GSTM1: The glutathione S-transferase mu 1 (GSTM1) gene results in the production of an enzyme that aids in the detoxification of a number of substances. Increased longevity and better health outcomes have been linked to certain GSTM1 gene variants. Source: “GSTM1”: http://www.cancerindex.org/geneweb/GSTM1.htm#:~:text=GSTM1%20is%20a%20glutathione%20S,a%20range%20of%20different%20cancers.
HSPA1A/HSPA1B: These genes are members of the heat shock protein (HSP) family and are involved in the regulation of protein quality and the response of cells to stress. Longevity and enhanced stress tolerance have been related to variations in the HSPA1A and HSPA1B genes. Source: “Anti-Inflammatory Heat Shock Protein 70 Genes are Positively Associated with Human Survival”: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631775/
PINK1: PTEN-induced putative kinase 1 (PINK1) gene mutations have been linked to Parkinson's disease. A longer lifespan and resistance to cellular stress have also been associated with certain PINK1 gene variants. Source: “PINK1 signaling in mitochondrial homeostasis and in aging (Review)”: https://www.spandidos-publications.com/10.3892/ijmm.2016.2827
BPIFB4: The innate immune system is regulated by the gene BPI fold-containing family B member 4 (BPIFB4). Alterations in the BPIFB4 gene have been linked to a longer life expectancy and a lower chance of developing age-related disorders. Source: “The longevity-associated BPIFB4 gene supports cardiac function and vascularization in aging cardiomyopathy”: https://pubmed.ncbi.nlm.nih.gov/36635236/
TP53: The TP53 gene produces the tumour protein p53, which is essential for DNA repair, controlling the cell cycle, and causing apoptosis. Longevity and a lower chance of developing cancer have been associated with certain TP53 gene variants. Source: “The Regulation of Aging and Longevity”: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135645/
Should they all be applied at once? Or maybe it depends on the individual?
It is uncommon to employ the genes linked to long life as a single package or treatment. Instead, they behave as possible predictors of characteristics that could support lifespan. These genes can have a complicated and variable impact on longevity depending on the person, their genetic composition, and their environment.
It's critical to remember that genetics only accounts for a small portion of lifespan. Diet, exercise, stress management, and environmental influences are all important lifestyle aspects.
It is also difficult to separate the influence of specific genes in a complex characteristic like lifespan since the interaction between genes and environment is a dynamic process.
The majority of the present knowledge on genes linked to long life is derived from observational research and genetic association studies, which offer correlations rather than causes.
As a result, it is not advised to utilise genetic data for lifespan as a firm prescription or treatment strategy. Instead, it is generally agreed that the ideal method for maintaining lifespan and wellbeing is a complete approach that includes a healthy lifestyle, frequent medical checkups, and proactive treatment of risk factors.
Evidence based articles and links:
“Genetics of extreme human longevity to guide drug discovery for healthy ageing”: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912776/
“The Genetics of Aging”: https://www.annualreviews.org/doi/10.1146/annurev.genom.2.1.435
HSPA1A/HSPA1B: These genes are members of the heat shock protein (HSP) family and are involved in the regulation of protein quality and the response of cells to stress. Longevity and enhanced stress tolerance have been related to variations in the HSPA1A and HSPA1B genes. Source: “Anti-Inflammatory Heat Shock Protein 70 Genes are Positively Associated with Human Survival”: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631775/
PINK1: PTEN-induced putative kinase 1 (PINK1) gene mutations have been linked to Parkinson's disease. A longer lifespan and resistance to cellular stress have also been associated with certain PINK1 gene variants. Source: “PINK1 signaling in mitochondrial homeostasis and in aging (Review)”: https://www.spandidos-publications.com/10.3892/ijmm.2016.2827
BPIFB4: The innate immune system is regulated by the gene BPI fold-containing family B member 4 (BPIFB4). Alterations in the BPIFB4 gene have been linked to a longer life expectancy and a lower chance of developing age-related disorders. Source: “The longevity-associated BPIFB4 gene supports cardiac function and vascularization in aging cardiomyopathy”: https://pubmed.ncbi.nlm.nih.gov/36635236/
TP53: The TP53 gene produces the tumour protein p53, which is essential for DNA repair, controlling the cell cycle, and causing apoptosis. Longevity and a lower chance of developing cancer have been associated with certain TP53 gene variants. Source: “The Regulation of Aging and Longevity”: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135645/
Should they all be applied at once? Or maybe it depends on the individual?
It is uncommon to employ the genes linked to long life as a single package or treatment. Instead, they behave as possible predictors of characteristics that could support lifespan. These genes can have a complicated and variable impact on longevity depending on the person, their genetic composition, and their environment.
It's critical to remember that genetics only accounts for a small portion of lifespan. Diet, exercise, stress management, and environmental influences are all important lifestyle aspects.
It is also difficult to separate the influence of specific genes in a complex characteristic like lifespan since the interaction between genes and environment is a dynamic process.
The majority of the present knowledge on genes linked to long life is derived from observational research and genetic association studies, which offer correlations rather than causes.
As a result, it is not advised to utilise genetic data for lifespan as a firm prescription or treatment strategy. Instead, it is generally agreed that the ideal method for maintaining lifespan and wellbeing is a complete approach that includes a healthy lifestyle, frequent medical checkups, and proactive treatment of risk factors.
Evidence based articles and links:
“Genetics of extreme human longevity to guide drug discovery for healthy ageing”: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912776/
“The Genetics of Aging”: https://www.annualreviews.org/doi/10.1146/annurev.genom.2.1.435
https://www.newscientist.com/article/mg25834382-900-ageing-is-inevitable-but-we-may-soon-treat-it-like-any-other-disease/
#longevity
#longevityintime
#antiaging
#invest
#longevity
#longevityintime
#antiaging
#invest
New Scientist
Ageing is inevitable, but we may soon treat it like any other disease
Getting older is a fact of life, but there are promising signs that we may be able to intervene to slow – and possibly even stop – the molecular processes that lead to numerous age-related conditions
More news regarding quercetin + Dasatinib.
https://www.lifespan.io/news/benefits-of-dasatinib-and-quercetin-treatment-in-monkeys/
https://www.lifespan.io/news/benefits-of-dasatinib-and-quercetin-treatment-in-monkeys/
www.lifespan.io
Benefits of Dasatinib and Quercetin Treatment in Monkeys
In one of the first studies of its kind, the popular senolytic combination, administered systematically for six months, produced several health benefits in these animals. Some effects were augmented by caloric restriction [1]. Coup de grâce for […]
Have you heard about fascinating Bryan Johnson who is reversing aging, for 2M$ per year with the help of 30 doctors, incl. brilliant Oliver Zolman who advised us for some time?
https://youtu.be/aj3bQa6gcOg
We do the same, but with AI and almost for free.
The main part - it’s personalized, because what is good for Bryan can be harmful for you!
Interested? Join our Longevity AI powered Guide
https://youtu.be/aj3bQa6gcOg
We do the same, but with AI and almost for free.
The main part - it’s personalized, because what is good for Bryan can be harmful for you!
Interested? Join our Longevity AI powered Guide
YouTube
This man ages backwards?
Bryan Johnson spends $2 million to become 18 again. And you won't believe how he is doing it!
Thank you Bryan Johnson for sharing your life with us!
And thank you to Lorena @sustentofila for telling this story!
Video credit: @BryanJohnson YouTube Channel…
Thank you Bryan Johnson for sharing your life with us!
And thank you to Lorena @sustentofila for telling this story!
Video credit: @BryanJohnson YouTube Channel…
ChatGPT Reviews in Longevity, Medicine and Science
ChatGPT is designed to understand and generate human-like text based on the patterns it has learned from a diverse range of internet sources. It can provide information, explanations, and engage in conversations on various subjects, including longevity, medicine, and science. However, it's important to note that while ChatGPT strives to provide accurate and up-to-date information, it may not always have access to the most recent research or breakthroughs in these fields since chatgpt training data only goes up until September 2021. Therefore, it's always a good idea to verify information from primary and authoritative sources.
Regarding longevity, ChatGPT can discuss general concepts and ideas related to extending human lifespan, such as the role of genetics, lifestyle factors, and advancements in medical technology. It can provide insights into the current understanding of aging processes, potential interventions, and ongoing research in the field. However, for specific medical advice or detailed discussions on cutting-edge longevity research, it's best to consult experts or refer to scientific literature.
In terms of medicine, ChatGPT can provide general information about various medical conditions, treatment options, and common practices. It can help explain medical terms, offer insights into symptoms, and discuss broad aspects of different diseases. However, it's essential to remember that ChatGPT is not a substitute for professional medical advice, diagnosis, or treatment. For personalized medical guidance or information, it's always advisable to consult qualified healthcare professionals.
Regarding science topics, ChatGPT can engage in discussions about a wide range of scientific disciplines, theories, and discoveries. It can provide explanations of scientific concepts, discuss historical scientific breakthroughs, and offer insights into various scientific fields. However, for specific scientific inquiries or highly specialized knowledge, it's recommended to consult subject-matter experts or refer to scientific literature.
It's worth noting that since ChatGPT knowledge cutoff is in September 2021, there may have been significant advancements or new discoveries in longevity, medicine, and science since then. So, it's always a good idea to supplement the information provided by ChatGPT with the most up-to-date and reliable sources available.
Overall, ChatGPT can be a useful tool to facilitate discussions, provide general information, and offer insights into various topics, including longevity, medicine, and science. However, it's important to exercise critical thinking, validate information from reliable sources, and consult domain experts for specific and authoritative knowledge in these fields
ChatGPT is designed to understand and generate human-like text based on the patterns it has learned from a diverse range of internet sources. It can provide information, explanations, and engage in conversations on various subjects, including longevity, medicine, and science. However, it's important to note that while ChatGPT strives to provide accurate and up-to-date information, it may not always have access to the most recent research or breakthroughs in these fields since chatgpt training data only goes up until September 2021. Therefore, it's always a good idea to verify information from primary and authoritative sources.
Regarding longevity, ChatGPT can discuss general concepts and ideas related to extending human lifespan, such as the role of genetics, lifestyle factors, and advancements in medical technology. It can provide insights into the current understanding of aging processes, potential interventions, and ongoing research in the field. However, for specific medical advice or detailed discussions on cutting-edge longevity research, it's best to consult experts or refer to scientific literature.
In terms of medicine, ChatGPT can provide general information about various medical conditions, treatment options, and common practices. It can help explain medical terms, offer insights into symptoms, and discuss broad aspects of different diseases. However, it's essential to remember that ChatGPT is not a substitute for professional medical advice, diagnosis, or treatment. For personalized medical guidance or information, it's always advisable to consult qualified healthcare professionals.
Regarding science topics, ChatGPT can engage in discussions about a wide range of scientific disciplines, theories, and discoveries. It can provide explanations of scientific concepts, discuss historical scientific breakthroughs, and offer insights into various scientific fields. However, for specific scientific inquiries or highly specialized knowledge, it's recommended to consult subject-matter experts or refer to scientific literature.
It's worth noting that since ChatGPT knowledge cutoff is in September 2021, there may have been significant advancements or new discoveries in longevity, medicine, and science since then. So, it's always a good idea to supplement the information provided by ChatGPT with the most up-to-date and reliable sources available.
Overall, ChatGPT can be a useful tool to facilitate discussions, provide general information, and offer insights into various topics, including longevity, medicine, and science. However, it's important to exercise critical thinking, validate information from reliable sources, and consult domain experts for specific and authoritative knowledge in these fields
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Mike Lustgarten, PhD - Telomere Length Test #6: Correlations With Diet https://youtu.be/gWeht1QdpLc
YouTube
Telomere Length Test #6: Correlations With Diet
Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD
Discount Links:
Telomere Length, Epigenetic Testing: https://trudiagnostic.com/?irclickid=U-s3Ii2r7xyIU-LSYLyQdQ62UkAVXBWtRVKJUM0&irgwc=1
Use Code: CONQUERAGING
NAD+ Quantification: http…
Discount Links:
Telomere Length, Epigenetic Testing: https://trudiagnostic.com/?irclickid=U-s3Ii2r7xyIU-LSYLyQdQ62UkAVXBWtRVKJUM0&irgwc=1
Use Code: CONQUERAGING
NAD+ Quantification: http…
Very interesting, new in vivo aspects of the mitochondrial metabolisms role for cell fate and differentiation, transdifferentiation potential, cancer stem cells https://phys.org/news/2023-06-uncovers-clues-cell-plasticity.html
phys.org
Study uncovers new clues about the process of cell plasticity
Researchers have long thought that once a cell starts down its path of differentiation, growing into a skin cell or a liver cell or a neuron, that path could not be changed.
The long-awaited video of Gero CEO Peter Fedichev's speech at Zuzalu can now be viewed at: https://zuzalu.streameth.org/session/869 . For more detailed information about Gero's latest findings on the fundamentals of aging, check out the article "Humans Can Stop—But Not Fully Reverse—Aging" in Popular Mechanics: https://www.popularmechanics.com/science/health/a43510158/humans-can-stop-aging-but-not-reverse-it-study/
The next round of interesting public talks between Peter Fedichev and Aubrey De Grey on general prospects and Gero's plans on stopping aging, as well as about the limits of age reversal , is expected to take place in Dublin https://longevitysummitdublin.com/.
The world is changing, so stay tuned for updates. You can follow Gero.ai on
https://www.facebook.com/geroscience
www.linkedin.com/company/4994380
https://twitter.com/GeroMaxim
https://www.crunchbase.com/organization/gero/signals_and_news
The next round of interesting public talks between Peter Fedichev and Aubrey De Grey on general prospects and Gero's plans on stopping aging, as well as about the limits of age reversal , is expected to take place in Dublin https://longevitysummitdublin.com/.
The world is changing, so stay tuned for updates. You can follow Gero.ai on
https://www.facebook.com/geroscience
www.linkedin.com/company/4994380
https://twitter.com/GeroMaxim
https://www.crunchbase.com/organization/gero/signals_and_news
Zuzalu city
Aging clocks, entropy, and the limits of age-reversal · Zuzalu city
Zuzalu is a first-of-its-kind pop-up city community in Montenegro.
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Interesting research analyzes the impact of transhumanism on psychology.
Published: June 16, 2022
A researcher from the Autonomous University of Chile seeks to investigate what he considers "unprecedented" changes that the implementation of transhumanist proposals would mean for society from a psychological perspective and how psychology could foresee and anticipate such a radical scenario with the necessary ethical imperatives.
Transhumanism is a school of thought based on the idea that the human species should evolve, using all possible technological means, both those currently available and those yet to be developed. The goal is to enhance and improve all human capabilities, whether it be in terms of intelligence and other cognitive abilities.
"It seeks to improve human nature, even from its conception, surpassing what it calls its limitations and prolonging existence through reason," adds Manuel Pérez Ayala, researcher at the School of Psychology of the Autonomous University of Chile, Talca campus.
He adds, "From this perspective, it refers to humanity, as it is known today, as transitioning through an intermediate stage, which they identify as transhuman symbolized by human + until reaching posthuman symbolized by human ++."
This ideology proposes that technologies for human enhancement be widely available; that individuals have the right to transform their own bodies as they wish; that parents have access to the right to choose which technologies to use when having children, among others.
For the researcher, "studying and delving into the various dimensions of transhumanism means applying reason, science, and technology to understand, confront, and even overcome various human phenomena such as diseases and disabilities, as well as other social issues such as information distribution, capital, and wealth, to name a few, aiming to optimize lifestyle and quality of life."
The applications would be practically limitless: from the development of artificial intelligence through cognitive science; new forms of political-legal governance; to the suppression and even eradication of pathologies, also leading to a new conception of the human spiritual experience, to name a few.
According to Manuel Pérez Ayala, since the center of study and research for psychology is human thinking and action, "the impact of transhumanism in both areas is unprecedented and of unknown radicality because humanity has never faced such a profound change as the one that looms ahead."
Therefore, he considers it important to discuss transhumanism in advance to avoid deepening any kind of gaps (social, cultural, economic, among others) in humanity.
In this context, he proposes that this line of research has the challenge of measuring the impact it will have on each area of psychology: "perhaps the specialties that will be most affected will be experimental, cognitive, and clinical, to name three with broad range and scope. That is why the first step is to start questioning and proposing an attitude of understanding to anticipate the inevitable controversies that lie ahead."
Pérez Ayala, M. (2022). Is it premature to talk about the impact and ethical implications of transhumanism for Psychology? Revista Ethika+, (5), 87–99. https://doi.org/10.5354/2452-6037.2022.66272
Published: June 16, 2022
A researcher from the Autonomous University of Chile seeks to investigate what he considers "unprecedented" changes that the implementation of transhumanist proposals would mean for society from a psychological perspective and how psychology could foresee and anticipate such a radical scenario with the necessary ethical imperatives.
Transhumanism is a school of thought based on the idea that the human species should evolve, using all possible technological means, both those currently available and those yet to be developed. The goal is to enhance and improve all human capabilities, whether it be in terms of intelligence and other cognitive abilities.
"It seeks to improve human nature, even from its conception, surpassing what it calls its limitations and prolonging existence through reason," adds Manuel Pérez Ayala, researcher at the School of Psychology of the Autonomous University of Chile, Talca campus.
He adds, "From this perspective, it refers to humanity, as it is known today, as transitioning through an intermediate stage, which they identify as transhuman symbolized by human + until reaching posthuman symbolized by human ++."
This ideology proposes that technologies for human enhancement be widely available; that individuals have the right to transform their own bodies as they wish; that parents have access to the right to choose which technologies to use when having children, among others.
For the researcher, "studying and delving into the various dimensions of transhumanism means applying reason, science, and technology to understand, confront, and even overcome various human phenomena such as diseases and disabilities, as well as other social issues such as information distribution, capital, and wealth, to name a few, aiming to optimize lifestyle and quality of life."
The applications would be practically limitless: from the development of artificial intelligence through cognitive science; new forms of political-legal governance; to the suppression and even eradication of pathologies, also leading to a new conception of the human spiritual experience, to name a few.
According to Manuel Pérez Ayala, since the center of study and research for psychology is human thinking and action, "the impact of transhumanism in both areas is unprecedented and of unknown radicality because humanity has never faced such a profound change as the one that looms ahead."
Therefore, he considers it important to discuss transhumanism in advance to avoid deepening any kind of gaps (social, cultural, economic, among others) in humanity.
In this context, he proposes that this line of research has the challenge of measuring the impact it will have on each area of psychology: "perhaps the specialties that will be most affected will be experimental, cognitive, and clinical, to name three with broad range and scope. That is why the first step is to start questioning and proposing an attitude of understanding to anticipate the inevitable controversies that lie ahead."
Pérez Ayala, M. (2022). Is it premature to talk about the impact and ethical implications of transhumanism for Psychology? Revista Ethika+, (5), 87–99. https://doi.org/10.5354/2452-6037.2022.66272
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