!!
#Perimenstrual exacerbation of symptoms in borderline #personality disorder: evidence from multilevel models and the Carolina Premenstrual Assessment Scoring System
https://www.cambridge.org/core/journals/psychological-medicine/article/perimenstrual-exacerbation-of-symptoms-in-borderline-personality-disorder-evidence-from-multilevel-models-and-the-carolina-premenstrual-assessment-scoring-system/C3618015C8AFED6E6C1108A573869E3D
Most symptoms demonstrated midluteal worsening, a perimenstrual peak, and resolution of symptoms in the follicular or ovulatory phase. Post-hoc correlations with person-centered progesterone revealed negative correlations with most symptoms. Depressive symptoms showed an unexpected delayed pattern in which baseline levels of symptoms were observed in the ovulatory and midluteal phases, and exacerbations were observed during both the perimenstrual and follicular phases. The majority of participants met C-PASS criteria for clinically significant (⩾30%) symptom exacerbation. All participants met the emotional instability criterion of BPD, and no participant met DSM-5 criteria for premenstrual dysphoric disorder (PMDD).
Conclusions
Females with BPD may be at elevated risk for perimenstrual worsening of emotional symptoms. Longitudinal studies with fine-grained hormonal measurement as well as hormonal experiments are needed to determine the pathophysiology of perimenstrual exacerbation in BPD
#Perimenstrual exacerbation of symptoms in borderline #personality disorder: evidence from multilevel models and the Carolina Premenstrual Assessment Scoring System
https://www.cambridge.org/core/journals/psychological-medicine/article/perimenstrual-exacerbation-of-symptoms-in-borderline-personality-disorder-evidence-from-multilevel-models-and-the-carolina-premenstrual-assessment-scoring-system/C3618015C8AFED6E6C1108A573869E3D
Most symptoms demonstrated midluteal worsening, a perimenstrual peak, and resolution of symptoms in the follicular or ovulatory phase. Post-hoc correlations with person-centered progesterone revealed negative correlations with most symptoms. Depressive symptoms showed an unexpected delayed pattern in which baseline levels of symptoms were observed in the ovulatory and midluteal phases, and exacerbations were observed during both the perimenstrual and follicular phases. The majority of participants met C-PASS criteria for clinically significant (⩾30%) symptom exacerbation. All participants met the emotional instability criterion of BPD, and no participant met DSM-5 criteria for premenstrual dysphoric disorder (PMDD).
Conclusions
Females with BPD may be at elevated risk for perimenstrual worsening of emotional symptoms. Longitudinal studies with fine-grained hormonal measurement as well as hormonal experiments are needed to determine the pathophysiology of perimenstrual exacerbation in BPD