features of the AD phenotype (behavioral deficits, synaptic pathology, Aβ and tau neuropathology), and demonstrate that autophagy activation is the mechanism underlying these biological actions.

Enhancing Human #Cognition with #Cocoa Flavonoids

http://journal.frontiersin.org/article/10.3389/fnut.2017.00019/full

Enhancing cognitive abilities has become a fascinating scientific challenge, recently driven by the interest in preventing age-related cognitive decline and sustaining normal cognitive performance in response to cognitively demanding environments. In recent years, cocoa and cocoa-derived products, as a rich source of flavonoids, mainly the flavanols sub-class, have been clearly shown to exert cardiovascular benefits. More recently, neuromodulation and neuroprotective actions have been also suggested..
Although still at a preliminary stage, research investigating the relations between cocoa and cognition shows dose-dependent improvements in general cognition, attention, processing speed, and working memory. Moreover, cocoa flavanols administration could also enhance normal cognitive functioning and exert a protective role on cognitive performance and cardiovascular function specifically impaired by sleep loss, in healthy subjects. Together, these findings converge at pointing to cocoa as a new interesting nutraceutical tool to protect human cognition and counteract different types of cognitive decline, thus encouraging further investigations.

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Age at #menopause and lifetime #cognition
Findings from a British birth cohort study

http://n.neurology.org/content/early/2018/04/11/WNL.0000000000005486

Verbal memory increased with later age at natural menopause (0.17 words per year, 95% confidence interval CI: 0.07–0.27, p = 0.001); an association remained, albeit attenuated, after full adjustment (0.09, 95% CI: 0.02–0.17, p = 0.013). Verbal memory also increased with later age at surgical menopause (0.16, 95% CI: 0.06–0.27, p = 0.002), but this association was fully attenuated after adjustment. Search speed was not associated with age at menopause.

Conclusion Our findings suggest lifelong hormonal processes, not just short-term fluctuations during the menopause transition, may be associated with verbal memory, consistent with evidence from a variety of neurobiological studies; mechanisms are likely to involve estrogen receptor β function. Further follow-up is required to assess fully the clinical significance of these associations

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Associations between 24 hour #movement behaviours and global #cognition in US children: a cross-sectional observational study

https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(18)30278-5/fulltext

The Canadian 24-Hour Movement Guidelines for Children and Youth recommend at least 60 min physical activity per day, 2 h or less recreational screen time per day, and 9–11 h sleep per night in children aged 8–11 years. We investigated the relationship between adherence to these recommendations and global cognition

Global cognition was positively associated with each additional recommendation met (β=1·44, 95% CI 0·82–2·07, p<0·0001). Compared with meeting none of the recommendations, associations with superior global cognition were found in participants who met all three recommendations (β=3·89, 95% CI 1·43 to 6·34, p=0·0019), the screen time recommendation only (β=4·25, 2·50–6·01, p<0·0001), and both the screen time and the sleep recommendations (β=5·15, 3·56–6·74, p<0·0001).

Interpretation
Meeting the 24 h movement recommendations was associated with superior global cognition. These findings highlight the importance of limiting recreational screen time and encouraging healthy sleep to improve cognition in children.

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Effects of blood #pressure and #lipid lowering on #cognition
Results from the HOPE-3 study

http://n.neurology.org/content/early/2019/02/27/WNL.0000000000007174

Compared with placebo, candesartan/hydrochlorothiazide reduced systolic blood pressure by 6.0 mm Hg, and rosuvastatin reduced low-density lipoprotein cholesterol by 24.8 mg/dL. Participants were followed up for 5.7 years (median), and 1,626 completed both baseline and study-end assessments. Mean participant age was 74 years (SD ±3.5 years); 59% were women; 45% had hypertension; and 24% had ≥12 years of education. The mean difference in change in DSST scores was −0.91 (95% confidence interval CI −2.25 to 0.42) for candesartan/hydrochlorothiazide compared with placebo, −0.54 (95% CI −1.88 to 0.80) for rosuvastatin compared with placebo, and −1.43 (95% CI −3.37 to 0.50) for combination therapy vs double placebo. No significant differences were found for other measures.

Conclusions Long-term blood pressure lowering with candesartan plus hydrochlorothiazide, rosuvastatin, or their combination did not significantly affect cognitive decline in older people

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The “online brain”: how the #Internet may be changing our #cognition

https://onlinelibrary.wiley.com/doi/full/10.1002/wps.20617

Here we draw on recent psychological, psychiatric and neuroimaging findings to examine several key hypotheses on how the Internet may be changing our cognition. Specifically, we explore how unique features of the online world may be influencing: a) attentional capacities, as the constantly evolving stream of online information encourages our divided attention across multiple media sources, at the expense of sustained concentration; b) memory processes, as this vast and ubiquitous source of online information begins to shift the way we retrieve, store, and even value knowledge; and c) social cognition, as the ability for online social settings to resemble and evoke real‐world social processes creates a new interplay between the Internet and our social lives, including our self‐concepts and self‐esteem.

Overall, the available evidence indicates that the Internet can produce both acute and sustained alterations in each of these areas of cognition, which may be reflected in changes in the brain. However, an emerging priority for future research is to determine the effects of extensive online media usage on cognitive development in youth, and examine how this may differ from cognitive outcomes and brain impact of uses of Internet in the elderly.

We conclude by proposing how Internet research could be integrated into broader research settings to study how this unprecedented new facet of society can affect our cognition and the brain across the life course.

Effect of #gut #microbiome modulation on #muscle function and #cognition: the PROMOTe randomised controlled trial

https://2medical.news/2024/03/12/effect-of-gut-microbiome-modulation-on-muscle-function-and-cognition-the-promote-randomised-controlled-trial/