#Periodontal Disease, Regular Dental Care Use, and Incident Ischemic #Stroke
http://stroke.ahajournals.org/content/early/2018/01/12/STROKEAHA.117.018990
..classified into 7 periodontal profile classes (PPCs) The 7 levels of PPC showed a trend toward an increased stroke risk (χ2 trend P<0.0001); the incidence rate for ischemic stroke/1000-person years was 1.29 for PPC-A (health), 2.82 for PPC-B, 4.80 for PPC-C, 3.81 for PPC-D, 3.50 for PPC-E, 4.78 for PPC-F, and 5.03 for PPC-G (severe periodontal disease). Periodontal disease was significantly associated with cardioembolic (hazard ratio, 2.6; 95% confidence interval, 1.2–5.6) and thrombotic (hazard ratio, 2.2; 95% confidence interval, 1.3–3.8) stroke subtypes. Regular dental care utilization was associated with lower adjusted stroke risk (hazard ratio, 0.77; 95% confidence interval, 0.63–0.94).
Conclusions—We confirm an independent association between periodontal disease and incident stroke risk, particularly cardioembolic and thrombotic stroke subtype. Further, we report that regular dental care utilization may lower this risk for stroke
http://stroke.ahajournals.org/content/early/2018/01/12/STROKEAHA.117.018990
..classified into 7 periodontal profile classes (PPCs) The 7 levels of PPC showed a trend toward an increased stroke risk (χ2 trend P<0.0001); the incidence rate for ischemic stroke/1000-person years was 1.29 for PPC-A (health), 2.82 for PPC-B, 4.80 for PPC-C, 3.81 for PPC-D, 3.50 for PPC-E, 4.78 for PPC-F, and 5.03 for PPC-G (severe periodontal disease). Periodontal disease was significantly associated with cardioembolic (hazard ratio, 2.6; 95% confidence interval, 1.2–5.6) and thrombotic (hazard ratio, 2.2; 95% confidence interval, 1.3–3.8) stroke subtypes. Regular dental care utilization was associated with lower adjusted stroke risk (hazard ratio, 0.77; 95% confidence interval, 0.63–0.94).
Conclusions—We confirm an independent association between periodontal disease and incident stroke risk, particularly cardioembolic and thrombotic stroke subtype. Further, we report that regular dental care utilization may lower this risk for stroke
#Periodontal Disease Assessed Using Clinical Dental Measurements and #Cancer Risk in the ARIC Study
https://academic.oup.com/jnci/advance-article-abstract/doi/10.1093/jnci/djx278/4804361?redirectedFrom=fulltext
An increased risk of total cancer (hazard ratio HR = 1.24, 95% confidence interval CI = 1.07 to 1.44, Ptrend = .004) was observed for severe periodontitis (>30% of sites with attachment loss >3 mm) compared with no/mild periodontitis (<10% of sites with attachment loss >3 mm), adjusting for smoking and other factors. Strong associations were observed for lung cancer (HR = 2.33, 95% CI = 1.51 to 3.60, Ptrend < .001), and elevated risks were noted for colorectal cancer for severe periodontitis, which were significant among never smokers (HR = 2.12, 95% CI = 1.00 to 4.47). Associations were generally weaker, or not apparent among black participants, except for lung and colorectal cancers, where associations were similar by race. No associations were observed for breast, prostate, or hematopoietic and lymphatic cancer risk.
Conclusions
This study provides additional evidence that cancer risk, especially for lung and colorectal cancer, is elevated in individuals with periodontitis. Additional research is needed to understand cancer site–specific and racial differences in findings
https://academic.oup.com/jnci/advance-article-abstract/doi/10.1093/jnci/djx278/4804361?redirectedFrom=fulltext
An increased risk of total cancer (hazard ratio HR = 1.24, 95% confidence interval CI = 1.07 to 1.44, Ptrend = .004) was observed for severe periodontitis (>30% of sites with attachment loss >3 mm) compared with no/mild periodontitis (<10% of sites with attachment loss >3 mm), adjusting for smoking and other factors. Strong associations were observed for lung cancer (HR = 2.33, 95% CI = 1.51 to 3.60, Ptrend < .001), and elevated risks were noted for colorectal cancer for severe periodontitis, which were significant among never smokers (HR = 2.12, 95% CI = 1.00 to 4.47). Associations were generally weaker, or not apparent among black participants, except for lung and colorectal cancers, where associations were similar by race. No associations were observed for breast, prostate, or hematopoietic and lymphatic cancer risk.
Conclusions
This study provides additional evidence that cancer risk, especially for lung and colorectal cancer, is elevated in individuals with periodontitis. Additional research is needed to understand cancer site–specific and racial differences in findings
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Poor Oral Health and Blood #Pressure Control Among US Hypertensive Adults
https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.118.11528
#Periodontal disease is a chronic inflammatory disorder of the tissues surrounding the teeth, with evidence of systemic effects. Some studies showed the benefit of periodontal therapy on blood pressure (BP), but the impact of periodontitis on BP control is unknown.
.. Systolic BP means and odds ratios for uncontrolled BP according to the presence and severity of periodontitis were calculated using progressively adjusted models. Among treated hypertensive adults, mean systolic BP was about 2.3 to 3 mm Hg higher in the presence of periodontitis (P<0.0001).
Periodontitis was associated with unsuccessful antihypertensive treatment after multiple adjustments, with higher odds by disease severity.
A good periodontal health is associated with better systolic BP profile during antihypertensive therapy by about 2.3 to 3 mm Hg and with lower odds of antihypertensive treatment failure. Dedicated studies are needed to test the impact of periodontal therapy on BP and the long-term effects on cardiovascular outcomes of this complementary approach to systemic health
Poor Oral Health and Blood #Pressure Control Among US Hypertensive Adults
https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.118.11528
#Periodontal disease is a chronic inflammatory disorder of the tissues surrounding the teeth, with evidence of systemic effects. Some studies showed the benefit of periodontal therapy on blood pressure (BP), but the impact of periodontitis on BP control is unknown.
.. Systolic BP means and odds ratios for uncontrolled BP according to the presence and severity of periodontitis were calculated using progressively adjusted models. Among treated hypertensive adults, mean systolic BP was about 2.3 to 3 mm Hg higher in the presence of periodontitis (P<0.0001).
Periodontitis was associated with unsuccessful antihypertensive treatment after multiple adjustments, with higher odds by disease severity.
A good periodontal health is associated with better systolic BP profile during antihypertensive therapy by about 2.3 to 3 mm Hg and with lower odds of antihypertensive treatment failure. Dedicated studies are needed to test the impact of periodontal therapy on BP and the long-term effects on cardiovascular outcomes of this complementary approach to systemic health
#Periodontal Inflammation Primes the Systemic Innate #Immune Response
https://2medical.news/2020/10/28/periodontal-inflammation-primes-the-systemic-innate-immune-response/
The presence of periodontal diseases (PDs) often strongly correlates with other severe chronic inflammatory conditions, including cardiovascular disease, diabetes, and arthritis. However, the mechanisms through which these diseases interact are unclear. In PD, tissue and bone destruction in the mouth is driven by elevated recruitment of polymorphonuclear neutrophils (PMNs), which are primed and recruited from the circulation to sites of inflammation. We predicted that systemic …
https://2medical.news/2020/10/28/periodontal-inflammation-primes-the-systemic-innate-immune-response/
The presence of periodontal diseases (PDs) often strongly correlates with other severe chronic inflammatory conditions, including cardiovascular disease, diabetes, and arthritis. However, the mechanisms through which these diseases interact are unclear. In PD, tissue and bone destruction in the mouth is driven by elevated recruitment of polymorphonuclear neutrophils (PMNs), which are primed and recruited from the circulation to sites of inflammation. We predicted that systemic …
Effects of #mouthwash on #periodontal pathogens and glycemic control in patients with type 2 #diabetes mellitus
https://2medical.news/2024/02/23/effects-of-mouthwash-on-periodontal-pathogens-and-glycemic-control-in-patients-with-type-2-diabetes-mellitus/
https://2medical.news/2024/02/23/effects-of-mouthwash-on-periodontal-pathogens-and-glycemic-control-in-patients-with-type-2-diabetes-mellitus/
2Medical.News
Effects of #mouthwash on #periodontal pathogens and glycemic control in patients with type 2 #diabetes mellitus
Periodontitis is known to be associated with type 2 diabetes mellitus (T2DM), and gargling with mouthwash is known to reduce the incidence of periodontitis by inhibiting periodontal pathogens. Howe…