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Lamictal (#lamotrigine ): Drug Safety Communication - Serious Immune System #Reaction
https://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm605628.htm
The immune system reaction, called hemophagocytic lymphohistiocytosis (HLH), causes an uncontrolled response by the immune system. HLH typically presents as a persistent fever, usually greater than 101°F, and it can lead to severe problems with blood cells and organs throughout the body such as the liver, kidneys, and lungs
Advise patients to seek immediate medical attention if they experience symptoms of HLH during lamotrigine treatment. A diagnosis of HLH can be established if a patient has at least five of the following eight signs or symptoms:
fever and rash
enlarged spleen
cytopenias
elevated levels of triglycerides or low blood levels of fibrinogen
high levels of blood ferritin
hemophagocytosis identified through bone marrow, spleen, or lymph node biopsy
decreased or absent Natural Killer (NK) Cell activity
elevated blood levels of CD25 showing prolonged immune cell activation
Lamictal (#lamotrigine ): Drug Safety Communication - Serious Immune System #Reaction
https://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm605628.htm
The immune system reaction, called hemophagocytic lymphohistiocytosis (HLH), causes an uncontrolled response by the immune system. HLH typically presents as a persistent fever, usually greater than 101°F, and it can lead to severe problems with blood cells and organs throughout the body such as the liver, kidneys, and lungs
Advise patients to seek immediate medical attention if they experience symptoms of HLH during lamotrigine treatment. A diagnosis of HLH can be established if a patient has at least five of the following eight signs or symptoms:
fever and rash
enlarged spleen
cytopenias
elevated levels of triglycerides or low blood levels of fibrinogen
high levels of blood ferritin
hemophagocytosis identified through bone marrow, spleen, or lymph node biopsy
decreased or absent Natural Killer (NK) Cell activity
elevated blood levels of CD25 showing prolonged immune cell activation
Lamictal (#lamotrigine): Drug Safety Communication – Studies Show Increased Risk of #Heart Rhythm Problems in Patients with Heart Disease
https://2medical.news/2021/04/03/lamictal-lamotrigine-drug-safety-communication-studies-show-increased-risk-of-heart-rhythm-problems-in-patients-with-heart-disease/
Lamotrigine is used alone or with other medicines to treat seizures in patients 2 years and older. It may also be used as maintenance treatment in patients with the mental health condition bipolar disorder to help delay the occurrence of mood episodes such as depression, mania, or hypomania. RECOMMENDATIONS: Patients should not stop taking your medicine without first talking to your prescriber because stopping lamotrigine …
https://2medical.news/2021/04/03/lamictal-lamotrigine-drug-safety-communication-studies-show-increased-risk-of-heart-rhythm-problems-in-patients-with-heart-disease/
Lamotrigine is used alone or with other medicines to treat seizures in patients 2 years and older. It may also be used as maintenance treatment in patients with the mental health condition bipolar disorder to help delay the occurrence of mood episodes such as depression, mania, or hypomania. RECOMMENDATIONS: Patients should not stop taking your medicine without first talking to your prescriber because stopping lamotrigine …