Association of Age at Onset of #Menopause and Time Since Onset of Menopause With Cardiovascular Outcomes, Intermediate Vascular Traits, and All-Cause #Mortality
A Systematic Review and Meta-analysis
http://cardiology.jamanetwork.com/mobile/article.aspx?articleid=2551981
Conclusions and Relevance The findings of this review indicate a higher risk of CHD, CVD mortality, and overall mortality in women who experience premature or early-onset menopause.
A Systematic Review and Meta-analysis
http://cardiology.jamanetwork.com/mobile/article.aspx?articleid=2551981
Conclusions and Relevance The findings of this review indicate a higher risk of CHD, CVD mortality, and overall mortality in women who experience premature or early-onset menopause.
Jamanetwork
Association of Age at and Time Since Menopause With Cardiovascular Outcomes
This meta-analysis systematically reviews and meta-analyzes studies evaluating the effect of age at onset of menopause and time since onset of menopause on intermediate cardiovascular disease end points, cardiovascular disease outcomes, and all-cause mortality.
Age at natural #menopause and risk of type 2 #diabetes: a prospective cohort study
https://link.springer.com/article/10.1007/s00125-017-4346-8
In this study, we aimed to examine the association between age at natural menopause and risk of type 2 diabetes, and to assess whether this association is independent of potential mediators. During a median follow-up of 9.2 years, we identified 348 individuals with incident type 2 diabetes. After adjustment for confounders, HRs for type 2 diabetes were 3.7 (95% CI 1.8, 7.5), 2.4 (95% CI 1.3, 4.3) and 1.60 (95% CI 1.0, 2.8) for women with premature, early and normal menopause, respectively, relative to those with late menopause (ptrend <0.001). The HR for type 2 diabetes per 1 year older at menopause was 0.96 (95% CI 0.94, 0.98). Further adjustment for BMI, glycaemic traits, metabolic risk factors, C-reactive protein, endogenous sex hormone levels or shared genetic factors did not affect this association. Conclusions/interpretation
Early onset of natural menopause is an independent marker for type 2 diabetes in postmenopausal women
https://link.springer.com/article/10.1007/s00125-017-4346-8
In this study, we aimed to examine the association between age at natural menopause and risk of type 2 diabetes, and to assess whether this association is independent of potential mediators. During a median follow-up of 9.2 years, we identified 348 individuals with incident type 2 diabetes. After adjustment for confounders, HRs for type 2 diabetes were 3.7 (95% CI 1.8, 7.5), 2.4 (95% CI 1.3, 4.3) and 1.60 (95% CI 1.0, 2.8) for women with premature, early and normal menopause, respectively, relative to those with late menopause (ptrend <0.001). The HR for type 2 diabetes per 1 year older at menopause was 0.96 (95% CI 0.94, 0.98). Further adjustment for BMI, glycaemic traits, metabolic risk factors, C-reactive protein, endogenous sex hormone levels or shared genetic factors did not affect this association. Conclusions/interpretation
Early onset of natural menopause is an independent marker for type 2 diabetes in postmenopausal women
SpringerLink
Age at natural menopause and risk of type 2 diabetes: a prospective co
In this study, we aimed to examine the association between age at natural menopause and risk of type 2 diabetes, and to assess whether this association is independent of potential mediators.
We includ
We includ
Painful #sex and bladder problems take toll on women's libido during #menopause
New study provides added insights as to why women become less sexually active as they age
https://www.eurekalert.org/pub_releases/2017-10/tnam-psa100617.php
As women age, sexual activity typically declines. But that doesn't necessarily mean they are no longer interested in sex. The problem for many is physical. A new study demonstrates the impact on sexual activity of postmenopausal women as a result of vulvovaginal atrophy and lower urinary tract problems.
In recent years the medical community adopted the terminology "genitourinary syndrome of menopause" (GSM) to more accurately refer to the collective vaginal and bladder problems that affect many women during menopause. In simpler terms, GSM includes symptoms of painful sex as a result of a thinning of the vaginal walls, along with bladder problems that can lead to urine leakage during sexual activity, as well as during other unpredictable times. As part of this new study, researchers assessed the impact of these symptoms on a woman's ability to be sexually active and enjoy the sexual experience
New study provides added insights as to why women become less sexually active as they age
https://www.eurekalert.org/pub_releases/2017-10/tnam-psa100617.php
As women age, sexual activity typically declines. But that doesn't necessarily mean they are no longer interested in sex. The problem for many is physical. A new study demonstrates the impact on sexual activity of postmenopausal women as a result of vulvovaginal atrophy and lower urinary tract problems.
In recent years the medical community adopted the terminology "genitourinary syndrome of menopause" (GSM) to more accurately refer to the collective vaginal and bladder problems that affect many women during menopause. In simpler terms, GSM includes symptoms of painful sex as a result of a thinning of the vaginal walls, along with bladder problems that can lead to urine leakage during sexual activity, as well as during other unpredictable times. As part of this new study, researchers assessed the impact of these symptoms on a woman's ability to be sexually active and enjoy the sexual experience
EurekAlert!
Painful sex and bladder problems take toll on women's libido during menopause
As women age, sexual activity typically declines. But that doesn't necessarily mean they are no longer interested in sex. The problem for many is physical. A new study demonstrates the impact on sexual activity of postmenopausal women as a result of vulvovaginal…
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Age at #menopause and lifetime #cognition
Findings from a British birth cohort study
http://n.neurology.org/content/early/2018/04/11/WNL.0000000000005486
Verbal memory increased with later age at natural menopause (0.17 words per year, 95% confidence interval CI: 0.07–0.27, p = 0.001); an association remained, albeit attenuated, after full adjustment (0.09, 95% CI: 0.02–0.17, p = 0.013). Verbal memory also increased with later age at surgical menopause (0.16, 95% CI: 0.06–0.27, p = 0.002), but this association was fully attenuated after adjustment. Search speed was not associated with age at menopause.
Conclusion Our findings suggest lifelong hormonal processes, not just short-term fluctuations during the menopause transition, may be associated with verbal memory, consistent with evidence from a variety of neurobiological studies; mechanisms are likely to involve estrogen receptor β function. Further follow-up is required to assess fully the clinical significance of these associations
Age at #menopause and lifetime #cognition
Findings from a British birth cohort study
http://n.neurology.org/content/early/2018/04/11/WNL.0000000000005486
Verbal memory increased with later age at natural menopause (0.17 words per year, 95% confidence interval CI: 0.07–0.27, p = 0.001); an association remained, albeit attenuated, after full adjustment (0.09, 95% CI: 0.02–0.17, p = 0.013). Verbal memory also increased with later age at surgical menopause (0.16, 95% CI: 0.06–0.27, p = 0.002), but this association was fully attenuated after adjustment. Search speed was not associated with age at menopause.
Conclusion Our findings suggest lifelong hormonal processes, not just short-term fluctuations during the menopause transition, may be associated with verbal memory, consistent with evidence from a variety of neurobiological studies; mechanisms are likely to involve estrogen receptor β function. Further follow-up is required to assess fully the clinical significance of these associations
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Association of age at #menopause and type 2 #diabetes: A systematic review and dose-response meta-analysis of cohort studies
https://www.primary-care-diabetes.com/article/S1751-9918(18)30406-6/fulltext?mobileUi=0
We identified 6 studies for the meta-analysis (267,284 women and 19,654 cases of T2DM). The pooled RR was 0.64 (95% CI 0.44–0.94) comparing the latest with the earliest category of age at menopause. The risk of T2DM was reduced by 10% (RR = 0.90, 95% CI, 0.84–0.98) with each 5-year increment in age at menopause. We found an inverse linear association between age at menopause and T2DM.
Conclusions
Our results suggest that later age at menopause was associated with lower risk of T2DM.
Association of age at #menopause and type 2 #diabetes: A systematic review and dose-response meta-analysis of cohort studies
https://www.primary-care-diabetes.com/article/S1751-9918(18)30406-6/fulltext?mobileUi=0
We identified 6 studies for the meta-analysis (267,284 women and 19,654 cases of T2DM). The pooled RR was 0.64 (95% CI 0.44–0.94) comparing the latest with the earliest category of age at menopause. The risk of T2DM was reduced by 10% (RR = 0.90, 95% CI, 0.84–0.98) with each 5-year increment in age at menopause. We found an inverse linear association between age at menopause and T2DM.
Conclusions
Our results suggest that later age at menopause was associated with lower risk of T2DM.
Early onset of #menopause is associated with increased peripheral #atherosclerotic plaque volume and progression
Cardiovascular disease (CVD) is the leading cause of death in western countries. One risk factor unique to women is the menopausal status. The aim of this study was to analyse the influence of the onset of menopause (MP) on the extent and progression of atherosclerotic plaque volume (PV).
..110 consecutive postmenopausal women (mean age 65.5) were included. Females with an earlier onset of MP (<45 years) had a significantly higher PV than those with an intermediate (45–52 years) or later onset of menopause (>52 years), irrespective of other CVRF (244 mm³ vs. 193 mm³ vs. 73 mm³, respectively, p = 0.023). In addition, women with an earlier onset of MP had a higher PV progression compared to women with an intermediate or late onset (40 mm³ vs. 35 mm³ vs. 8.5 mm³; p = 0.002, respectively). Moreover, these results were confirmed in multivariate regression, where only onset of MP (OR 0.88; 95%CI 0.81–0.96; p = 0.004) and age (OR 1.06; 95%CI 1.08–1.13; p = 0.025) were significant predictors for a higher atherosclerotic progression.
Conclusions
An earlier onset of MP was associated with an increase in atherosclerotic PV and accelerated progression, independent of other CVRF.
https://bit.ly/2ulisw6
Cardiovascular disease (CVD) is the leading cause of death in western countries. One risk factor unique to women is the menopausal status. The aim of this study was to analyse the influence of the onset of menopause (MP) on the extent and progression of atherosclerotic plaque volume (PV).
..110 consecutive postmenopausal women (mean age 65.5) were included. Females with an earlier onset of MP (<45 years) had a significantly higher PV than those with an intermediate (45–52 years) or later onset of menopause (>52 years), irrespective of other CVRF (244 mm³ vs. 193 mm³ vs. 73 mm³, respectively, p = 0.023). In addition, women with an earlier onset of MP had a higher PV progression compared to women with an intermediate or late onset (40 mm³ vs. 35 mm³ vs. 8.5 mm³; p = 0.002, respectively). Moreover, these results were confirmed in multivariate regression, where only onset of MP (OR 0.88; 95%CI 0.81–0.96; p = 0.004) and age (OR 1.06; 95%CI 1.08–1.13; p = 0.025) were significant predictors for a higher atherosclerotic progression.
Conclusions
An earlier onset of MP was associated with an increase in atherosclerotic PV and accelerated progression, independent of other CVRF.
https://bit.ly/2ulisw6
Mitochondrial and redox dysfunction in post-#menopause as risk factor of neurodegenerative disease: a pilot study testing the role of a validated Japanese functional food.
https://2medical.news/2020/04/30/mitochondrial-and-redox-dysfunction-in-post-menopause-as-risk-factor-of-neurodegenerative-disease-a-pilot-study-testing-the-role-of-a-validated-japanese-functional-food/
During the menopause women may experience increased oxidative stress and decreased antioxidant capacity and, together with the decline of neurosteroids, this represents a risk factor for Alzheimer’s disease. The aim of the present study was to test a functional food (FPP-ORI, Osato Research Institute, Gifu, Japan) on redox and mitochondrial efficiency in post-menopausal women. The study population consisting of 69 untreated post-menopausal women were given …
https://2medical.news/2020/04/30/mitochondrial-and-redox-dysfunction-in-post-menopause-as-risk-factor-of-neurodegenerative-disease-a-pilot-study-testing-the-role-of-a-validated-japanese-functional-food/
During the menopause women may experience increased oxidative stress and decreased antioxidant capacity and, together with the decline of neurosteroids, this represents a risk factor for Alzheimer’s disease. The aim of the present study was to test a functional food (FPP-ORI, Osato Research Institute, Gifu, Japan) on redox and mitochondrial efficiency in post-menopausal women. The study population consisting of 69 untreated post-menopausal women were given …
#Menopause Transition and #Cardiovascular Disease Risk: Implications for Timing of Early Prevention: A Scientific Statement From the American Heart Association
https://2medical.news/2020/12/06/menopause-transition-and-cardiovascular-disease-risk-implications-for-timing-of-early-prevention-a-scientific-statement-from-the-american-heart-association/
Cardiovascular disease (CVD) is the leading cause of death in women, who have a notable increase in the risk for this disease after menopause and typically develop coronary heart disease several years later than men. This observation led to the hypothesis that the menopause transition (MT) contributes to the increase in coronary heart disease risk. Over the past 20 years, longitudinal studies of women traversing …
https://2medical.news/2020/12/06/menopause-transition-and-cardiovascular-disease-risk-implications-for-timing-of-early-prevention-a-scientific-statement-from-the-american-heart-association/
Cardiovascular disease (CVD) is the leading cause of death in women, who have a notable increase in the risk for this disease after menopause and typically develop coronary heart disease several years later than men. This observation led to the hypothesis that the menopause transition (MT) contributes to the increase in coronary heart disease risk. Over the past 20 years, longitudinal studies of women traversing …