MCQ NO 927 | Biochemistry
Streptomycin prevents synthesis of polypeptide by ?
Streptomycin prevents synthesis of polypeptide by ?
Anonymous Quiz
15%
Inhibiting initiation proces
17%
Releasing premature polypeptide
58%
Inhibiting peptidyl transferase activity
9%
Inhibiting translocation
MCQ NO 928 | Biochemistry
Presence of arginine can be detected by........
Presence of arginine can be detected by........
Anonymous Quiz
25%
Gas chromatography
26%
Million-Nasse reaction
23%
Hopkins-Cole reaction
26%
Sakaguchi reaction
MCQ NO 929 | Biochemistry
During de novo synthesis of pyrimidine nucleotides, the first ring compound to be formed is?
During de novo synthesis of pyrimidine nucleotides, the first ring compound to be formed is?
Anonymous Quiz
24%
Dihydro-orotic acid
16%
Orotic acid
41%
Carbamoyl aspartic acid
19%
Orotidine monophosphate
MCQ NO 930 | Biochemistry
In mammalian cell cycle, synthesis of DNA occurs during......
In mammalian cell cycle, synthesis of DNA occurs during......
Anonymous Quiz
21%
G2 phase
21%
G1 phase
43%
S phase
15%
Mitotic Phase
🔴 Mechanism of Action 🔴
🔺 Corticosteroids :-
Corticosteroids secreted from Cortex of Adrenal gland...
Adrenal cortex has 3 regions..
a. Outer region Zona glomerulosa.... Secretes Mineralocorticods. ( Aldosterone)
b. Middle region Zona fasciculata..... Secretes Glucocorticoids. ( Hydrocortisone)
C. Inner region Zona reticularis ... Secretes Andrigens (dihydroepiandrosterone)
🔴 Mechanism of Action 🔴
🔺 Mineralocorticoids:-
Principle mineralocorticoid is Aldosterone... Action is enhancement of SODIUM reabsorption from distal convoluted tubules in kidney.
This corticosteroid also increases the in POTASSIUM and HYDROGEN ( proton) excretion.
The action of aldosterone is exerted by gene mediated increased transcription of m-RNA in renal tubule cells which directs synthesis of proteins (aldosterone induced proteins --- AIPs). These proteins acts on mitochondria to generate energy (ATP) and also synthesize the beta subunit of amiloride sensitive SODIUM channel.
So, Na* K* ATPase pump located on tubular basolateral membrane responsible for generating gradients for movement if cations in these cells is the major AIP.
In addition, aldosterone rapidly induces phosphorylation and activation of amiloride sensitive sodium channel.
🔺 Corticosteroids :-
Corticosteroids secreted from Cortex of Adrenal gland...
Adrenal cortex has 3 regions..
a. Outer region Zona glomerulosa.... Secretes Mineralocorticods. ( Aldosterone)
b. Middle region Zona fasciculata..... Secretes Glucocorticoids. ( Hydrocortisone)
C. Inner region Zona reticularis ... Secretes Andrigens (dihydroepiandrosterone)
🔴 Mechanism of Action 🔴
🔺 Mineralocorticoids:-
Principle mineralocorticoid is Aldosterone... Action is enhancement of SODIUM reabsorption from distal convoluted tubules in kidney.
This corticosteroid also increases the in POTASSIUM and HYDROGEN ( proton) excretion.
The action of aldosterone is exerted by gene mediated increased transcription of m-RNA in renal tubule cells which directs synthesis of proteins (aldosterone induced proteins --- AIPs). These proteins acts on mitochondria to generate energy (ATP) and also synthesize the beta subunit of amiloride sensitive SODIUM channel.
So, Na* K* ATPase pump located on tubular basolateral membrane responsible for generating gradients for movement if cations in these cells is the major AIP.
In addition, aldosterone rapidly induces phosphorylation and activation of amiloride sensitive sodium channel.
🔴ADRS🔴
✔️MINERALOCORTICOIDS
▶️Sodium and water retension
▶️Edema
▶️Hypokalaemic alkalosis
▶️Progressively rise bp
✔️GLUCOCORTICOIDS
▶️Cushing habitus
▶️Fragile skin
▶️Hypoglycemia
▶️Peptic ulcer
▶️Osteoporosis
✔️MINERALOCORTICOIDS
▶️Sodium and water retension
▶️Edema
▶️Hypokalaemic alkalosis
▶️Progressively rise bp
✔️GLUCOCORTICOIDS
▶️Cushing habitus
▶️Fragile skin
▶️Hypoglycemia
▶️Peptic ulcer
▶️Osteoporosis
MCQ NO 931 | medicinal chemistry
……………..has an oral to parenteral effectiveness ratio of 2:1 as the strong narcotics.
……………..has an oral to parenteral effectiveness ratio of 2:1 as the strong narcotics.
Anonymous Quiz
25%
a) Dihydroxycodine
43%
b) Codine
22%
c) Levorphanol
10%
d) Ethylmorphine
MCQ NO 932 | medicinal chemistry
Methadone is metabolized by enzyme………..
Methadone is metabolized by enzyme………..
Anonymous Quiz
39%
A .CYP3A4
16%
B. CYP2B6
14%
C. CYP2D6
31%
D. All of the above
MCQ NO 933 | medicinal chemistry
C15H21NO2 is the molecular formula for …………….opioid Analgesics.
C15H21NO2 is the molecular formula for …………….opioid Analgesics.
Anonymous Quiz
17%
a) Levorphanol
44%
b) Dextromethorphan
24%
c) Dihydroxycodine
15%
d) Meperidine
MCQ NO 934 | medicinal chemistry
Meperidine as a potential ………. Agent.
Meperidine as a potential ………. Agent.
Anonymous Quiz
14%
a) Anticholinergic
11%
b) Adrenergic
16%
c) Parasympatholytic
59%
d) Both 1 & 3
MCQ NO 935 | medicinal chemistry
Which of the following drugs is a leucotreine D4 receptor (LTD4) blocker?
Which of the following drugs is a leucotreine D4 receptor (LTD4) blocker?
Anonymous Quiz
13%
a) Ibuprofen
27%
b) Zileuton (Zyflo)
53%
c) Zafirleukast (Accolate)
8%
d) Diclofenac
MCQ NO 936 | Biochemistry
Calcium is required for the activation of the enzyme..........
Calcium is required for the activation of the enzyme..........
Anonymous Quiz
30%
Isocitrate dehydrogenase
13%
Fumarase
30%
Succinate thiokinase
27%
ATPase
MCQ NO 937 | Biochemistry
Which of the following features are present in blood chemistry in uncompensated metabolic alkalosis except?
Which of the following features are present in blood chemistry in uncompensated metabolic alkalosis except?
Anonymous Quiz
17%
Increased pH
41%
Increased bicarbonate
23%
Normal chloride
19%
Normal pCO2
MCQ NO 938 | Medicinal chemistry
A diuretic which is an aldosterone antagonist is?
A diuretic which is an aldosterone antagonist is?
Anonymous Quiz
64%
Spironolactone
14%
Ethacrynic acid
17%
Acetazolamide
5%
Chlorothiazide
MCQ NO 939 | medicinal chemistry
Thiazide diuretics inhibit:-
Thiazide diuretics inhibit:-
Anonymous Quiz
20%
Carbonic anhydrase
14%
Aldosterone secretion
14%
ADH secretion
53%
Sodium reabsorption in distal tubules
MCQ NO 940 | Pharmacology
Antidiuretic hormone is.....
Antidiuretic hormone is.....
Anonymous Quiz
23%
secreted by hypothalamus
27%
Secretion is increased when osmolality of plasma decreases
18%
Increases obligatory reabsorption of water
31%
Acts on distal convoluted tubules and collecting ducts
MCQ NO 941 | Physical Pharmacy
Which three factors affect the rate of a chemical reaction?
Which three factors affect the rate of a chemical reaction?
Anonymous Quiz
20%
(a) temperature, pressure and humidity
50%
(b) temperature, reactant concentration and catalyst
24%
(c) temperature, reactant concentration and pressure
6%
(d) temperature, product concentration and container volume
MCQ NO 942 | Physical Pharmacy
The rate law relates the rate of a chemical reaction to
The rate law relates the rate of a chemical reaction to
Anonymous Quiz
58%
(a) the concentrations of reactants
14%
(b) the temperature
22%
(c) the activation energy
6%
(d) reaction mechanism
MCQ NO 943 | Physical Pharmacy
For a reaction, A→ products a graph of [A] versus time is found to be a straight line. What is the order this reaction?
For a reaction, A→ products a graph of [A] versus time is found to be a straight line. What is the order this reaction?
Anonymous Quiz
46%
(a) zero order
43%
(b) first order
10%
(c) second order
2%
(d) third order
MCQ NO 944 | Physical Pharmacy
As temperature increases, the reaction rate .....
As temperature increases, the reaction rate .....
Anonymous Quiz
13%
(a) decrease than increase
22%
(b) decreases
63%
(c) increases
2%
(d) stays the same