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#Microglial control of #astrocytes in response to microbial metabolites
https://www.nature.com/articles/s41586-018-0119-x
Microglia and astrocytes modulate inflammation and neurodegeneration in the central nervous system (CNS)1,2,3. Microglia modulate pro-inflammatory and neurotoxic activities in astrocytes, but the mechanisms involved are not completely understood
Finally, metabolites of dietary tryptophan produced by the commensal flora control microglial activation and TGFα and VEGF-B production, modulating the transcriptional program of astrocytes and CNS inflammation through a mechanism mediated by the aryl hydrocarbon receptor.
In summary, we identified positive and negative regulators that mediate the microglial control of astrocytes. Moreover, these findings define a pathway through which microbial metabolites limit pathogenic activities of microglia and astrocytes, and suppress CNS inflammation. This pathway may guide new therapies for multiple sclerosis and other neurological disorders
#Microglial control of #astrocytes in response to microbial metabolites
https://www.nature.com/articles/s41586-018-0119-x
Microglia and astrocytes modulate inflammation and neurodegeneration in the central nervous system (CNS)1,2,3. Microglia modulate pro-inflammatory and neurotoxic activities in astrocytes, but the mechanisms involved are not completely understood
Finally, metabolites of dietary tryptophan produced by the commensal flora control microglial activation and TGFα and VEGF-B production, modulating the transcriptional program of astrocytes and CNS inflammation through a mechanism mediated by the aryl hydrocarbon receptor.
In summary, we identified positive and negative regulators that mediate the microglial control of astrocytes. Moreover, these findings define a pathway through which microbial metabolites limit pathogenic activities of microglia and astrocytes, and suppress CNS inflammation. This pathway may guide new therapies for multiple sclerosis and other neurological disorders
Irisin reduces #amyloid-β by inducing the release of neprilysin from #astrocytes following downregulation of ERK-STAT3 signaling
https://2medical.news/2023/09/12/irisin-reduces-amyloid-%CE%B2-by-inducing-the-release-of-neprilysin-from-astrocytes-following-downregulation-of-erk-stat3-signaling/
https://2medical.news/2023/09/12/irisin-reduces-amyloid-%CE%B2-by-inducing-the-release-of-neprilysin-from-astrocytes-following-downregulation-of-erk-stat3-signaling/
2Medical.News
Irisin reduces #amyloid-β by inducing the release of neprilysin from #astrocytes following downregulation of ERK-STAT3 signaling
A pathological hallmark of Alzheimer’s disease (AD) is the deposition of amyloid-β (Aβ) protein in the brain. Physical exercise has been shown to reduce Aβ burden in various AD mouse models, but th…