Hi, here are our latest posts on Medium. We would be glad to read your comments and thoughts.
https://medium.com/@teterin_71247/how-can-you-earn-while-checking-your-health-db4f0fe2dc2b
https://medium.com/@teterin_71247/do-you-know-how-to-live-long-137710e848ed
https://medium.com/@teterin_71247/how-to-prolong-life-with-ai-insights-928a316b1a61
https://medium.com/@teterin_71247/how-ai-models-are-transforming-evidence-based-predictions-1724f566f501

https://interestingengineering.com/health/first-quantum-cancer-therapy?

Hey everyone. For APOE-ε4 carriers (especially homozygotes) and their physicians, note a potential breakthrough paper.

Background: homotaurine (tramiprosate) was trialed as an Alzheimer's drug, was looking good but failed to meet its Phase III endpoints. Then the data was re-analyzed, and a gene dose–dependent effect was seen: it helped APOE-ε4 carriers: heterozygotes a bit; homozygotes a lot. The assumption was that it was clearing amyloid, and APOE-ε4 carriers have more amyloid, hence the gene-dose effect. But a new paper – a brilliant piece of analytic chemistry – suggests that homotaurine is an apoE4 structure corrector, which, if true, would be a game changer: it could mean that all APOE-ε4–associated pathology would be reduced with a simple supplement. (Just need to figure out dosing.)

https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-023-00620-9

Homotaurine seems to induce an apoE3-like conformation in apoE4.

Corrective gene therapy is the ultimate solution for APOE-ε4 carriers, but for now, taking this simple supplement (it's available without a prescription) could really help, especially for homozygotes. It appears to be very safe. (Some people experience nausea and even vomiting though.)

Alzheon has modified homotaurine to improve the PK and tolerability and is running trials in APOE-ε4 homozygotes. Provisional results have been announced and it looks good so far.

https://alzheon.com/alzheon-reports-industry-leading-biomarker-brain-preservation-and-clinical-benefits-following-24-months-of-treatment-in-phase-2-trial-of-oral-alz-801-valiltramiprosate-in-patients-with-early-alzhei/

https://alzheon.com/pipeline/alzheon-alz-801/

Alzheon will be presenting in Boston next month. I will try to go:
https://www.ctad-alzheimer.com/

Cryotherapy Benefits

Decreases Muscle Soreness after exercise [1,2,3]
Helps Alleviate Chronic Pain - Especially in Rheumatic Arthritis and Fybromyalgia [6]
WBC mimics exercise, in its ability to induce a pulsatile expression of myokines (IL-6, irisin) opening possibilities for treating Obesity and Type 2 Diabetes - [2]
Metabolism up-regulation [2]
positive influence on inflammatory mediators, [2}
Increased antioxidant capacity, [2]
Improved autonomic nervous system function [2]
Does not blunt Exercise Effectiveness [4]
Improves depression [5]
^1 - https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD008262.pub2/full
^2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411446/
^3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956737/
^4 https://www.frontiersin.org/articles/10.3389/fspor.2022.834386/full
^5 https://www.sciencedirect.com/science/article/pii/S0965229921001242#bib29
^6 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119547/

Cold swimming benefits 0-5 C
Benefits - Lowers blood pressure
Decrease in triglycerides
Increase in insulin sensitivity
Decrease in norepinephrine
Increase in cortisol
Antidepressant effect
Immune system
Increase in leucocytes
Increase in monocytes
Fewer infections (40% lower Upper Resp Tract Infections)

Cold-Water Swimming Benefits and Risks
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730683/

Good afternoon!

My girlfriend has 2 relatives here in Dar es Salaam (Tanzania)

1. Older brother is 29 years old. From the age of 22 he began to suffer from some kind of mental disorder. I think it is autism

2. Cousin is 4 years old. His mother (the girl's sister) died during childbirth. And the boy most likely has cerebral palsy. But it is not exactly

Can you help find recommended specialists and centers to work with such people? Remotely from anywhere or/and in Africa / Tanzania?

The family did not have the opportunity to take care of the children's health, as it is common not only in Africa. I would like to help them

Thanks for any help and advice

We organized the first Rally for Longevity in Madrid.... working towards #TheDeathOfDeath, enjoy LIFE 🖖🖖🖖 https://youtu.be/2YW0jj00UMU

https://www.businesswire.com/news/home/20231018615272/en/Physics-Powered-GenAI-Biotech-Gero-Raises-6M-to-Find-Root-Causes-of-Aging-and-Age-Related-Diseases

Team, our competitors doing fundraising on the same topics we are working on

Opinions?

https://nuchido.com/blogs/news/how-is-nuchido-time-different-from-nad-precursors

Dr Church super optimistic and mentions BioViva https://www.youtube.com/watch?v=ON8vxUInQYA