Hypothermic oxygenated machine perfusion reduces #bile duct reperfusion injury after #transplantation of donation after circulatory death livers
http://onlinelibrary.wiley.com/doi/10.1002/lt.25023/abstract
Dual hypothermic oxygenated machine perfusion (DHOPE) of the liver has been advocated as a method to reduce ischemia-reperfusion injury. This study aimed to determine whether DHOPE reduces IR injury of the bile ducts in DCD liver transplantation Baseline characteristics and the degree of bile duct injury at baseline (end of SCS) were similar between both groups. In controls, degree of stroma necrosis (P=0.002) and injury of the deep peribiliary glands (P=0.02) increased after reperfusion, compared to baseline. In contrast, in DHOPE preserved livers the degree of bile duct injury did not increase after reperfusion. Moreover, there was less injury of deep peribiliary glands (P=0.04) after reperfusion in the DHOPE group, compared to controls.
Conclusion: This study suggests that DHOPE reduces ischemia-reperfusion injury of bile ducts after DCD liver transplantation
http://onlinelibrary.wiley.com/doi/10.1002/lt.25023/abstract
Dual hypothermic oxygenated machine perfusion (DHOPE) of the liver has been advocated as a method to reduce ischemia-reperfusion injury. This study aimed to determine whether DHOPE reduces IR injury of the bile ducts in DCD liver transplantation Baseline characteristics and the degree of bile duct injury at baseline (end of SCS) were similar between both groups. In controls, degree of stroma necrosis (P=0.002) and injury of the deep peribiliary glands (P=0.02) increased after reperfusion, compared to baseline. In contrast, in DHOPE preserved livers the degree of bile duct injury did not increase after reperfusion. Moreover, there was less injury of deep peribiliary glands (P=0.04) after reperfusion in the DHOPE group, compared to controls.
Conclusion: This study suggests that DHOPE reduces ischemia-reperfusion injury of bile ducts after DCD liver transplantation
Wiley
Hypothermic oxygenated machine perfusion reduces bile duct reperfusion injury after transplantation of donation after circulatory…
Introduction: Dual hypothermic oxygenated machine perfusion (DHOPE) of the liver has been advocated as a method to reduce ischemia‐reperfusion injury. This study aimed to determine whether DHOPE reduces...
#Bile Acids Signal via TGR5 to Activate #Intestinal Stem Cells and Epithelial Regeneration
https://2medical.news/2020/09/23/bile-acids-signal-via-tgr5-to-activate-intestinal-stem-cells-and-epithelial-regeneration/
Renewal and patterning of the intestinal epithelium is coordinated by intestinal stem cells (ISCs); dietary and metabolic factors provide signals to the niche that control ISC activity. Bile acids (BAs), metabolites in the gut, signal nutrient availability by activating the G protein-coupled bile acid receptor 1 (GPBAR1, also called TGR5). TGR5 is expressed in the intestinal epithelium, but it is not clear how its activation …
https://2medical.news/2020/09/23/bile-acids-signal-via-tgr5-to-activate-intestinal-stem-cells-and-epithelial-regeneration/
Renewal and patterning of the intestinal epithelium is coordinated by intestinal stem cells (ISCs); dietary and metabolic factors provide signals to the niche that control ISC activity. Bile acids (BAs), metabolites in the gut, signal nutrient availability by activating the G protein-coupled bile acid receptor 1 (GPBAR1, also called TGR5). TGR5 is expressed in the intestinal epithelium, but it is not clear how its activation …