كلش مهم تنتبه لإحتمالية وجود الـ WE لأنها underdiagnosed

Korsakoff syndrome (KS) is a late neuropsychiatric manifestation of Wernicke encephalopathy (WE) in which there is a striking disorder of selective anterograde and retrograde amnesia. Although this memory disorder can occur in a variety of conditions that damage the medial temporal lobes, KS is seen most frequently in individuals with alcohol use disorder after an episode of WE, and most patients with KS show typical WE lesions. Any condition that can lead to thiamine loss and WE can also be a cause of KS. 

In some individuals with alcohol use disorder, KS develops without a recognized acute episode of WE, although typical WE lesions may be present at autopsy.

Clinical features:
KS is characterized by marked deficits in anterograde and retrograde memory, apathy, an intact sensorium, and relative preservation of long-term memory and other cognitive skills. Confabulation is a feature in some but not all cases. Attention and social behavior are relatively preserved. Affected subjects are able to carry on a socially appropriate conversation that may seem normal to an unsuspecting spectator. Patients with KS are as a rule unaware of their illness.

atrophy of the mamillary bodies is a relatively specific sign of prior WE, and the finding of small mamillary bodies in a patient with dementia should raise the possibility that alcohol use disorder and malnutrition have contributed to the dementia.

Always suspect WE in alcoholic patients

تقريبا يكلك شكو شخص جاي شارب وديهادريتد وعدة نيورو سمبتمز فكر ب ورنكيز

ودول شرق اسيا اليعتمدون علتمن باكلهم وحده همين يصير عدهم من الثايمين دفشنسي

بالضبط، WE ما يصيب فقط مدمني الكحول. أي مرض يسبب نقص الـ B1 رح يؤدي للـ WE:
أمراض الجهاز الهضمي، سوء التغذية، وحتى hyperemesis gravidarum.

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Seen in schwannoma, meningioma (fibrous type) and many other types of tumors.

Seen in almost all cases glioblastoma multiforme. It's almost a pathognomonic feature of the tumor.

Survival estimates for astrocytomas

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واحد طلع

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