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Association of #Hypertensive Disorders of Pregnancy With Risk of #Neurodevelopmental Disorders in Offspring
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2681643
Although research suggests an association between hypertensive disorders of pregnancy (HDP) and autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and other neurodevelopmental disorders in offspring, consensus is lacking
.. Ten studies reported estimates for ADHD. Six of these (including 1 395 605 participants) reported adjusted estimates, with a pooled adjusted OR of 1.29 (95% CI, 1.22-1.36). Subgroup analyses according to type of exposure (ie, preeclampsia or other HDP) showed no statistically significant differences for ASD or ADHD. Thirty-one studies met inclusion criteria for all other neurodevelopmental disorders. Individual estimates reported for these were largely inconsistent, with few patterns of association observed.
Conclusions and Relevance Exposure to HDP may be associated with an increase in the risk of ASD and ADHD. These findings highlight the need for greater pediatric surveillance of infants exposed to HDP to allow early intervention that may improve neurodevelopmental outcome
Association of #Hypertensive Disorders of Pregnancy With Risk of #Neurodevelopmental Disorders in Offspring
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2681643
Although research suggests an association between hypertensive disorders of pregnancy (HDP) and autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and other neurodevelopmental disorders in offspring, consensus is lacking
.. Ten studies reported estimates for ADHD. Six of these (including 1 395 605 participants) reported adjusted estimates, with a pooled adjusted OR of 1.29 (95% CI, 1.22-1.36). Subgroup analyses according to type of exposure (ie, preeclampsia or other HDP) showed no statistically significant differences for ASD or ADHD. Thirty-one studies met inclusion criteria for all other neurodevelopmental disorders. Individual estimates reported for these were largely inconsistent, with few patterns of association observed.
Conclusions and Relevance Exposure to HDP may be associated with an increase in the risk of ASD and ADHD. These findings highlight the need for greater pediatric surveillance of infants exposed to HDP to allow early intervention that may improve neurodevelopmental outcome
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Combined effect of work #stress and impaired sleep on coronary and cardiovascular mortality in #hypertensive workers: The MONICA/KORA cohort study
https://journals.sagepub.com/doi/10.1177/2047487319839183
Although work stress and impaired sleep are established risk factors for cardiovascular disease (CVD) among healthy individuals, their impact on hypertensive workers is largely unknown.
During a mean follow-up of 17.8 years covering 34,900 person-years, 134 fatal CVD and 73 coronary heart disease (CHD) events were observed. In comparison to participants with low work stress and non-impaired sleep, participants with work stress (hazard ratio (HR) 1.56, 95% CI 0.81-2.98), or impaired sleep (HR 1.76, 95% CI 0.96-3.22) had an increased risk of CVD, while participants with both work stress and impaired sleep had the highest risk of CVD mortality (HR 2.94, 95% CI 1.18-7.33). Participants with both risk conditions had an absolute CVD mortality risk of 7.13 cases per 1000 person-years in comparison to 3.05 cases per 1000-person years in the reference group. Similar risk patterns were found for CHD mortality.
Conclusions
Our findings add a new piece of evidence that work stress together with impaired sleep increase risk of coronary and cardiovascular mortality in hypertensive workers.
Combined effect of work #stress and impaired sleep on coronary and cardiovascular mortality in #hypertensive workers: The MONICA/KORA cohort study
https://journals.sagepub.com/doi/10.1177/2047487319839183
Although work stress and impaired sleep are established risk factors for cardiovascular disease (CVD) among healthy individuals, their impact on hypertensive workers is largely unknown.
During a mean follow-up of 17.8 years covering 34,900 person-years, 134 fatal CVD and 73 coronary heart disease (CHD) events were observed. In comparison to participants with low work stress and non-impaired sleep, participants with work stress (hazard ratio (HR) 1.56, 95% CI 0.81-2.98), or impaired sleep (HR 1.76, 95% CI 0.96-3.22) had an increased risk of CVD, while participants with both work stress and impaired sleep had the highest risk of CVD mortality (HR 2.94, 95% CI 1.18-7.33). Participants with both risk conditions had an absolute CVD mortality risk of 7.13 cases per 1000 person-years in comparison to 3.05 cases per 1000-person years in the reference group. Similar risk patterns were found for CHD mortality.
Conclusions
Our findings add a new piece of evidence that work stress together with impaired sleep increase risk of coronary and cardiovascular mortality in hypertensive workers.
Maternal #Hypertensive Pregnancy Disorders and #Mental Disorders in Children
https://2medical.news/2020/04/23/maternal-hypertensive-pregnancy-disorders-and-mental-disorders-in-children/
The associations of maternal hypertensive pregnancy disorders with offspring mental disorders remain unclear. We examined whether maternal hypertensive disorders and maximum blood pressure during pregnancy predict offspring childhood mental disorders, whether the associations are independent of maternal and paternal mental disorders and paternal hypertensive disorders, independent of or additive with maternal early pregnancy overweight/obesity and diabetes mellitus disorders, and mediated or moderated by preterm birth, …
https://2medical.news/2020/04/23/maternal-hypertensive-pregnancy-disorders-and-mental-disorders-in-children/
The associations of maternal hypertensive pregnancy disorders with offspring mental disorders remain unclear. We examined whether maternal hypertensive disorders and maximum blood pressure during pregnancy predict offspring childhood mental disorders, whether the associations are independent of maternal and paternal mental disorders and paternal hypertensive disorders, independent of or additive with maternal early pregnancy overweight/obesity and diabetes mellitus disorders, and mediated or moderated by preterm birth, …
Long-term risk of #stroke and myocardial #infarction in middle-aged men with a #hypertensive response to exercise: a 44-year follow-up study
https://2medical.news/2021/02/14/long-term-risk-of-stroke-and-myocardial-infarction-in-middle-aged-men-with-a-hypertensive-response-to-exercise-a-44-year-follow-up-study/
Data on the prognostic value of hypertensive response to exercise in cardiovascular disease are limited. The aim was to determine whether SBP reactions during exercise have any prognostic value in relation to the long-term risk of stroke and myocardial infarction (MI). Patients and methods: A representative cohort of men from Gothenburg, Sweden, born in 1913, who performed a maximum exercise test at age 54 years, …
https://2medical.news/2021/02/14/long-term-risk-of-stroke-and-myocardial-infarction-in-middle-aged-men-with-a-hypertensive-response-to-exercise-a-44-year-follow-up-study/
Data on the prognostic value of hypertensive response to exercise in cardiovascular disease are limited. The aim was to determine whether SBP reactions during exercise have any prognostic value in relation to the long-term risk of stroke and myocardial infarction (MI). Patients and methods: A representative cohort of men from Gothenburg, Sweden, born in 1913, who performed a maximum exercise test at age 54 years, …
Evaluation of serum #calcium differences in #hypertensive crises and control patients: A randomly matched case-control study
https://2medical.news/2021/07/31/evaluation-of-serum-calcium-differences-in-hypertensive-crises-and-control-patients-a-randomly-matched-case-control-study/
https://2medical.news/2021/07/31/evaluation-of-serum-calcium-differences-in-hypertensive-crises-and-control-patients-a-randomly-matched-case-control-study/
2Medical.News
Evaluation of serum #calcium differences in #hypertensive crises and control patients: A randomly matched case-control study
The role of calcium in blood pressure has been widely studied among hypertensive patients; however, no study has explored the role of calcium in hypertensive crises. The primary objective of this s…
Impact of #diverticular disease on #prostate cancer risk among #hypertensive men
https://2medical.news/2021/10/13/impact-of-diverticular-disease-on-prostate-cancer-risk-among-hypertensive-men/
https://2medical.news/2021/10/13/impact-of-diverticular-disease-on-prostate-cancer-risk-among-hypertensive-men/
2Medical.News
Impact of #diverticular disease on #prostate cancer risk among #hypertensive men
Prostate cancer (PCa) is a heterogenous disease with multiple etiological factors playing a role in its development. Recently, chronic and systemic inflammatory conditions such as inflammatory bowe…