Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality
Overview:
• Individuals age at different rates for a variety of reasons, including different levels of exposure to risk factors and intrinsic variance in biological processes.
• Here, we provide a technique for calculating the biological age—or rate of ageing—of 18-year-old adults by utilising 18 clinical indicators from 9 organ systems.
• To identify which biomarkers at age 26 predict biological age at age 38, we use cross- sectional data from the Dunedin cohort (N=954).
• According to our research, physiological dysregulation is a defining feature of aging, and older biological ages are associated with an increased risk of chronic illness, decreased physical function, cognitive decline, and early mortality.
• Notably, the pace of ageing may be detected in mid-life, indicating that early adulthood would be the best time to begin anti-aging therapies.
• We come to the conclusion that accounting for ageing as the time-dependent accumulation of various dysfunctions recapitulates patterns of global health deterioration and offers a useful framework for assessing treatments aimed at extending healthspan.
• The goal of the study is to use 18 clinical indicators from 9 organ systems to gauge the biological age of 18-year-old individuals.
• The Dunedin cohort cross-sectional data (N=954) is used by the researchers to identify the biomarkers that, at age 26, accurately predict biological age at age 38.
• They discover that physiological dysregulation is a defining feature of ageing and that older biological ages are associated with an increased risk of chronic illness, decreased physical function, cognitive decline, and early mortality.
• Given that the pace of ageing may be seen in midlife, measures to delay ageing would need to begin in early adulthood.
Key Findings:
• The rate of aging, or biological age, in 18-year-old individuals was assessed by the researchers using 18 clinical indicators from 9 organ systems.
• The characteristic of ageing is physiological dysregulation, and older biological ages are associated with an increased risk of chronic illness, decreased physical function, cognitive decline, and early mortality.

• Given that the pace of ageing may be seen in midlife, measures to delay ageing would need to begin in early adulthood.
• By quantifying ageing as the time-dependent accumulation of various dysfunctions, the study offers a means to evaluate treatments to increase healthspan.
The biomarkers implemented in each organ system are listed below: Hematopoietic System:
• Mean corpuscular volume (MCV)
• Red blood cell distribution width (RDW)
Cardiovascular System:
• Systolic blood pressure (SBP) • Mean arterial pressure (MAP) • Pulse pressure (PP)
• Heart rate (HR)
Respiratory System:
• Forced expiratory volume in 1 second (FEV1) • Forced vital capacity (FVC)
Renal System:
• Creatinine clearance (CrCl)
Metabolic System:
• Hemoglobin A1c (HbA1c)
• Total cholesterol (Tchol)
• High-density lipoprotein (HDL) cholesterol • Low-density lipoprotein (LDL) cholesterol • Triglycerides (TG)
Liver System:
• Alanine transaminase (ALT) • Alkaline phosphatase (ALP)
Immune System:
• C-reactive protein (CRP)
Cognitive System:
• Logical memory delayed recall

Musculoskeletal System:
• Grip strength.
Additional Details:
• The Dunedin Multidisciplinary Health and Development research, a longitudinal research that followed 1,037 people from birth to age 45, provided the data for the study.
• To quantify biological age, which is defined as the time-dependent accumulation of dysfunctions in various physiological systems, the researchers employed 18 clinical indicators from 9 organ systems.
• Age 26 was used to measure the biomarkers, and age 38 was used to determine biological age.
• According to the study, there is significant individual variance in the rate of aging, and this variation is caused by both environmental and hereditary variables.

• Higher biological ages are associated with greater risk of chronic illnesses, decreased physical function, cognitive decline, and early mortality. Physiological dysregulation is a characteristic of ageing.
• Given that the pace of ageing may be seen in midlife, measures to delay ageing would need to begin in early adulthood.
• By quantifying ageing as the time-dependent accumulation of various dysfunctions, the study also offers a viable way for evaluating treatments to increase healthspan.
• The study's overall conclusion emphasises the significance of comprehending the variety of ageing across many organ systems in order to create successful therapies to increase healthspan.
Evidence based articles and links:
The efficacy of vaccines against COVID-19:
• Efficacy of the BNT162b2 mRNA COVID-19 vaccine in a nationwide vaccination setting: A cohort study in Israel (https://pubmed.ncbi.nlm.nih.gov/33626250/)
• Real-world effectiveness of COVID-19 mRNA vaccines against hospitalizations and deaths in United States (https://www.medrxiv.org/content/ 10.1101/2021.04.21.21255873v1#:~:text=mRNA%20vaccines%20were%2096%25%2 0(95,when%20participants%20were%20fully%20vaccinated.)

The impact of diet on health outcomes:
• Mediterranean diet and cardiovascular disease: a systematic review and meta-analysis of observational studies (https://pubmed.ncbi.nlm.nih.gov/29177567/)
• Systematic review of the impact of a plant-based diet on prostate cancer incidence and outcomes (https://pubmed.ncbi.nlm.nih.gov/35790788/ #:~:text=Observational%20studies%20demonstrated%20either%20a,environmental% 20sustainability%20and%20animal%20welfare.)
The effectiveness of cognitive-behavioral therapy for mental health:
• Cognitive-behavioral therapy for anxiety disorders: an update on the empirical evidence (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610618/)
• Cognitive behaviour therapy for depression in primary care: systematic review and meta-analysis (https://pubmed.ncbi.nlm.nih.gov/30688184/)
The effects of physical exercise on health outcomes:
• Physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke events: systematic review and dose-response meta- analysis for the Global Burden of Disease Study 2013 (https:/ pubmed.ncbi.nlm.nih.gov/27510511/)
• Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases (https://pubmed.ncbi.nlm.nih.gov/26606383/)

More on aging and other health and lifestyle related topics

In 2022 expenditures on warfare were 2,2 trillion USD, 55% spent by US, China & Russia

Meanwhile how much spent on longevity ?

Complete idiots…

Walking and its benefits
• Walking is a fantastic type of exercise with many positive health effects. The daily suggested quantity of walking might vary depending on your age, degree of fitness, and overall health.
• The Centers for Disease Control and Prevention (CDC) advises individuals to strive for 150 minutes or more of moderate-intensity aerobic activity per week, which can include brisk walking.
• The amount of kilometres per day that are deemed healthy in terms of distance also relies on personal circumstances.
• According to a research in the British Journal of Sports Medicine, walking at least 10,000 steps per day has several positive health effects, including enhanced insulin sensitivity, reduced blood pressure, and lower body mass index (BMI).
• The amount of steps or kilometres might, however, fluctuate based on a variety of circumstances, so it's crucial to choose an activity level that you can maintain and like.
Who are the people restricted from walking?
• It may be necessary to reduce or restrict one's walking for those who have specific medical issues or injuries.
• For instance, persons with heart or lung issues may need to avoid walking in harsh temperatures or at high elevations, while those with severe arthritis or joint discomfort may need to avoid high-impact activities like walking or jogging.
Evidence based articles and links?
Benefits of Walking:
• "Physical Activity Guidelines for Americans, 2nd edition" by the U.S. Department of Health and Human Services: https://health.gov/sites/default/files/2019-09/ Physical_Activity_Guidelines_2nd_edition.pdf
• "Effect of Brisk Walking on Health-Related Physical Fitness Balance and Life Satisfaction Among the Elderly: A Systematic Review”: https://www.frontiersin.org/ articles/10.3389/fpubh.2021.829367/full
Distance to Walk:
• "Daily step goal of 10,000 steps: a literature review": https://pubmed.ncbi.nlm.nih.gov/ 17716553/
• "How many steps/day are enough? Preliminary pedometer indices for public health":
https://pubmed.ncbi.nlm.nih.gov/14715035/

Restrictions on Walking:
"Arthritis Foundation Exercise Program (AFEP): https://www.cdc.gov/arthritis/ interventions/programs/afep.htm
"Exercise and asthma: an overview: https://www.ncbi.nlm.nih.gov/pmc/articles/ PMC4653278/

Alzheimer’s

Questions:
1. How it can be transmitted
2. What are the precautions can be taken
3. What is incubation period
4. What are therapeutic measures can be taken during incubation period if not sure 5. Are the quick test kits are accurate?

Answers:
1. It has been suggested that Aβ is transmissible within the brains of AD patient. This raises the critical question of whether AD is also transmissible from person to person. Three years ago, researchers led by John Collinge and Sebastian Brandner found that abundant Aβ deposition was present in the brain parenchyma and blood vessels of patients who died of iatrogenic CJD (iCJD) following childhood treatment with human cadaveric pituitary-derived growth hormone (c-hGH) that contained both prions and Aβ [3], suggesting the possibility that Aβ seeds could propagate from one person to another.
2.
● The strongest evidence, in Dr. Marshall's opinion, is that regular exercise can either stop Alzheimer's disease in its tracks or at least delay its course in those who already have symptoms. "The recommended is 30 minutes of three to four days a week of fairly strenuous aerobic activity."
● Consume a Mediterranean diet. "It has been demonstrated that doing this can slow the onset or stop Alzheimer's disease. According to a recent study, those who find it difficult to fully stick to a new diet may nevertheless benefit from at least partially following it "Dr. Marshall adds. Fresh fruits and vegetables, whole grains, olive oil, nuts, legumes, fish, poultry, eggs, and dairy products in moderation, red wine in moderation, and red meat in moderation are all included in the diet.
● Get enough sleep.

Incubation period is the time elapsed between exposure to a pathogenic organism, a
chemical, or radiation, and when symptoms and signs are first apparent
3.
Age is the dominant risk factor in Alzheimer’s disease. Recently it was suggested by two groups
that accelerated biological aging is associated with cognitive decline,
4.
● Get enough sleep
Longitudinal cohort studies are
necessary to determine whether biological aging is the cause, a contributor or a confounder of
Alzheimer’s disease
● Drugs can improve some memory problems and reduce some behavioral symptoms of
Alzheimer’s disease
5.blood test very, very accurately predicts who's got Alzheimer's disease in their brain, including
people who seem to be normal

References
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864016/
[2] https://www.health.harvard.edu/alzheimers-and-dementia/what-can-you-do-to-avoid-alzheimers- disease
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819914/
By:NoraYehia

We are live in Google Play with new version of our app for tracking early stages of diseases

Please test it

https://play.google.com/store/apps/details?id=com.longevity.diseaseTracker

Dear members of Longevity InTime Telegram’s Open Channel, we search for different sources of promotion of Longevity InTime products and made this link in Shop for app promo:

https://longevityintime.shop/products/disease-tracker-pro

Its free to buy. Please review all texts in Shop and try to buy (for free) this app and make the whole customer journey and share the feedback. It will help to improve this particular product

Please also comment on other 3 products in this link:

https://longevityintime.shop/

More products to come.


Thanks

#feedback

*April 7, 2023*
*Rapamycin, the only drug that has been consistently demonstrated to increase mammalian longevity. An update*
https://www.sciencedirect.com/science/article/pii/S0531556523000876

Join LongevityCoin Twitter:

https://twitter.com/LongevityCoin

And Discord server:

https://discord.gg/7s98nFKa

The airdrop is coming soon

Dr David Sinclair’s Basic SUPPLEMENT PROTOCOL 2023 Latest Update
https://youtu.be/_yCGV-Z3vhg

In #aging research, the line between science and pseudoscience is blurry!

On this episode of GEN Live sponsored by @SartoriusGlobal we’ll parse fact from fiction and explore what the science says about the possibility of lifespan extension. Register now: ow.ly/PqL350O6PzY

Leonid Peshkin (Harvard Medical
School)

Here's a cached version: https://web.archive.org/web/20230515124810/https://nordictimes.com/science/researchers-may-have-found-the-cause-of-parkinsons-disease/

Link to the publication the article is based upon:
https://www.frontiersin.org/articles/10.3389/fcimb.2023.1181315/full

Rapamycin reduces the total amount of senescent cells

Rather than simply modifying senescent cells present in the tissue, rapamycin treatment either reduces the number of cells entering senescence or increases the clearance of senescent cells
https://gethealthspan.com/blog/articles/inhibiting-skin-senescence-with-topical-rapamycin-sirolimus-for-anti-aging-skincare/40o2ogqdwaekuxak96h3iy/