#Coffee—Antihypertensive Drug Interaction: A #Hemodynamic and Pharmacokinetic Study With Felodipine
http://m.ajh.oxfordjournals.org/content/early/2016/08/01/ajh.hpw081.abstract?sid=6bbdff87-98a0-4e62-954b-90ddc871cd02
CONCLUSION Intermittent coffee ingestion might complicate hypertension diagnosis and management for many individuals.
http://m.ajh.oxfordjournals.org/content/early/2016/08/01/ajh.hpw081.abstract?sid=6bbdff87-98a0-4e62-954b-90ddc871cd02
CONCLUSION Intermittent coffee ingestion might complicate hypertension diagnosis and management for many individuals.
The association between #coffee consumption and #bladder cancer incidence in a pooled analysis of the Miyagi Cohort Study and Ohsaki Cohort Study
http://journals.lww.com/eurjcancerprev/Abstract/2017/03000/The_association_between_coffee_consumption_and.3.aspx
The multivariate-adjusted hazard ratios (95% confidence intervals) of bladder cancer incidence for the individuals who drank coffee occasionally, 1–2 cups/day, and 3 or more cups/day compared with never drinkers were 1.22 (0.90–1.66), 0.88 (0.61–1.26), and 0.56 (0.32–0.99), respectively (Ptrend=0.04). The inverse association remained even after stratification for smoking status. These data indicate that there is a significant inverse association between coffee consumption and the risk of bladder cancer.
http://journals.lww.com/eurjcancerprev/Abstract/2017/03000/The_association_between_coffee_consumption_and.3.aspx
The multivariate-adjusted hazard ratios (95% confidence intervals) of bladder cancer incidence for the individuals who drank coffee occasionally, 1–2 cups/day, and 3 or more cups/day compared with never drinkers were 1.22 (0.90–1.66), 0.88 (0.61–1.26), and 0.56 (0.32–0.99), respectively (Ptrend=0.04). The inverse association remained even after stratification for smoking status. These data indicate that there is a significant inverse association between coffee consumption and the risk of bladder cancer.
Associations of #Coffee, #Tea, and Caffeine Intake with #Coronary Artery Calcification and Cardiovascular Events
http://www.amjmed.com/article/S0002-9343(16)30925-1/abstract
Over a median follow-up of 5.3 years for coronary artery calcium and 11.1 years for cardiovascular events, participants who regularly drank tea (≥1 cup per day) had a slower progression of coronary artery calcium compared with never drinkers after multivariable adjustment. This correlated with a statistically significant lower incidence of cardiovascular events for ≥1 cup per day tea drinkers (adjusted hazard ratio 0.71; 95% confidence interval 0.53-0.95). Compared with never coffee drinkers, regular coffee intake (≥1 cup per day) was not statistically associated with coronary artery calcium progression or cardiovascular events (adjusted hazard ratio 0.97; 95% confidence interval 0.78-1.20). Caffeine intake was marginally inversely associated with coronary artery calcium progression.
http://www.amjmed.com/article/S0002-9343(16)30925-1/abstract
Over a median follow-up of 5.3 years for coronary artery calcium and 11.1 years for cardiovascular events, participants who regularly drank tea (≥1 cup per day) had a slower progression of coronary artery calcium compared with never drinkers after multivariable adjustment. This correlated with a statistically significant lower incidence of cardiovascular events for ≥1 cup per day tea drinkers (adjusted hazard ratio 0.71; 95% confidence interval 0.53-0.95). Compared with never coffee drinkers, regular coffee intake (≥1 cup per day) was not statistically associated with coronary artery calcium progression or cardiovascular events (adjusted hazard ratio 0.97; 95% confidence interval 0.78-1.20). Caffeine intake was marginally inversely associated with coronary artery calcium progression.
#Coffee drinking and #Mortality in 10 European Countries: A Multinational Cohort Study
http://annals.org/aim/article/2643435/coffee-drinking-mortality-10-european-countries-multinational-cohort-study
The relationship between coffee consumption and mortality in diverse European populations with variable coffee preparation methods is unclear. In the EPIC Biomarkers subcohort, higher coffee consumption was associated with lower serum alkaline phosphatase; alanine aminotransferase; aspartate aminotransferase; γ-glutamyltransferase; and, in women, C-reactive protein, lipoprotein(a), and glycated hemoglobin levels.
Coffee drinking was associated with reduced risk for death from various causes. This relationship did not vary by country.
http://annals.org/aim/article/2643435/coffee-drinking-mortality-10-european-countries-multinational-cohort-study
The relationship between coffee consumption and mortality in diverse European populations with variable coffee preparation methods is unclear. In the EPIC Biomarkers subcohort, higher coffee consumption was associated with lower serum alkaline phosphatase; alanine aminotransferase; aspartate aminotransferase; γ-glutamyltransferase; and, in women, C-reactive protein, lipoprotein(a), and glycated hemoglobin levels.
Coffee drinking was associated with reduced risk for death from various causes. This relationship did not vary by country.
#Coffee intake and incidence of #erectile dysfunction
https://academic.oup.com/aje/article-abstract/4093018/Coffee-intake-and-incidence-of-erectile
Coffee intake is suggested to have a positive role against chronic diseases. Yet, the role of coffee in urological diseases such as erectile dysfunction (ED) remains unclear. Thus, we investigated the association of coffee intake with incidence of ED. No significant differences were identified for incident ED after comparing highest (≥ 4 cups/day) with lowest category (0 cups/day) of total- (HR = 1.00; 95% CI: 0.90 – 1.11) and regular- coffee intakes (HR = 1.00; 95% CI: 0.89 – 1.13). For decaffeinated coffee intake, after comparing the highest category with lowest category, we found a 37% increased risk of ED (HR = 1.37; 95% CI = 1.08-1.73) with a significant trend (Ptrend = 0.02). Stratified analyses showed an association among current smokers (Ptrend = 0.005).
Overall, long-term coffee intake was not associated with risk of ED in a prospective cohort study
https://academic.oup.com/aje/article-abstract/4093018/Coffee-intake-and-incidence-of-erectile
Coffee intake is suggested to have a positive role against chronic diseases. Yet, the role of coffee in urological diseases such as erectile dysfunction (ED) remains unclear. Thus, we investigated the association of coffee intake with incidence of ED. No significant differences were identified for incident ED after comparing highest (≥ 4 cups/day) with lowest category (0 cups/day) of total- (HR = 1.00; 95% CI: 0.90 – 1.11) and regular- coffee intakes (HR = 1.00; 95% CI: 0.89 – 1.13). For decaffeinated coffee intake, after comparing the highest category with lowest category, we found a 37% increased risk of ED (HR = 1.37; 95% CI = 1.08-1.73) with a significant trend (Ptrend = 0.02). Stratified analyses showed an association among current smokers (Ptrend = 0.005).
Overall, long-term coffee intake was not associated with risk of ED in a prospective cohort study
OUP Academic
Coffee intake and incidence of erectile dysfunction | American Journal of Epidemiology | Oxford Academic
Coffee intake is suggested to have a positive role against chronic diseases. Yet, the role of coffee in urological diseases such as erectile dysfunction (ED) remains unclear. Thus, we investigated the association of coffee intake with incidence of ED.A prospective…
#Coffee consumption and #health: umbrella review of meta-analyses of multiple health outcomes
http://www.bmj.com/content/359/bmj.j5024
Coffee consumption was more often associated with benefit than harm for a range of health outcomes across exposures including high versus low, any versus none, and one extra cup a day. There was evidence of a non-linear association between consumption and some outcomes, with summary estimates indicating largest relative risk reduction at intakes of three to four cups a day versus none, including all cause mortality (relative risk 0.83, 95% confidence interval 0.83 to 0.88), cardiovascular mortality (0.81, 0.72 to 0.90), and cardiovascular disease (0.85, 0.80 to 0.90). High versus low consumption was associated with an 18% lower risk of incident cancer (0.82, 0.74 to 0.89). Consumption was also associated with a lower risk of several specific cancers and neurological, metabolic, and liver conditions. Harmful associations were largely nullified by adequate adjustment for smoking, except in pregnancy, where high versus low/no consumption was associated with low birth weight (odds ratio 1.31, 95% confidence interval 1.03 to 1.67), preterm birth in the first (1.22, 1.00 to 1.49) and second (1.12, 1.02 to 1.22) trimester, and pregnancy loss (1.46, 1.06 to 1.99). There was also an association between coffee drinking and risk of fracture in women but not in men.
Conclusion Coffee consumption seems generally safe within usual levels of intake, with summary estimates indicating largest risk reduction for various health outcomes at three to four cups a day, and more likely to benefit
http://www.bmj.com/content/359/bmj.j5024
Coffee consumption was more often associated with benefit than harm for a range of health outcomes across exposures including high versus low, any versus none, and one extra cup a day. There was evidence of a non-linear association between consumption and some outcomes, with summary estimates indicating largest relative risk reduction at intakes of three to four cups a day versus none, including all cause mortality (relative risk 0.83, 95% confidence interval 0.83 to 0.88), cardiovascular mortality (0.81, 0.72 to 0.90), and cardiovascular disease (0.85, 0.80 to 0.90). High versus low consumption was associated with an 18% lower risk of incident cancer (0.82, 0.74 to 0.89). Consumption was also associated with a lower risk of several specific cancers and neurological, metabolic, and liver conditions. Harmful associations were largely nullified by adequate adjustment for smoking, except in pregnancy, where high versus low/no consumption was associated with low birth weight (odds ratio 1.31, 95% confidence interval 1.03 to 1.67), preterm birth in the first (1.22, 1.00 to 1.49) and second (1.12, 1.02 to 1.22) trimester, and pregnancy loss (1.46, 1.06 to 1.99). There was also an association between coffee drinking and risk of fracture in women but not in men.
Conclusion Coffee consumption seems generally safe within usual levels of intake, with summary estimates indicating largest risk reduction for various health outcomes at three to four cups a day, and more likely to benefit
The BMJ
Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes
Objectives To evaluate the existing evidence for associations between coffee consumption and multiple health outcomes.
Design Umbrella review of the evidence across meta-analyses of observational and interventional studies of coffee consumption and any…
Design Umbrella review of the evidence across meta-analyses of observational and interventional studies of coffee consumption and any…
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Health Check: why do I get a #headache when I haven’t had my #coffee?
https://theconversation.com/health-check-why-do-i-get-a-headache-when-i-havent-had-my-coffee-100163
Caffeine is a stimulant. It quickly enters our brain and blocks the (adenosine) receptors that are responsible for dulling brain activity. By blocking the dulling of our brain, we feel a sense of invigoration, focus and subtle euphoria. These feelings can also enhance our performance of certain focused tasks, like driving or staying awake through the whole lecture.
By far the most common symptom of caffeine withdrawal is headaches. These are typically mild and short-lived, usually only lasting for a day or two, although they can sometimes last for up to week. They usually feel a bit like a tense band wrapped across your head and are sometimes called tension-type headaches as a result. However, caffeine withdrawal can also trigger a full-on migraine in some sufferers.
However, withdrawal can happen even in people who usually drink just a single cup every day who then forego caffeine. Equally, only three days of continuous coffee drinking is enough to make you feel bad when the coffee runs out..
Health Check: why do I get a #headache when I haven’t had my #coffee?
https://theconversation.com/health-check-why-do-i-get-a-headache-when-i-havent-had-my-coffee-100163
Caffeine is a stimulant. It quickly enters our brain and blocks the (adenosine) receptors that are responsible for dulling brain activity. By blocking the dulling of our brain, we feel a sense of invigoration, focus and subtle euphoria. These feelings can also enhance our performance of certain focused tasks, like driving or staying awake through the whole lecture.
By far the most common symptom of caffeine withdrawal is headaches. These are typically mild and short-lived, usually only lasting for a day or two, although they can sometimes last for up to week. They usually feel a bit like a tense band wrapped across your head and are sometimes called tension-type headaches as a result. However, caffeine withdrawal can also trigger a full-on migraine in some sufferers.
However, withdrawal can happen even in people who usually drink just a single cup every day who then forego caffeine. Equally, only three days of continuous coffee drinking is enough to make you feel bad when the coffee runs out..
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Understanding the role of #bitter taste perception in #coffee, tea and alcohol consumption through Mendelian randomization
https://www.nature.com/articles/s41598-018-34713-z
A standard deviation (SD) higher in genetically predicted bitterness of caffeine was associated with increased coffee intake (0.146 95%CI: 0.103, 0.189 cups/day), whereas a SD higher in those of PROP and quinine was associated with decreased coffee intake (−0.021 −0.031, −0.011 and −0.081 −0.108, −0.054 cups/day respectively). Higher caffeine perception was also associated with increased risk of being a heavy (>4 cups/day) coffee drinker (OR 1.207 1.126, 1.294). Opposite pattern of associations was observed for tea possibly due to the inverse relationship between both beverages. Alcohol intake was only negatively associated with PROP perception (−0.141 −1.88, −0.94 times/month per SD increase in PROP bitterness).
Our results reveal that bitter perception is causally associated with intake of coffee, tea and alcohol, suggesting a role of bitter taste in the development of bitter beverage consumption.
Understanding the role of #bitter taste perception in #coffee, tea and alcohol consumption through Mendelian randomization
https://www.nature.com/articles/s41598-018-34713-z
A standard deviation (SD) higher in genetically predicted bitterness of caffeine was associated with increased coffee intake (0.146 95%CI: 0.103, 0.189 cups/day), whereas a SD higher in those of PROP and quinine was associated with decreased coffee intake (−0.021 −0.031, −0.011 and −0.081 −0.108, −0.054 cups/day respectively). Higher caffeine perception was also associated with increased risk of being a heavy (>4 cups/day) coffee drinker (OR 1.207 1.126, 1.294). Opposite pattern of associations was observed for tea possibly due to the inverse relationship between both beverages. Alcohol intake was only negatively associated with PROP perception (−0.141 −1.88, −0.94 times/month per SD increase in PROP bitterness).
Our results reveal that bitter perception is causally associated with intake of coffee, tea and alcohol, suggesting a role of bitter taste in the development of bitter beverage consumption.
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#Coffee cues elevate #arousal and reduce level of construal
https://www.sciencedirect.com/science/article/pii/S1053810018303350?via%3Dihub
Coffee and tea are two beverages commonly-consumed around the world. Therefore, there is much research regarding their physiological effects. However, less is known about their psychological meanings.
Derived from a predicted lay association between coffee and arousal, we posit that exposure to coffee-related cues should increase arousal, even in the absence of actual ingestion, relative to exposure to tea-related cues. We further suggest that higher arousal levels should facilitate a concrete level of mental construal as conceptualized by Construal Level Theory.
In four experiments, we find that coffee cues prompted participants to see temporal distances as shorter and to think in more concrete, precise terms. Both subjective and physiological arousal explain the effects. We situate our work in the literature that connects food and beverage to cognition or decision-making. We also discuss the applied relevance of our results as coffee and tea are among the most prevalent beverages globally.
#Coffee cues elevate #arousal and reduce level of construal
https://www.sciencedirect.com/science/article/pii/S1053810018303350?via%3Dihub
Coffee and tea are two beverages commonly-consumed around the world. Therefore, there is much research regarding their physiological effects. However, less is known about their psychological meanings.
Derived from a predicted lay association between coffee and arousal, we posit that exposure to coffee-related cues should increase arousal, even in the absence of actual ingestion, relative to exposure to tea-related cues. We further suggest that higher arousal levels should facilitate a concrete level of mental construal as conceptualized by Construal Level Theory.
In four experiments, we find that coffee cues prompted participants to see temporal distances as shorter and to think in more concrete, precise terms. Both subjective and physiological arousal explain the effects. We situate our work in the literature that connects food and beverage to cognition or decision-making. We also discuss the applied relevance of our results as coffee and tea are among the most prevalent beverages globally.
Association of #Coffee Intake With Survival in Patients With Advanced or Metastatic #Colorectal Cancer
https://2medical.news/2020/09/21/association-of-coffee-intake-with-survival-in-patients-with-advanced-or-metastatic-colorectal-cancer/
Several compounds found in coffee possess antioxidant, anti-inflammatory, and insulin-sensitizing effects, which may contribute to anticancer activity. Epidemiological studies have identified associations between increased coffee consumption and decreased recurrence and mortality of colorectal cancer. The association between coffee consumption and survival in patients with advanced or metastatic colorectal cancer is unknown.. ..Among the 1171 patients included in the analysis (694 men [59%]; median age, 59 …
https://2medical.news/2020/09/21/association-of-coffee-intake-with-survival-in-patients-with-advanced-or-metastatic-colorectal-cancer/
Several compounds found in coffee possess antioxidant, anti-inflammatory, and insulin-sensitizing effects, which may contribute to anticancer activity. Epidemiological studies have identified associations between increased coffee consumption and decreased recurrence and mortality of colorectal cancer. The association between coffee consumption and survival in patients with advanced or metastatic colorectal cancer is unknown.. ..Among the 1171 patients included in the analysis (694 men [59%]; median age, 59 …
Additive effects of green #tea and #coffee on all-cause mortality in patients with type 2 #diabetes mellitus: the Fukuoka Diabetes Registry
https://2medical.news/2020/10/23/additive-effects-of-green-tea-and-coffee-on-all-cause-mortality-in-patients-with-type-2-diabetes-mellitus-the-fukuoka-diabetes-registry/
The impact of consuming green tea or coffee on mortality in patients with diabetes is controversial. We prospectively investigated the impact of each beverage and their combination on mortality among Japanese patients with type 2 diabetes.. ..During the follow-up period, 309 participants died. The consumption of green tea, coffee, and a combination of the beverages was associated with reduced all-cause mortality. Multivariable-adjusted hazard ratios (95% …
https://2medical.news/2020/10/23/additive-effects-of-green-tea-and-coffee-on-all-cause-mortality-in-patients-with-type-2-diabetes-mellitus-the-fukuoka-diabetes-registry/
The impact of consuming green tea or coffee on mortality in patients with diabetes is controversial. We prospectively investigated the impact of each beverage and their combination on mortality among Japanese patients with type 2 diabetes.. ..During the follow-up period, 309 participants died. The consumption of green tea, coffee, and a combination of the beverages was associated with reduced all-cause mortality. Multivariable-adjusted hazard ratios (95% …
#Coffee consumption and risk of #prostate cancer: a systematic review and meta-analysis
https://2medical.news/2021/01/17/coffee-consumption-and-risk-of-prostate-cancer-a-systematic-review-and-meta-analysis/
To conduct a systematic review with meta-analysis of cohort studies to evaluate the association of coffee consumption with the risk of prostate cancer.. ..Sixteen prospective cohort studies were finally included, with 57 732 cases of prostate cancer and 1 081 586 total cohort members. Higher coffee consumption was significantly associated with a lower risk of prostate cancer. Compared with the lowest category of coffee consumption, the pooled relative …
https://2medical.news/2021/01/17/coffee-consumption-and-risk-of-prostate-cancer-a-systematic-review-and-meta-analysis/
To conduct a systematic review with meta-analysis of cohort studies to evaluate the association of coffee consumption with the risk of prostate cancer.. ..Sixteen prospective cohort studies were finally included, with 57 732 cases of prostate cancer and 1 081 586 total cohort members. Higher coffee consumption was significantly associated with a lower risk of prostate cancer. Compared with the lowest category of coffee consumption, the pooled relative …
#Cardiovascular symptoms affect the patterns of habitual #coffee consumption
https://2medical.news/2021/05/13/cardiovascular-symptoms-affect-the-patterns-of-habitual-coffee-consumption/
https://2medical.news/2021/05/13/cardiovascular-symptoms-affect-the-patterns-of-habitual-coffee-consumption/
2Medical.News
#Cardiovascular symptoms affect the patterns of habitual #coffee consumption
Excessive coffee consumption can lead to unpleasant sensations such as tachycardia and heart palpitations. ObjectivesOur aim was to investigate if cardiovascular symptoms can lead to alterations in…
All #coffee types decrease the risk of adverse clinical outcomes in chronic #liver disease: a UK Biobank study
https://2medical.news/2021/06/22/all-coffee-types-decrease-the-risk-of-adverse-clinical-outcomes-in-chronic-liver-disease-a-uk-biobank-study/
https://2medical.news/2021/06/22/all-coffee-types-decrease-the-risk-of-adverse-clinical-outcomes-in-chronic-liver-disease-a-uk-biobank-study/
2Medical.News
All #coffee types decrease the risk of adverse clinical outcomes in chronic #liver disease: a UK Biobank study
Chronic liver disease (CLD) is a growing cause of morbidity and mortality worldwide, particularly in low to middle-income countries with high disease burden and limited treatment availability. Coff…
Changes in #Coffee Intake, Added #Sugar and Long-Term #Weight Gain – Results from Three Large Prospective US Cohort Studies
https://2medical.news/2023/10/18/changes-in-coffee-intake-added-sugar-and-long-term-weight-gain-results-from-three-large-prospective-us-cohort-studies/
https://2medical.news/2023/10/18/changes-in-coffee-intake-added-sugar-and-long-term-weight-gain-results-from-three-large-prospective-us-cohort-studies/
2Medical.News
Changes in #Coffee Intake, Added #Sugar and Long-Term #Weight Gain – Results from Three Large Prospective US Cohort Studies
BackgroundConsumption of both caffeinated and decaffeinated coffee has been reported to attenuate long-term weight gain. Whether the association between coffee consumption and weight gain depends o…
Use of #sugar in #coffee and #tea and long-term risk of #mortality in older adult Danish men: 32 years of follow-up from a prospective cohort study
https://2medical.news/2023/10/31/use-of-sugar-in-coffee-and-tea-and-long-term-risk-of-mortality-in-older-adult-danish-men-32-years-of-follow-up-from-a-prospective-cohort-study/
https://2medical.news/2023/10/31/use-of-sugar-in-coffee-and-tea-and-long-term-risk-of-mortality-in-older-adult-danish-men-32-years-of-follow-up-from-a-prospective-cohort-study/
2Medical.News
Use of #sugar in #coffee and #tea and long-term risk of #mortality in older adult Danish men: 32 years of follow-up from a prospective…
Tea and coffee are the most consumed beverages worldwide and very often sweetened with sugar. However, the association between the use of sugar in tea or coffee and adverse events is currently uncl…
Examining the Association between #Coffee Intake and the Risk of Developing #Irritable #Bowel Syndrome: A Systematic Review and Meta-Analysis
https://2medical.news/2023/12/05/examining-the-association-between-coffee-intake-and-the-risk-of-developing-irritable-bowel-syndrome-a-systematic-review-and-meta-analysis/
https://2medical.news/2023/12/05/examining-the-association-between-coffee-intake-and-the-risk-of-developing-irritable-bowel-syndrome-a-systematic-review-and-meta-analysis/
2Medical.News
Examining the Association between #Coffee Intake and the Risk of Developing #Irritable #Bowel Syndrome: A Systematic Review and…
Abstract: Irritable bowel syndrome (IBS) is a highly prevalent disorder of braingut interaction with a significant impact on quality of life. Coffee is a widely consumed beverage with numerous bio…
Genome-wide association studies of #coffee intake in UK/US participants of European ancestry uncover cohort-specific #genetic associations
https://2medical.news/2024/07/17/genome-wide-association-studies-of-coffee-intake-in-uk-us-participants-of-european-ancestry-uncover-cohort-specific-genetic-associations/
https://2medical.news/2024/07/17/genome-wide-association-studies-of-coffee-intake-in-uk-us-participants-of-european-ancestry-uncover-cohort-specific-genetic-associations/
2Medical.News
Genome-wide association studies of #coffee intake in UK/US participants of European ancestry uncover cohort-specific #genetic associations
Coffee is one of the most widely consumed beverages. We performed a genome-wide association study (GWAS) of coffee intake in US-based 23andMe participants (N = 130,153) and identified 7 significant…