🔴 Mechanism of Action 🔴

🔺Nonsteroidal Antiinflammatory Drugs :-

NSAIDs maily act by the inhibit function of Cyclooxygenase enzyme (COX 1& 2)

Cyclooxygenase enzyme responsible for synthesis of prostaglandin. (You know prostaglandin shows Afferent nerve sensations)

So, NSAIDs simply block COX enzyme & reduce pain sensation and inflammation like prostaglandin effects.

Some NSAIDs also selective for COX1 & COX2.

Some NSAIDs acts antipyretics e. g. Paracetamol.

🔺Beneficial Actions due to Prostaglandin synthesis inhibition.

1.Analgesia (prevention of pain nerve ending sensitization)
2.Antipyresis
3.Antiinflammatory
4.Antithrombotic
5.Closure of ductus arteriosus in newborn.

🔴ADR OF NSAIDS🔴

➡️Ulcers
➡️Bleeding
➡️Kidney failure
➡️Rarely liver failure

🔴 Mechanism of Action 🔴

🔺Antirheumatoid Drugs:-

Some important classes of drugs shows mechanism as follows & gives antirheumatic action....

Rheumatoid arthritis (RA) is an autoimmune disease in which there is joint inflammation, synovial proliferation and destruction of articular cartilage.

1. Immunosupressants
Inhibit I. cytokine production
II. Chemotaxis
III. Cell mediated
immune reaction

2.TNF alpha inhibitors acts by inhibiting the cytokine TNF alpha (plays important role in inflammatory cascade by activating membrane bound receptor TNFR1 and TNFR2)



Actually these two receptors present on T-cell surface & macrophages.

So, TNF alpha inhibitors mainly suppress the function of macrophages and T-cell.

🔴ADR OF DMARD'S🔴

➡️Upset stomach
➡️Nausea
➡️Diarrhea
➡️Hair loss
➡️Mouth sores
➡️Rash or serious skin reactions
➡️Liver,kidney or lung problems