Good podcast on dogs as a model organism for studying aging

https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy50cmFuc2lzdG9yLmZtL3RhbGtpbmctYmlvdGVjaA/episode/YzQ5NzQ1MzMtMjY2MC00NmI5LWIyOWMtZDQyYTc0NWMxNmVj?ep=14

This adds to the above paper and explains the redox signalling element.

https://www.frontiersin.org/articles/10.3389/fimmu.2021.636072/full

Dear Longevity members!

As some of you might know, that there is a humanitarian crisis going on in Russia, because of the assault on Ukraine.

So many Russians fight to leave a country prior potential lockdown.

Longevity InTime is doing its impact to try to save at least few asylum seekers lives and can offer few seats on Emirates flight on 27-th of September from Sankt Petersburg through Dubai to the most destinations. Please direct me for details

Take a good care!

*Sept 19, 2022*
*Alzheimer’s might not be primarily a brain disease. A new theory suggests it’s an autoimmune condition.*
https://theconversation.com/alzheimers-might-not-be-primarily-a-brain-disease-a-new-theory-suggests-its-an-autoimmune-condition-189047

A harsh critique from Charles Brenner to David Sinclair...
*Sep 26, 2022*
*A Science-Based Review of the World's Best-Selling Book on Aging*
https://www.sciencedirect.com/science/article/abs/pii/S0167494322002126

This isn't a scientific article as such, but it well written and documented.
*Sept 29, 2022*
*Could epigenetic reprogramming reverse aging?*
https://leaps.org/fountain-of-youth/particle-3

Just a bit off our topics, but maybe not necessarily off … support Peace & Longevity:

https://collaborateforpeace.com/?fbclid=IwAR2g_EL4rz4qnTRUljLOobhSSKXXjkqpWUmc-m6DNhwnV02LPfPELBU6W4g

Check out the latest digital organs designs generated by proprietary AI.

AI Digital Organs NFTs are coming soon:

https://www.instagram.com/reel/CjgYARKoN3g/?igshid=MDE2OWE1N2Q=

Parrots live a long time. There is a scientific article on this topic. It turned out that parrots have:

1. Bigger brain relative to body size

2. High density of neurons in the forebrain

3. Developed cognitive abilities, including the use of tools

4. Complex social organization

5. Vocalization acquired through cultural transmission

6. Ability to solve problems collaboratively

7. Long periods of development and education

8. Exceptional lifespan, especially given their high metabolism.

In 2018, the genome of one of the longest-lived parrots, the blue-fronted Amazon (Amazona aestiva), was sequenced. Dimensions - 30 cm in length and 400 g of weight. Estimated maximum life expectancy is more than 90 years, accurately recorded today is 66 years.

A comparative analysis was carried out to search for common genes in this species of parrot and a number of long-lived birds. They were compared with not long-lived birds. Scientists have described several common pathways for them, potentially linked to longevity.

First of all, this is an increased activity of the TERT enzyme (telomerase reverse transcriptase). This year Church also took it as a target for mice in his work.

But, as noted, TERT activity can be dangerous due to the degeneration of tissues. To offset these possible effects from TERT, long-lived birds (and the parrot) have a number of active pathways:

“Despite protection against cell aging, the risk of high TERT activity lies in the increased rate of uncontrolled proliferation and tumor formation.

Emphasizing the importance of balancing these processes, we found that several genes under selective pressure in long-lived birds (BUB1B, BUB3, KIF4A, KIF1BP, CCNE1) are associated with control cell proliferation and tumor proliferation.

Specific mechanisms include regulation of spindle assembly during cell division by mitotic control proteins, control of chromosome integrity during mitosis by a microtubule-based motor protein, and control of cell cycle and tumor suppression mechanisms.

Based on these findings, we hypothesize that a balanced co-evolution of telomerase activity and cell cycle regulation pathways may represent a mechanism to prevent an increase in cancer incidence during the evolution of longevity in birds."

What else. Long-lived birds were expected to have increased activity in pathways associated with DNA repair and genomic stability, mitochondrial function and reduced oxidative stress, and RNA function.

"Overall, our results suggest that changes in telomerase, DNA repair, cell cycle progression, RNA splicing and processing, and oxidative stress pathways may be critical to extend lifespan in birds."

In addition to longevity, groups of genes associated with good cognitive abilities in parrots are described separately.

Misha Batin

Evidence based article:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393663/

Implant instead of radiation therapy? New promising method of fighting cancer

Pancreatic cancer is usually diagnosed in the later stages, when there is little chance of salvation. A pancreatic tumor is one of the most deadly types of cancer.

Scientists from Duke University have presented a new therapy that completely destroyed the tumor of the pancreas in almost all laboratory rodents: 80% were completely cured, in 20% the tumor was significantly reduced. The new technology is a radioactive implant made from biocompatible materials: the radioactive element iodine-131 is placed inside a biodegradable gel, which simultaneously prevents its leakage into the body.

The results provide hope for promising treatments for other types of cancer: perhaps implants will work better than radiation therapy. But not in the near future: there is still a lot of research work ahead, which, in fact, has only just begun.