Tomorrow) stay tuned for a video recording after Longevity Summit Africa

Thanks to AfroLongevity Summit.

23-24 August 2023. 26 Degrees South Hotel, Johannesburg, South Africa

Video recording from Summit is coming!

Stay tuned

Interesting!

https://www.fightaging.org/archives/2023/08/young-plasma-from-pigs-reduces-epigenetic-age-in-old-rats/

October 2nd (Online) LLMs for Life Sciences Course (free): https://us06web.zoom.us/meeting/register/tZUud-uvqTkjE9Zn3X5EruRlL-X7FuFIAwHW#/registration

Longevity Gene Transfer is done ✔️ 🙌

https://scitechdaily.com/new-breakthrough-paves-the-way-for-extending-human-lifespan-scientists-successfully-transfer-longevity-gene/

Please join our Virtual Reality Ending Aging Forum!

This event will showcase the newest breakthroughs in rejuvenation biotechnologies happening at the SENS Research Foundation’s Research Center in Mountain View, CA, as well as the research funded at extramural labs.
The Forum will be hosted virtually through Meetaverse, a state-of-the-art Virtual Reality platform.
You won't need to download any special software or wear a VR headset to walk around in your avatar, enjoy the scientific presentations and visit the student poster booths in the Conference Hall.
You will also be able to connect with our scientists, team members, and other guests, through one-on-one or group conversations, watch videos and animations placed in the Expo Room, and much more.
Join us September 21st and 22nd at 9 am -1 pm, Pacific Time for a fun and educational experience, and come ready to network and meet donors who support longevity science, activists, and like-minded people who care about a future free of age-related disease.

https://www.sens.org/endingagingforum-2023/

Hi, here are our latest posts on Medium. We would be glad to read your comments and thoughts.
https://medium.com/@teterin_71247/how-can-you-earn-while-checking-your-health-db4f0fe2dc2b
https://medium.com/@teterin_71247/do-you-know-how-to-live-long-137710e848ed
https://medium.com/@teterin_71247/how-to-prolong-life-with-ai-insights-928a316b1a61
https://medium.com/@teterin_71247/how-ai-models-are-transforming-evidence-based-predictions-1724f566f501

https://interestingengineering.com/health/first-quantum-cancer-therapy?

Hey everyone. For APOE-ε4 carriers (especially homozygotes) and their physicians, note a potential breakthrough paper.

Background: homotaurine (tramiprosate) was trialed as an Alzheimer's drug, was looking good but failed to meet its Phase III endpoints. Then the data was re-analyzed, and a gene dose–dependent effect was seen: it helped APOE-ε4 carriers: heterozygotes a bit; homozygotes a lot. The assumption was that it was clearing amyloid, and APOE-ε4 carriers have more amyloid, hence the gene-dose effect. But a new paper – a brilliant piece of analytic chemistry – suggests that homotaurine is an apoE4 structure corrector, which, if true, would be a game changer: it could mean that all APOE-ε4–associated pathology would be reduced with a simple supplement. (Just need to figure out dosing.)

https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-023-00620-9

Homotaurine seems to induce an apoE3-like conformation in apoE4.

Corrective gene therapy is the ultimate solution for APOE-ε4 carriers, but for now, taking this simple supplement (it's available without a prescription) could really help, especially for homozygotes. It appears to be very safe. (Some people experience nausea and even vomiting though.)

Alzheon has modified homotaurine to improve the PK and tolerability and is running trials in APOE-ε4 homozygotes. Provisional results have been announced and it looks good so far.

https://alzheon.com/alzheon-reports-industry-leading-biomarker-brain-preservation-and-clinical-benefits-following-24-months-of-treatment-in-phase-2-trial-of-oral-alz-801-valiltramiprosate-in-patients-with-early-alzhei/

https://alzheon.com/pipeline/alzheon-alz-801/

Alzheon will be presenting in Boston next month. I will try to go:
https://www.ctad-alzheimer.com/