Lab Rats In Lab Coats
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Lab Rats In Lab Coats
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ذكرتيني اريد ارجع لسوالف ال U/S
Forwarded from 0/0 (Haidar A. Fahad)
Quail (Coturnix coturnix)
طائر السمان
Forwarded from 0/0 (Haidar A. Fahad)
Coturnism
Forwarded from 0/0 (Haidar A. Fahad)
0/0
Coturnism
السمان مشهور بمنطقة البحر الأبيض المتوسط بصفته قابل للأكل من آلاف السنين.
بس بشكل نادر، لما البشر يستهلكون بعض هاي الطيور، رح يتسممون وتظهر عليهم أعراض الفشل الكلوي AKI وتحلل العضلات Rhabdomyolysis وممكن يموتون. الحالة هاي يسموها Coturnism. يُعتَقَد أنّ بعض طيور السمان (مو كلها، ولا حتى أغلبها) أثناء موسم الهجرة تستهلك نباتات سامة بالصدفة، مثل الشوكران Hemlock بدون ما تتسمم أو تتأذى، بس المواد السامة بالشوكران رح تبقى بأجسام هاي الطيور لحدما يستهلكها انسان غير محظوظ وتنلاص عليه.

التسمم بسبب أكل لحوم السمان معروف من آلاف السنين من أيام اليونانيين والرومان. حتى الكتاب المقدس يذكر أنّ بني إسرائيل بسيناء صادوا بعض هاي الطيور وتسمموا بيها عقابًا من الله [سِفر الأعداد 11:31].
Forwarded from 0/0 (Haidar A. Fahad)
أمّا الشوكران Hemlock فهو أيضًا مشهور من آلاف السنين (نفسه النبات اللي انتحر بيه سقراط) ومعروف بسمّيته بسبب مادة الـ Coniine اللي هي Nicotinic-receptor antagonist تؤثر على الجهاز العصبي وتسبب flaccid paralysis وبالنهاية، شلل لعضلات التنفس.
Tumor-lysis syndrome (TLS) &
Rhabdomyolysis
The classic triad of rhabdo:

- dark urine (myoglobinuria)
- myalgia (muscle pain)
- muscle weakness
This triad exists only in about 50% of patients.
Lab Rats In Lab Coats
Tumor-lysis syndrome (TLS) & Rhabdomyolysis
They both cause:

- Hyperuricemia.
- Hyperkalemia.
- Hyperphosphatemia.
- Hypocalcemia (but can become hypercalcemia in later stages).
- Hypoalbuminemia (due to AKI).
- Rhabdo alone causes myoglobinuria.
A case of Rhabdomyolysis

A 28-year-old woman is admitted to the emergency department in a coma. The patient was found unconscious on the floor by her boyfriend. She had not been seen by anyone for the previous 48 h. No history was available from the patient, but her partner volunteered the information that they are both intravenous heroin addicts. She is unemployed, smokes 25 cigarettes per day, drinks 40 units of alcohol per week and has used heroin for the past 4 years. They have occasionally shared needles with other addicts. They both had negative HIV tests about 1 year ago. She has not made any suicide attempts in the past. She has had no other medical illnesses.

On examination, there are multiple old scarred needle puncture sites. Her PR is 64/min regular, BP 110/60 mmHg, JVP not raised, heart sounds normal. Her RR is 12/min, and she has dullness to percussion and bronchial breathing at the left base posteriorly. Abdominal examination is normal. Her conscious level is depressed but she is rousable to painful stimuli. She has pinpoint pupils, but has no focal neurological signs. A bolus injection of intravenous naloxone causes her conscious level to rise transiently. Her left arm is swollen and painful from the shoulder down.