MCQ NO 841 | Pharmacology
Anticancer drugs weaken host defence by:
Anticancer drugs weaken host defence by:
Anonymous Quiz
12%
A. Damaging respiratory and gut epithelia
16%
B. Inducing granulocytopenia
15%
C. Altering resident microbial flora
57%
D. Both 'A' and 'B' are correct
MCQ NO 842 | Pharmacology
Practically all antineoplastic drugs can produce the following toxic effects except:
Practically all antineoplastic drugs can produce the following toxic effects except:
Anonymous Quiz
25%
A. Depression of leucocyte count
21%
B. Mucositis
26%
C. Cardiomyopathy
27%
D. Oligozoospermia
MCQ NO 843 | Pharmacology
Alkylating agents exert cytotoxic action by inducing:
Alkylating agents exert cytotoxic action by inducing:
Anonymous Quiz
9%
A. Breakage of DNA strand
21%
B. Cross linking of DNA strands
21%
C. Abnormal pairing of purine and pyrimidine bases
49%
D. All of the above
MCQ NO 844| Pharmacology
The following is true of cyclophosphamide except:
The following is true of cyclophosphamide except:
Anonymous Quiz
25%
A. It is highly reactive and a vesicant on contact
29%
B. It is a prodrug
31%
C. It has marked immunosuppressant property
15%
D. It frequently causes alopecia and cystitis
MCQ NO 845| Pharmacology
The most important target of action of chlorambucil is:
The most important target of action of chlorambucil is:
Anonymous Quiz
30%
A. Myeloid tissue
47%
B. Lymphoid tissue
13%
C. Neural tissue
10%
D. Skin
MCQ NO 846 | Pharmacology
Methotrexate has the following attributes except:
Methotrexate has the following attributes except:
Anonymous Quiz
17%
A. It is cell cycle specific and kills cells in the S phase
35%
B. Its toxicity primarily affects bone marrow and epithelial structures
31%
C. Folic acid reverses its toxic effects
17%
D. It is the drug of choice for choriocarcinoma
MCQ NO 847 | Pharmacology
The following antineoplastic drug is a mitotic inhibitor and causes metaphase arrest:
The following antineoplastic drug is a mitotic inhibitor and causes metaphase arrest:
Anonymous Quiz
16%
A. Busulfan
55%
B. Vincristine
19%
C. Cytarabine
10%
D. Procarbazine
MCQ NO 848 | Pharmacology
Vinca alkaloids exert antitumor activity by:
Vinca alkaloids exert antitumor activity by:
Anonymous Quiz
18%
A. Activating topoisomerase II to cause breaks in DNA strands
12%
B. Crosslinking DNA strands
17%
C. Inhibiting DNA mediated RNA synthesis
53%
D. Inhibiting polymerization of tubulin to form intracellular microtubules
MCQ NO 849 | Pharmacology
The following cytotoxic drug acts by inhibiting depolymerization of tubulin and thus producing abnormal arrays of microtubules:
The following cytotoxic drug acts by inhibiting depolymerization of tubulin and thus producing abnormal arrays of microtubules:
Anonymous Quiz
25%
A. Paclitaxel
52%
B. Vinblastine
15%
C. Etoposide
8%
D. Mitoxantrone
MCQ NO 850 | Pharmacology
Vincristine differs from vinblastine in the following respect(s):
Vincristine differs from vinblastine in the following respect(s):
Anonymous Quiz
14%
A. Its prominent adverse effect is neuropathy
12%
B. It frequently produces alopecia
17%
C. It does not significantly depress bone marrow
57%
D. All of the above
MCQ NO 851 | Pharmacology
What is true of docetaxel:
What is true of docetaxel:
Anonymous Quiz
20%
A. It is used as a reserve drug for refractory breast and ovarian cancer
22%
B. It is a selective estrogen receptor modulator used for breast cancer
10%
C. It is effective only in estrogen receptor positive breast cancer
48%
D. Both 'B' and 'C' are correct
MCQ NO 852 | Pharmacology
Choose the correct statement about topotecan:
Choose the correct statement about topotecan:
Anonymous Quiz
30%
A. It is a DNA topoisomerase I inhibitor which causes single strand DNA breaks
17%
B. It is a cell cycle specific anticancer drug
16%
C. It is a COMT-inhibitor used in advanced parkinsonism
37%
D. Both 'A' and 'B' are correct
MCQ NO 853 | Pharmacology
The characteristic toxicity of doxorubicin is:
The characteristic toxicity of doxorubicin is:
Anonymous Quiz
18%
A. Kidney damage
26%
B. Liver damage
45%
C. Cardiomyopathy
11%
D. Pulmonary fibrosis
MCQ NO 854 | Pharmacology
Thioguanine differs from mercaptopurine in that:
Thioguanine differs from mercaptopurine in that:
Anonymous Quiz
15%
A. It is not metabolized by xanthine oxidase
17%
B. It does not cause hyperuricemia
22%
C. Its dose need not be reduced when allopurinol is given concurrently
46%
D. Both ‘A’ and ‘C’ are correct
MCQ NO 855 | Pharmacology
Patients treated with the following anticancer drug are likely to develop a disulfiram like reaction on taking alcohol:
Patients treated with the following anticancer drug are likely to develop a disulfiram like reaction on taking alcohol:
Anonymous Quiz
15%
A. Dacarbazine
49%
B. Procarbazine
25%
C. Melphalan
11%
D. Hydroxyurea
MCQ NO 856 | Pharmacology
The following is true about use of prednisolone in malignant diseases except:
The following is true about use of prednisolone in malignant diseases except:
Anonymous Quiz
15%
A. It is curative in acute childhood leukaemia
28%
B. It is used in Hodgkin’s disease
41%
C. It controls hypercalcaemia in patients with bony metastasis
16%
D. It affords symptomatic relief in most cancer patients
MCQ NO 857 | Pharmacology
Select the cell cycle nonspecific antineoplastic drug:
Select the cell cycle nonspecific antineoplastic drug:
Anonymous Quiz
28%
A. Vincristine
29%
B. Bleomycin
20%
C. Methotrexate
23%
D. 5-Fluorouracil
MCQ NO 858 | Pharmacology
Mesna is administered with cyclophosphamide and ifosphamide to:
Mesna is administered with cyclophosphamide and ifosphamide to:
Anonymous Quiz
23%
A. Potentiate their cytotoxic action
22%
B. Retard their renal excretion
26%
C. Block their emetic action
29%
D. Ameliorate cystitis caused by them
MCQ NO 859 | Pharmacology
What is true of thalidomide:
What is true of thalidomide:
Anonymous Quiz
15%
A. It exerts antitumour activity in some solid malignant tumours
18%
B. It ameliorates cancer associated cachexia
10%
C. It exerts antileprotic action
58%
D. All of the above