The review article describes a hypothesis according to which the drivers of epigenetic regulation in memory formation are mobile genetic elements that affect the expression of specific genes in the brain. In support of this hypothesis, the results of scientific studies on the regular activation of transposons in neuronal stem cells during neuronal differentiation are presented. These processes occur in the neurogenesis zone - the dentate gyrus of the hippocampus, where the greatest activity of mobile genetic elements and their insertions into loci near the genes expressed by neurons with their activation are determined. In experiments on changing the activity of histone acetyltransferase, inhibition of DNA methyltransferase and reverse transcriptase, the involvement of epigenetic factors and retroelements in the mechanisms of memory formation was shown. At the same time, a number of studies on different animals demonstrated the preservation of long-term memory without the participation of synaptic plasticity. The obtained data allow us to assume that transposons, which are highly sensitive genome sensors to various environmental and internal influences, form memory at the level of nuclear coding. This is reflected in the change in synaptic plasticity, which can explain the preservation of long-term memory after the elimination of synaptic connections in animals. This is confirmed by the facts of the origin of proteins directly involved in the formation of memory, including the transfer of genetic information through synapses between neurons (Arc protein), from mobile genetic elements. Transposons are sources of long non-coding RNA and microRNA, the role of which in memory consolidation has been described. Pathological activation of mobile genetic elements is a probable cause of neurodegenerative diseases with memory impairment. An analysis of the scientific literature allowed us to find data on changes in the expression of 40 microRNAs originating from transposons in Alzheimer's disease. For 24 of these microRNAs, the mechanisms of gene regulation involved in brain function have been described. It is suggested that the microRNAs we identified could become potential tools for regulating transposon activity in the brain to improve memory.
https://vavilov.elpub.ru/jour/article/view/4229
https://vavilov.elpub.ru/jour/article/view/4229
vavilov.elpub.ru
Гипотеза взаимосвязи эпигенетических факторов с транспозонами в формировании памяти | Мустафин | Вавиловский журнал генетики и…
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Forwarded from Relocation to Africa. Релокация в Африку с домом на океан (Longevity InTime Founder Oleg Teterin)
Baobab from Madagascar aged 10 years old in Singapore’s Flower Dome
They live over 5,000 years. But none saw them die ;-)
They live over 5,000 years. But none saw them die ;-)
https://www.microsoft.com/en-us/research/blog/exploring-the-structural-changes-driving-protein-function-with-bioemu-1/
Pre print:
https://www.biorxiv.org/content/10.1101/2024.12.05.626885v1
Pre print:
https://www.biorxiv.org/content/10.1101/2024.12.05.626885v1
Microsoft Research
AI is accelerating protein discovery
Meet BioEmu-1 from Microsoft Research. This deep learning model can generate thousands of protein structures per hour, unlocking new possibilities for protein scientists and drug discovery and research.
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Longevity InTime Founder speech in Singapore on the Longevity Founders event in Singapore, 28 of February 2025:
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These are the 6 most outstanding articles and/or videos published during the month of February on the "Rejuvenation Radar"
Articles and videos are all in English, though summaries of each one are in Spanish.
https://mailsystem.es/campaign-content/51723
Articles and videos are all in English, though summaries of each one are in Spanish.
https://mailsystem.es/campaign-content/51723
Donald Trunp in Qatar:
Signed so may investment agreements…
And nothing about longevity.
Unfortunately everyone aged over 30 years have only 350,000 hours left … and no one in this respectful delegation is not even noticing that « there is a giant asteroid coming towards everyone » and no one « looks up » ….
I devoted 6 years of my life to try to change this mindset of the most influential nigh profile individuals, the result is poor, the first 10 who will notice this « asteroid » will benefit in years of life and trillions of cash…
In my longevity world this post will be like this: « Donald Trump went to Qatar to sign 1T$ deal to fight aging and save 166,000 lives which does daily due to premature death causes »
But this is my perfect imaginary world
Longevity InTime will change the narrative, hopefully, in time, with you or without you
Signed so may investment agreements…
And nothing about longevity.
Unfortunately everyone aged over 30 years have only 350,000 hours left … and no one in this respectful delegation is not even noticing that « there is a giant asteroid coming towards everyone » and no one « looks up » ….
I devoted 6 years of my life to try to change this mindset of the most influential nigh profile individuals, the result is poor, the first 10 who will notice this « asteroid » will benefit in years of life and trillions of cash…
In my longevity world this post will be like this: « Donald Trump went to Qatar to sign 1T$ deal to fight aging and save 166,000 lives which does daily due to premature death causes »
But this is my perfect imaginary world
Longevity InTime will change the narrative, hopefully, in time, with you or without you
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