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Forwarded from 0/0 (Haidar A. Fahad)
Malaria is characterized by febrile paroxysm; recurrent alternating episodes of shivers and fever that usually begin in the night.
This is because the infection cycle of plasmodium (Malaria) occurs in a highly synchronous fashion, with roughly all of the parasites throughout the blood in the same stage of development, so the infected RBCs rupture and cause systemic inflammatory response roughly at the same time.
This precise clocking mechanism has been shown to be dependent on the human host's own circadian rhythm.
This is because the infection cycle of plasmodium (Malaria) occurs in a highly synchronous fashion, with roughly all of the parasites throughout the blood in the same stage of development, so the infected RBCs rupture and cause systemic inflammatory response roughly at the same time.
This precise clocking mechanism has been shown to be dependent on the human host's own circadian rhythm.