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Aldo Lorenzetti M.D, Internal Medicine & Hepatology, Milano - SIMEDET Delegate
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A Time Frame for Testing Negative for SARS- #COV2 in People with #Obesity
https://2medical.news/2020/11/07/a-time-frame-for-testing-negative-for-sars-cov2-in-people-with-obesity/

Objective: Obesity is a major risk factor for becoming seriously ill with the 2019 novel coronavirus (COVID-19). One difficulty faced by clinicians and by patients is the unknown time frame of hospitalization until discharge of symptomatic patients. Methods: We followed 34 patients with laboratory-confirmed COVID-19 infection who recovered fromthe infection. All diagnoses were given using semi-quantitative RT-PCR on nasopharyngeal swabs. Envelope protein gene (E), RNA-dependent …
#Avocado Consumption Alters Gastrointestinal #Bacteria Abundance and Microbial Metabolite Concentrations among Adults with Overweight or #Obesity: A Randomized Controlled Trial
https://2medical.news/2021/01/02/avocado-consumption-alters-gastrointestinal-bacteria-abundance-and-microbial-metabolite-concentrations-among-adults-with-overweight-or-obesity-a-randomized-controlled-trial/

Avocados are rich in dietary fiber and monounsaturated fatty acids (MUFAs), nutrients that have been independently connected to metabolic health benefits and the gastrointestinal microbiota. Objectives We aimed to evaluate the impact of avocado consumption on the gastrointestinal microbiota and microbial metabolites, secondary outcomes of the Persea americana for Total Health (PATH) study, and conduct exploratory analyses to assess relations between the fecal microbiota, fecal …
#Adipose saturation reduces #lipotoxic systemic inflammation and explains the #obesity paradox
https://2medical.news/2021/02/05/adipose-saturation-reduces-lipotoxic-systemic-inflammation-and-explains-the-obesity-paradox/

Obesity sometimes seems protective in disease. This obesity paradox is predominantly described in reports from the Western Hemisphere during acute illnesses. Since adipose triglyceride composition corresponds to long-term dietary patterns, we performed a meta-analysis modeling the effect of obesity on severity of acute pancreatitis, in the context of dietary patterns of the countries from which the studies originated. Increased severity was noted in leaner populations …
Once-Weekly #Semaglutide in Adults with Overweight or #Obesity
https://2medical.news/2021/02/13/once-weekly-semaglutide-in-adults-with-overweight-or-obesity/

Obesity is a global health challenge with few pharmacologic options. Whether adults with obesity can achieve weight loss with once-weekly semaglutide at a dose of 2.4 mg as an adjunct to lifestyle intervention has not been confirmed. METHODS In this double-blind trial, we enrolled 1961 adults with a body-mass index (the weight in kilograms divided by the square of the height in meters) of 30 …
Association of #Gastric Bypass Surgery With Risk of Developing #Diabetic #Retinopathy Among Patients With #Obesity and Type 2 Diabetes in Sweden
https://2medical.news/2021/02/21/association-of-gastric-bypass-surgery-with-risk-of-developing-diabetic-retinopathy-among-patients-with-obesity-and-type-2-diabetes-in-sweden/

Knowledge of the incidence and progression of diabetic retinopathy (DR) after gastric bypass surgery (GBP) in patients with obesity and diabetes could guide the management of these patients. Objective To investigate the incidence of diabetic ocular complications in patients with type 2 diabetes after GBP compared with the incidence of diabetic ocular complications in a matched cohort of patients with obesity and diabetes who have …
Self- Monitoring via Digital Health in #Weight Loss Interventions: A Systematic Review Among Adults with Overweight or #Obesity
https://2medical.news/2021/03/01/self-monitoring-via-digital-health-in-weight-loss-interventions-a-systematic-review-among-adults-with-overweight-or-obesity/

Objective: Self- monitoring is a core component of behavioral obesity treatment, but it is unknown how digital health has been used for self- monitoring, what engagement rates are achieved in these interven-tions, and how self- monitoring and weight loss are related. Methods: This systematic review examined digital self- monitoring in behavioral weight loss interventions among adults with overweight or obesity. Six databases (PubMed, Embase, Scopus, …
Association between #obesity with pattern and length of #menstrual cycle: The role of metabolic and hormonal markers
https://2medical.news/2021/03/03/association-between-obesity-with-pattern-and-length-of-menstrual-cycle-the-role-of-metabolic-and-hormonal-markers/

To evaluate in a sample of Chilean adult women, the association between adiposity markers with pattern and length of the menstrual cycle, assessing the influence of metabolic markers and hormones in this relationship. Study design We conducted a cross-sectional study involving 401 premenopausal women belonging to the DERCAM study (Determinants of Breast Cancer Risk) from Santiago, Chile. The menstrual cycle pattern was defined as regular …
#Semaglutide 2·4 mg once a week in adults with #overweight or #obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial
https://2medical.news/2021/03/24/semaglutide-2%C2%B74-mg-once-a-week-in-adults-with-overweight-or-obesity-and-type-2-diabetes-step-2-a-randomised-double-blind-double-dummy-placebo-controlled-phase-3-trial/

Background This trial assessed the efficacy and safety of the GLP-1 analogue once a week subcutaneous semaglutide 2·4 mg versus semaglutide 1·0 mg (the dose approved for diabetes treatment) and placebo for weight management in adults with overweight or obesity, and type 2 diabetes. Methods This double-blind, double-dummy, phase 3, superiority study enrolled adults with a body-mass index of at least 27 kg/m2 and glycated …
#Obesity and Responsiveness to #Food Marketing Before and After #Bariatric Surgery
https://2medical.news/2021/04/09/obesity-and-responsiveness-to-food-marketing-before-and-after-bariatric-surgery/

Although food marketing is often accused of increasing population obesity, the relationship between individual responsiveness to marketing and obesity has yet to be established: Are people with obesity more responsive to food marketing and, if so, is it a stable trait or can it be reversed by bariatric surgery? We studied the responses to three common marketing tactics that frame foods and portions as healthier …