!!
The Microbial Metabolite #Butyrate Stimulates #Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression

https://www.cell.com/immunity/fulltext/S1074-7613(18)30478-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318304783%3Fshowall%3Dtrue

Highlights
• Treatment with the probiotic Lactobacillus rhamnosus GG (LGG) increases bone mass in mice by stimulating the production of butyrate

•LGG or butyrate expands the pool of Treg cells in the gut and the bone marrow

•Treg cells upregulate the expression of osteogenic Wnt ligand Wnt10b by CD8+ T cell

•Wnt10b stimulates bone formation by activating Wnt signaling in osteoblasts