Lab Rats In Lab Coats
Some random notes on DM therapy:
Non-insulin therapy
• GLP1 & SGLT2 have a mAcrovascular protective effect.
SGLT2 in particular protects against heart failure & diabetic kidney disease.
• TZDs (pioglitazone) increases rates of HF & hepatotoxicity. Rosiglitazone is not used anymore due to these reasons.
• Metformin can cause lactic acidosis especially in RF.
• Sulfonylureas, on the other hand, can cause significant hypoglycemia. They also lose their effect (and cause total B-cell failure) after long-term use "sulfonylurea failure."
• They lead to weight gain too.
• DPP-4 drugs (all end in -liptin) shouldn't be used with GLP1.
• SGLT2 (all end in -flozin) is really fucking good. But use it cautiously with DM-1 as it can precipitate euglycemic DKA.
• SGLT2 & Metformin are euglycemic agents (do not cause hypoglycemia).
• the GLP1 guys all end in -tide
• GLP1 & SGLT2 have a mAcrovascular protective effect.
SGLT2 in particular protects against heart failure & diabetic kidney disease.
• TZDs (pioglitazone) increases rates of HF & hepatotoxicity. Rosiglitazone is not used anymore due to these reasons.
• Metformin can cause lactic acidosis especially in RF.
• Sulfonylureas, on the other hand, can cause significant hypoglycemia. They also lose their effect (and cause total B-cell failure) after long-term use "sulfonylurea failure."
• They lead to weight gain too.
• DPP-4 drugs (all end in -liptin) shouldn't be used with GLP1.
• SGLT2 (all end in -flozin) is really fucking good. But use it cautiously with DM-1 as it can precipitate euglycemic DKA.
• SGLT2 & Metformin are euglycemic agents (do not cause hypoglycemia).
• the GLP1 guys all end in -tide
Insulin therapy
• Add zinc/protamine to your regular (short-acting) insulin, and it becomes a long-acting insulin (called isophane or NPH insulin). Add a lot more zinc ions, and it becomes (lente insulin).
• Liver & renal disease delay insulin breakdown in the body.
• Add zinc/protamine to your regular (short-acting) insulin, and it becomes a long-acting insulin (called isophane or NPH insulin). Add a lot more zinc ions, and it becomes (lente insulin).
• Liver & renal disease delay insulin breakdown in the body.
صور جان لازم ادزهن قبل الباطنية والنسائية، بس اني نفسي جنت ناسيهن موجودات...
Lab Rats In Lab Coats
Reasons why doctors sometimes get the diagnosis wrong
Heuristic (n.)
It's a mental shortcut, a way of making decisions quickly based on past experiences or some pre-formed ideas. A heuristic method is a method that trades some accuracy for a quicker decision. It's what we call an instinct or a hunch.
It's a mental shortcut, a way of making decisions quickly based on past experiences or some pre-formed ideas. A heuristic method is a method that trades some accuracy for a quicker decision. It's what we call an instinct or a hunch.
Lab Rats In Lab Coats
Reasons why doctors sometimes get the diagnosis wrong
You are more likely to encounter rare manifestations of a common disease than typical manifestations of a rare disease.
(Bayes theorem applied to diagnostics)
(Bayes theorem applied to diagnostics)