Effects of two personalized #dietary strategies during a 2‐year intervention in subjects with nonalcoholic #fatty #liver disease: a randomized trial
https://2medical.news/2021/02/12/effects-of-two-personalized-dietary-strategies-during-a-2%E2%80%90year-intervention-in-subjects-with-nonalcoholic-fatty-liver-disease-a-randomized-trial/
Background and objectives Nonalcoholic fatty liver disease (NAFLD) management is focused on lifestyle modifications, but long‐term maintenance is a challenge for many individuals. This study aimed to evaluate the long‐term effects of two personalized energy‐restricted dietary strategies on weight loss, metabolic and hepatic outcomes in overweight/obese subjects with NAFLD. Methods Ninety‐eight subjects from the Fatty Liver in Obesity (FLiO) study (NCT03183193) were randomly assigned to …
https://2medical.news/2021/02/12/effects-of-two-personalized-dietary-strategies-during-a-2%E2%80%90year-intervention-in-subjects-with-nonalcoholic-fatty-liver-disease-a-randomized-trial/
Background and objectives Nonalcoholic fatty liver disease (NAFLD) management is focused on lifestyle modifications, but long‐term maintenance is a challenge for many individuals. This study aimed to evaluate the long‐term effects of two personalized energy‐restricted dietary strategies on weight loss, metabolic and hepatic outcomes in overweight/obese subjects with NAFLD. Methods Ninety‐eight subjects from the Fatty Liver in Obesity (FLiO) study (NCT03183193) were randomly assigned to …
Acute #Liver Injury With Therapeutic Doses of #Acetaminophen: A Prospective Study
https://2medical.news/2021/04/02/acute-liver-injury-with-therapeutic-doses-of-acetaminophen-a-prospective-study/
Because of the extensive use of this drug, further evaluation of acute liver injury (ALI) with therapeutic doses of acetaminophen (APAP; ≤6 g/d) is required. We characterize ALI with therapeutic doses of APAP and determine the host factors associated with disease severity and the predictors of outcome. Approach and Results All patients admitted with severe APAP‐related ALI in our center were included from 2002 to …
https://2medical.news/2021/04/02/acute-liver-injury-with-therapeutic-doses-of-acetaminophen-a-prospective-study/
Because of the extensive use of this drug, further evaluation of acute liver injury (ALI) with therapeutic doses of acetaminophen (APAP; ≤6 g/d) is required. We characterize ALI with therapeutic doses of APAP and determine the host factors associated with disease severity and the predictors of outcome. Approach and Results All patients admitted with severe APAP‐related ALI in our center were included from 2002 to …
Acute on Chronic Liver Failure From #Nonalcoholic Fatty #Liver Disease: A Growing and Aging Cohort With Rising Mortality
https://2medical.news/2021/04/03/acute-on-chronic-liver-failure-from-nonalcoholic-fatty-liver-disease-a-growing-and-aging-cohort-with-rising-mortality/
We assessed the burden of nonalcoholic fatty liver disease (NAFLD)‐related acute on chronic liver failure (ACLF) among transplant candidates in the United States, along with waitlist outcomes for this population. Approach and Results We analyzed the United Network for Organ Sharing registry from 2005 to 2017. Patients with ACLF were identified using the European Association for the Study of the Liver/Chronic Liver Failure criteria and …
https://2medical.news/2021/04/03/acute-on-chronic-liver-failure-from-nonalcoholic-fatty-liver-disease-a-growing-and-aging-cohort-with-rising-mortality/
We assessed the burden of nonalcoholic fatty liver disease (NAFLD)‐related acute on chronic liver failure (ACLF) among transplant candidates in the United States, along with waitlist outcomes for this population. Approach and Results We analyzed the United Network for Organ Sharing registry from 2005 to 2017. Patients with ACLF were identified using the European Association for the Study of the Liver/Chronic Liver Failure criteria and …
Dose-response association between #adiposity and #liver cancer incidence: a prospective cohort study among non-smoking and non-alcohol drinking Chinese women
https://2medical.news/2021/04/21/dose-response-association-between-adiposity-and-liver-cancer-incidence-a-prospective-cohort-study-among-non-smoking-and-non-alcohol-drinking-chinese-women/
Background: Based on a population with very low prevalence of smoking and alcohol drinking, we examined the associations between overall obesity and fat distribution in middle age, obesity in early adulthood, and adult weight gain with the risk of liver cancer incidence. Methods: The associations between body mass index (BMI) at study enrollment and at age 20, waist circumference (WC), hip circumference (HC), waist-to-hip ratio …
https://2medical.news/2021/04/21/dose-response-association-between-adiposity-and-liver-cancer-incidence-a-prospective-cohort-study-among-non-smoking-and-non-alcohol-drinking-chinese-women/
Background: Based on a population with very low prevalence of smoking and alcohol drinking, we examined the associations between overall obesity and fat distribution in middle age, obesity in early adulthood, and adult weight gain with the risk of liver cancer incidence. Methods: The associations between body mass index (BMI) at study enrollment and at age 20, waist circumference (WC), hip circumference (HC), waist-to-hip ratio …
Genetic analysis in European ancestry individuals identifies 517 loci associated with #liver enzymes
https://2medical.news/2021/05/11/genetic-analysis-in-european-ancestry-individuals-identifies-517-loci-associated-with-liver-enzymes/
https://2medical.news/2021/05/11/genetic-analysis-in-european-ancestry-individuals-identifies-517-loci-associated-with-liver-enzymes/
2Medical.News
Genetic analysis in European ancestry individuals identifies 517 loci associated with #liver enzymes
Serum concentration of hepatic enzymes are linked to liver dysfunction, metabolic and cardiovascular diseases. We perform genetic analysis on serum levels of alanine transaminase (ALT), alkaline ph…
Development and prognostic relevance of a histologic grading and staging system for #alcohol-related #liver disease
https://2medical.news/2021/06/15/development-and-prognostic-relevance-of-a-histologic-grading-and-staging-system-for-alcohol-related-liver-disease/
https://2medical.news/2021/06/15/development-and-prognostic-relevance-of-a-histologic-grading-and-staging-system-for-alcohol-related-liver-disease/
2Medical.News
Development and prognostic relevance of a histologic grading and staging system for #alcohol-related #liver disease
The SALVE Histopathology Group (SHG) developed and validated a grading and staging system for the clinical and full histological spectrum of alcohol-related liver disease (ALD) and evaluated its pr…
All #coffee types decrease the risk of adverse clinical outcomes in chronic #liver disease: a UK Biobank study
https://2medical.news/2021/06/22/all-coffee-types-decrease-the-risk-of-adverse-clinical-outcomes-in-chronic-liver-disease-a-uk-biobank-study/
https://2medical.news/2021/06/22/all-coffee-types-decrease-the-risk-of-adverse-clinical-outcomes-in-chronic-liver-disease-a-uk-biobank-study/
2Medical.News
All #coffee types decrease the risk of adverse clinical outcomes in chronic #liver disease: a UK Biobank study
Chronic liver disease (CLD) is a growing cause of morbidity and mortality worldwide, particularly in low to middle-income countries with high disease burden and limited treatment availability. Coff…
#Statin liver safety in non-alcoholic fatty #liver disease. A systematic review and metanalysis
https://2medical.news/2021/06/30/statin-liver-safety-in-non-alcoholic-fatty-liver-disease-a-systematic-review-and-metanalysis/
https://2medical.news/2021/06/30/statin-liver-safety-in-non-alcoholic-fatty-liver-disease-a-systematic-review-and-metanalysis/
2Medical.News
#Statin liver safety in non-alcoholic fatty #liver disease. A systematic review and metanalysis
Statin liver safety in non-alcoholic fatty liver disease (NAFLD) patients is not well defined. We analysed differences in liver function tests, including alanine transaminase aminotransferase (ALT)…
Intact Fasting #Insulin Identifies Nonalcoholic Fatty #Liver Disease in Patients Without Diabetes
https://2medical.news/2021/07/10/intact-fasting-insulin-identifies-nonalcoholic-fatty-liver-disease-in-patients-without-diabetes/
https://2medical.news/2021/07/10/intact-fasting-insulin-identifies-nonalcoholic-fatty-liver-disease-in-patients-without-diabetes/
2Medical.News
Intact Fasting #Insulin Identifies Nonalcoholic Fatty #Liver Disease in Patients Without Diabetes
Patients with nonalcoholic fatty liver disease (NAFLD) are characterized by insulin resistance and hyperinsulinism. However, insulin resistance measurements have not been shown to be good diagnosti…
Incidence of #liver-related morbidity and mortality in a population cohort of non-alcoholic fatty liver disease
https://2medical.news/2021/07/11/incidence-of-liver-related-morbidity-and-mortality-in-a-population-cohort-of-non-alcoholic-fatty-liver-disease/
https://2medical.news/2021/07/11/incidence-of-liver-related-morbidity-and-mortality-in-a-population-cohort-of-non-alcoholic-fatty-liver-disease/
2Medical.News
Incidence of #liver-related morbidity and mortality in a population cohort of non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) increases morbidity and mortality. However, patients in biopsy-based cohorts are highly selected and the absolute risks of liver- and non-liver outcomes in…