We need to translate Russian news post into natural English, format per rules.

We need a short headline under 90 chars, first line no markdown, then blank line, then body split into short paragraphs (2-3 sentences each), separated by blank lines.

Wrap few genuinely important facts — key numbers, percentages, drug/company/gene names, dates — in double asterisks. At most 4-5 per post, never a whole sentence.

Wrap study/journal citations and publication references in single underscores (e.g., Nature Aging, July 2026).

We need to preserve all facts, numbers, names, citations exactly. No commentary.

We need to identify key facts: date: 4 сентября (September 4) in Science Advances. Also mention 2018 year. Also mention drug: doxorubicin (доксорубицин). Genes: Sod2, ACO2, SLC25A1, ACLY, H3K27Ac, H3K9Ac. Also mention mice. Possibly numbers: not many numbers. Could include "4 September" as date. Also maybe "Science Advances". Also "2018". Also "doxorubicin". Also "Sod2". Also "ACO2". Also "SLC25A1". Also "ACLY". Also "H3K27Ac". Also "H3K9Ac". That's many; we need to limit to 4-5 double asterisks. Choose most important: date, drug, gene names maybe. But we need to wrap key numbers, percentages, drug/company/gene names, dates. So we can wrap each gene name? That would be many. We need to be selective: at most 4-5 per post. So choose maybe: September 4, Science Advances, doxorubicin, Sod2, ACO2? That's 5. Or we could include SLC25A1, ACLY, but limit.

We need to wrap study/journal citations in single underscores: e.g., Science Advances, September 4? Actually citation: "4 сентября в Science Advances вышла работа о мышах". So we can wrap the journal name and date in single underscores: Science Advances, September 4. Also mention 2018 work: maybe 2018 study? But we can just wrap the citation.

We need to ensure we don't wrap whole sentences. So we need to embed double asterisks around specific facts within sentences, not whole sentence.

We need to produce short paragraphs 2-3 sentences each.

Let's craft translation.

First line headline: maybe "Mitochondrial stress in embryos confers lasting heart protection in mice". Count characters: Let's count: "Mitochondrial stress in embryos confers lasting heart protection in mice". That's 66 characters approx. Under 90.

Now blank line.

Now body paragraphs.

Paragraph 1: talk about study published September 4 in Science Advances; embryos had transient oxidative stress via Sod2 suppression; after birth Sod2 restored; adult hearts partially protected from doxorubicin damage.

We need to embed double asterisks for key facts: maybe September 4, Science Advances, doxorubicin, Sod2. That's 4.

We need to embed single underscores for citation: maybe Science Advances, September 4 (but we already used double asterisks for date and journal; we need to follow rule: wrap study/journal citations and publication references in single underscores. So the citation should be underscores, not double asterisks. So we need to decide: either we use double asterisks for key numbers/drug/gene names, and single underscores for citations. So we cannot double asterisk the journal name if we also need to underscore it. So we need to choose: either we underscore the citation, and double asterisk other facts like drug, gene names, date maybe. But date is part of citation; maybe we can underscore the whole citation Science Advances, September 4 and double asterisk other facts like doxorubicin, Sod2, ACO2, SLC25A1? That's 4 double asterisks.

Let's do: double asterisks for doxorubicin, Sod2, ACO2, SLC25A1 (or ACLY). Choose 4.

Single underscores for citation: Science Advances, September 4.

Also maybe we need to underscore the 2018 work: could be 2018 study but not necessary.

We need to ensure we don't overdo double asterisks.…

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Spatial-ATAC-Hi-C maps DNA folding and accessibility in tissue slices

In Nature Methods published September 1, researchers presented Spatial-ATAC-Hi-C, a method that simultaneously measures DNA contacts and chromatin accessibility at each point of a tissue slice. DNA in the nucleus is packed into chromatin that forms loops, bringing distant regulatory elements near genes; open chromatin is accessible to regulatory proteins, and assigning coordinates to these two dimensions is essential because neighboring cells can belong to different types and follow distinct gene programs.

The tissue is fixed on a glass slide, DNA fragments that interacted in nuclei are ligated, and two perpendicular series of microchannels with barcodes—50 horizontal and 50 vertical channels—create up to 2,500 points; each point occupies a 50 × 50 µm square and typically contains 3–21 cells. After sequencing, barcodes return both DNA contacts and accessible regulatory regions to each point.

Validation against independent Hi‑C and ATAC‑seq on adjacent mouse brain slices showed the protocol preserves both signals, and the map distinguished chromatin loops characteristic of different neuron types and brain areas. In astrocytoma and glioblastoma samples Spatial-ATAC-Hi-C detected copy‑number changes and structural rearrangements of genomic fragments, which matched whole‑genome sequencing of neighboring slices.

In one glioblastoma specimen spatially segregated groups of points with distinct copy‑number profiles displayed concordant contact and accessibility maps. In aged tissue the approach can test whether changes in DNA accessibility, long‑range genome contacts, and cellular composition coincide within the same zones.

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Ray Kurzweil Joins Subsense as Advisor on Brain‑Nanoparticle Interface

On September 3, Ray Kurzweil became a product and vision advisor to the California startup Subsense. The company says it will introduce two types of nanoparticles through the nose to interface with the brain, using a wearable device to read and stimulate neuronal activity.

According to Subsense, plasmonic particles would scatter near‑infrared light differently in the presence of a local electric field, allowing the wearable to read signals. Magnetoelectric particles would convert an external magnetic field into a local electric effect to stimulate neurons. The system must deliver particles to the target brain area, retain them, read the signal, and induce a local effect.

At the September 3 event, Kurzweil described the ultimate goal: “Ultimately we want to merge smartphone with brain.” A Science Advances 2021 study showed a related step: magnetoelectric particles injected into specific mouse brain areas were exposed to static and alternating magnetic fields. The combination of particles and both fields increased c‑Fos‑positive neurons and altered gait parameters in mice, confirming local stimulation.

Kurzweil will advise Subsense on product development, with the company’s first focus on neurological diseases. Subsense plans pilot clinical trials for 2027–2029.

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Starr Foundation Funds $37M Brown Aging Research Alliance

On September 3, Brown University announced the Starr Healthspan Innovation Alliance, a five‑year program backed by a $37 million grant from the Starr Foundation to link its Center for Biology of Aging with clinical trials run by Brown University Health. The initiative aims to translate laboratory discoveries into human studies by providing the researchers, trial teams, and participants needed for clinical testing.

Funds will cover laboratory work, the hiring of new researchers, and the expansion of the clinical research network. In addition, the grant will create two new endowed professorships in geroscience and support the recruitment of specialist staff.

Brown University Health currently conducts about 500 clinical trials in Rhode Island, with roughly two‑thirds focused on aging and related diseases. These trials provide a substantial platform for testing interventions that emerge from the Center for Biology of Aging.

The alliance will pay for specialists, participant recruitment and support through local communities, and will foster partnerships with scientific groups and industry. It builds on an organizational foundation established in 2

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AI system Astra drafts five NIH R01 grant proposals in under an hour

On September 6, Lokseyl posted on X that he asked Astra to read his published works, identify new directions, and prepare five drafts of R01 grant applications for the US National Institutes of Health. He noted that the task took about an hour and required roughly about $20 of computational resources.

One attached draft page poses a question about how cancer cell metabolism responds to enzyme inhibition when nutrient availability shifts, aiming to pinpoint which enzyme sets the reaction rate under those conditions. The draft builds on prior lab results to formulate a hypothesis that cellular nutrition, chemical state, and energy demand determine which step of glucose processing becomes rate‑limiting.

The first aim proposes varying nutrient conditions and the activity of three enzymes to see which step begins to limit flux. The second aim calls for comparing multiple mechanistic explanations with measurements and constructing a simplified model of the observed changes. The third aim requires pre‑registering predictions for new nutrient combinations and cell cultures, then testing them experimentally.

Lokseyl wrote that Astra “well reproduced this logic,” turning his existing work into questions, hypotheses, and experiments that would seem familiar and justified to an expert review panel. He judged all five drafts to be “quite reasonable,” grounded in his research and resembling a grant he himself might have written.

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Gene activity entropy varies with age and cancer across tissues

Researchers analyzed RNA from over 25 000 human and mouse tissue samples, computing Shannon entropy to measure whether gene activity is concentrated in few genes or spread across many. They first asked whether this entropy changes with age uniformly across the body. After adjusting for available sample characteristics, entropy decreased in brain, stomach, and blood; it increased in salivary gland, heart, skin, fat, and skeletal muscle; and remained stable in other tissues.

The age‑related pattern therefore differs by organ. To separate intracellular changes from shifts in cell‑type composition, the authors estimated cellular makeup mathematically; the entropy rise seen in skin and skeletal muscle persisted after this correction. In single‑cell data from liver cancer and melanoma, tumor cells often showed higher entropy even among cells of the same type.

In matched tumor‑normal pairs, primary tumors of most types had higher entropy than adjacent normal tissue. For melanoma, entropy rose from non‑sun‑exposed skin through primary tumor to late metastases, using skin and tumor data from separate cohorts. In 5 out of 6 paired melanoma samples that acquired therapy resistance, entropy increased.

Among cancer types where the link to overall survival was significant, high entropy accompanied worse survival in roughly ~70% of cases. In cellular reprogramming experiments, a less successful chemical protocol yielded higher entropy than a more successful one. The same entropy calculation reflects both cellular state and tissue composition, and its meaning depends on the specific organ and sample makeup. Aging Cell, 4 September

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Body‑Channel Communication Enables High‑Bandwidth Wireless Neural Implants

The main problem with modern wireless neuroimplants is the tight limits on bandwidth, power consumption, and heating: a high‑resolution microelectrode array (MEA) with 1000‑channel MEA generates a data stream exceeding 300 Mbps. Radio‑frequency transmission of this volume produces too much heat, inevitably damaging brain tissue.

The EU‑funded IoN (Intranet of Neurons) project tackled this with a two‑stage wireless architecture that uses body‑channel communication (BCC), treating the body’s tissues as a wire and abandoning

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TMP-316 improves hind‑limb weight bearing in rats after spinal cord injury

A preprint posted on bioRxiv, September 4 describes TMP-316, a compound that simultaneously inhibits four related branches of the AGC‑kinase family.

The authors started from RO48, which had shown spinal‑cord‑injury benefit in mice but also acted on the cardiac hERG channel and had short cerebrospinal‑fluid half‑life. They generated 371 analogues, screened them for neurite outgrowth and activity against S6K1 and ROCK2, and identified TMP-316 as the lead.

In neuronal cultures, inhibition of S6K1 and ROCK2 promoted neurite extension, and adding blockade of PKCγ or PKX further increased growth. All four kinases share an ATP‑binding pocket that modeling predicted TMP-316 could occupy.

In the animal study, male rats were randomly assigned to three groups (vehicle, ~0.3 mg/kg, or ~1 mg/kg TMP-316; n = 12‑13 per group). The compound was injected into the lumbar cerebrospinal‑fluid space immediately before a C5‑C6 contusion, and investigators assessing locomotion were blinded to treatment.

At the ~1 mg/kg dose, a composite gait score began to differ from controls on day 14, with the greatest divergence occurring between days 28 and 42. Motion analysis showed that the injured fore‑paw bore more weight and that bipedal support returned during stance.

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Fruit Fly Connectome Data Used to Simulate 'Bad Apple' Touhou Track

Researchers took recently published connectome data from adult male fruit flies and fed it into a neural simulation. They then translated the simulated neural activity into the melody of the Touhou song 'Bad Apple'.

The motion‑detecting neurons in the simulation directly controlled a virtual fly, making it move to the music. Looking ahead, one could imagine a digital copy of a person being forced to play internet meme tracks—a darkly humorous take on transhumanism.

🔗 Source: @solid_state_humanity

FishNAP screen identifies seven reversible blood‑brain barrier‑opening molecules

On September 4, researchers at Rutgers University released version 2 of a preprint describing the FishNAP assay, a zebrafish‑larvae screen for molecules that transiently increase blood‑brain barrier permeability. The assay first measures behavioral changes caused by loperamide entry into the brain, then quantifies leakage of a fluorescent tracer into brain tissue. FishNAP preprint, Rutgers University, version 2, September 4

They screened 2,320 FDA‑approved small molecules and found 11 that repeatedly altered larval behavior; direct tracer measurements confirmed seven compounds with pronounced passage of the smallest marker into the brain. All seven showed reversible barrier opening, with function restored within 24 hours after compound removal.

The three selected molecules—calcitriol, lovastatin, sunitinib—were tested in adult mice, where each increased tracer and albumin accumulation in brain tissue; calcitriol and lovastatin also allowed IgG entry. In cortical tissue, levels of CLDN5 and MFSD2A decreased while CAV1 increased, indicating loosened tight junctions and enhanced transcellular transport.

The authors link this protein pattern to weakened endothelial tight junctions and heightened vesicular transport, noting that FishNAP selects for small molecules that transiently alter vascular wall permeability. The method’s usefulness depends on the size of the intended cargo and which barrier property the hit compound modifies.

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We need to translate Russian news post into natural English, format per rules.

First line: short headline under 90 chars, no markdown, no '#'.

Then blank line, then body split into short paragraphs (2-3 sentences each), separated by blank lines.

Wrap few genuinely important facts — key numbers, percentages, drug/company/gene names, dates — in double asterisks . At most 4-5 per post, never a whole sentence.

Wrap study/journal citations and publication references in single underscores _ (e.g., Nature Aging, July 2026).

We need to preserve all facts, numbers, names, citations exactly. No added commentary.

We need to identify citations: The text mentions "статья с промежуточными данными регистра MASTRR: в десяти центрах США устройства Myriad применили у 411 пациентов с 474 сложными дефектами мягких тканей." No explicit journal name. Might be a study article but not given. We may need to wrap any citation like "статья" but we don't have journal name. Possibly we can treat "MASTRR" as registry name, not citation. No explicit journal citation given. So maybe we don't need any underscores. However we could still wrap the registry name? The rule: "Wrap study/journal citations and publication references in single underscores". If none present, we skip.

We need to wrap key numbers, percentages, drug/company/gene names, dates in double asterisks. At most 4-5 per post.

Important facts: 411 patients, 474 defects, 10 US centers, Myriad device, made from sheep rumen extracellular matrix, median follow-up 27.1 weeks, 50 patients (12.2%) had 59 adverse events, superficial infection 2.9%, deep infection 0.7%, skin reaction (likely related) led to removal of 40% of scaffold, antihistamines, split-thickness skin graft, registry ongoing, planned size 800 participants, primary endpoint proportion with adverse events over three years, article published September 3 (maybe date). Also "почти 60% дефектов сохранялись больше месяца" (almost 60% defects persisted >1 month). Also participants often had type 2 diabetes and vascular diseases.

We need to select at most 4-5 double asterisk wrapped items. Choose the most important: number of patients (411), number of defects (474), median follow-up (27.1 weeks), percentage with adverse events (12.2%), planned registry size (800). Also maybe date Sept 3. But we have limit 4-5. Let's pick: 411 patients, 474 defects, 27.1 weeks, 12.2%, 800 participants. That's 5.

We need to ensure we don't wrap whole sentence. Just wrap those numbers/percentages.

Also need to wrap drug/company/gene names: Myriad is a device name; could be considered a company/device name; we could wrap it but that would increase count. We already have 5 items; maybe we replace one with Myriad? But we need to keep numbers. The rule says "Wrap the few genuinely important facts — key numbers, percentages, drug/company/gene names, dates — in double asterisks. Be selective: at most 4-5 per post". So we can include drug/company names as part of the limited count. We need to decide which to include. Probably include Myriad as it's important. But we also need numbers. Let's see if we can fit 5 items: Myriad, 411 patients, 27.1 weeks, 12.2%, 800 participants. That's 5. Could also include 474 defects but we would exceed. Maybe we can combine "411 patients with 474 defects" as one phrase? But that would be a whole sentence? Not exactly; we could wrap "411 patients" and "474 defects" separately but that's two. Could we wrap "411 patients, 474 defects" as one? That includes two numbers but still one wrapped segment. The rule says wrap few genuinely important facts — key numbers, percentages, drug/company/gene names, dates. It doesn't forbid wrapping a phrase containing multiple numbers. So we could wrap "411 patients with 474 defects" as one item. That counts as one. Then we have Myriad, 27.1 weeks, 12.2%, 800 participants = total 5. Good.…

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