MCQ NO 761 | Pharmacology
Patients treated with the following anticancer drug are likely to develop a disulfiram like reaction on taking alcohol:
Patients treated with the following anticancer drug are likely to develop a disulfiram like reaction on taking alcohol:
Anonymous Quiz
16%
A .Dacarbazine
45%
B. Procarbazine
29%
C. Melphalan
9%
D. Hydroxyurea
MCQ NO 762 | Pharmacology
The following is true about use of prednisolone in malignant diseases except:
The following is true about use of prednisolone in malignant diseases except:
Anonymous Quiz
21%
A. It is curative in acute childhood leukaemia
28%
B. It is used in Hodgkin’s disease
33%
C. It controls hypercalcaemia in patients with bony metastasis
18%
D. It affords symptomatic relief in most cancer patients
MCQ NO 763 | Pharmacology
The following does not apply to cancer chemotherapy:
The following does not apply to cancer chemotherapy:
Anonymous Quiz
29%
A. Each treatment with a cytotoxic drug kills a constant number of malignant cells
25%
B. Drugs are generally used at maximum tolerated doses
26%
C.same regimen which palliative for large solid tumour may curative after surgical removal of tumour
20%
D.Combination regimens using several drugs in succession are superior to single drug used continuous
MCQ NO 764 | Pharmacology
Select the cell cycle nonspecific antineoplastic drug:
Select the cell cycle nonspecific antineoplastic drug:
Anonymous Quiz
26%
A. Vincristine
25%
B. Bleomycin
25%
C. Methotrexate
23%
D. 5-Fluorouracil
MCQ NO 765 | Pharmacology
Transdermal drug delivery systems offer the following advantages except:
Transdermal drug delivery systems offer the following advantages except:
Anonymous Quiz
21%
A. They produce high peak plasma concentration of the drug
31%
B. They produce smooth and nonfluctuating plasma concentration of the drug
26%
C. They minimise interindividual variations in the achieved plasma drug concentration
22%
D. They avoid hepatic first-pass metabolism of the drug
MCQ NO 766 | Hospital and clinical pharmacy
Concept of District hospital :
Concept of District hospital :
Anonymous Quiz
10%
A.Clinical service
10%
B.Clinical support
16%
C.Only A
63%
D.Both A&B
MCQ NO 767 | Pharmacology
Following a constant infusion: *
Following a constant infusion: *
Anonymous Quiz
24%
A. the time to reach a plateau concentration depends upon the rate of infusion
37%
B.all drugs having same clearance reach same plateau concentration when infused at the same rate
26%
C drugs with the same clearance generally reach the plateau concentration at the same time
13%
D amt of drug at plateau can't same when drugs with different clearance values infused at same rate
MCQ NO 768 l Pharmacology
Essential drugs are:
Essential drugs are:
Anonymous Quiz
17%
A.Life saving drugs
59%
B.Drugs that meet the priority health care needs of population
15%
C.Drugs that must be present in the emergency bag of doctor
8%
D.Drugs that are listed in tha pharmacopoia of country
MCQ NO 769 l Pharmacology
An 'orphan drug' is....
An 'orphan drug' is....
Anonymous Quiz
6%
A.A very cheap drug
10%
B.A drug which has no therapeutic use
76%
C.A drug needed for treatment or prevention of rare disease
9%
D.A drug which acts on Orphanin receptors
MCQ NO.770 I Pharmacology
Drug administered through the following route is most likely to be subjected to first-pass metabolism:
Drug administered through the following route is most likely to be subjected to first-pass metabolism:
Anonymous Quiz
74%
A.Oral
14%
B.Sublingual
8%
C.Subcutaneous
4%
D.Rectal
🔴DEFINITION
🔶Molality =
Molality is defined as the “total moles of a solute contained in a kilogram of a solvent.”
🔶Molarity=
Molarity is defined as the "number of moles of solute per liter of solution."
🔶Capsule=
Capsules are solid dosage forms in which one or more medicament or inert substances are enclosed within a small shell generally prepared from gelatin.
🔶Tablets=
Tablets may be defined as compressed solid unit dosage form of medicament or medicaments with suitable excipients.
🔶Normality
is a measure of concentration equal to the gram equivalent weight per litre of solution.
🔶Molality =
Molality is defined as the “total moles of a solute contained in a kilogram of a solvent.”
🔶Molarity=
Molarity is defined as the "number of moles of solute per liter of solution."
🔶Capsule=
Capsules are solid dosage forms in which one or more medicament or inert substances are enclosed within a small shell generally prepared from gelatin.
🔶Tablets=
Tablets may be defined as compressed solid unit dosage form of medicament or medicaments with suitable excipients.
🔶Normality
is a measure of concentration equal to the gram equivalent weight per litre of solution.
🔴 DEFINITION
🔶Histamine =
Histamine a compound which is released by cells in response to injury and in allergic and inflammatory reactions, causing contraction of smooth muscle and dilation of capillaries.
🔶Histamine agonist =
A histamine agonist is a drug which causes increased activity at one or more of the four histamine receptor subtypes.
🔶Amines=
Amines an organic compound derived from ammonia by replacement of one or more hydrogen atoms by organic groups.
🔶Vaccines =
Vaccines are the antigenic material consisting of the whole microorganisms or one of its products.
🔶Erosion corrosion =
Erosion is mechanical process and corrosion is a electro chemical process. They combine in a situation to protect metal from the corrosion.
🔶Histamine =
Histamine a compound which is released by cells in response to injury and in allergic and inflammatory reactions, causing contraction of smooth muscle and dilation of capillaries.
🔶Histamine agonist =
A histamine agonist is a drug which causes increased activity at one or more of the four histamine receptor subtypes.
🔶Amines=
Amines an organic compound derived from ammonia by replacement of one or more hydrogen atoms by organic groups.
🔶Vaccines =
Vaccines are the antigenic material consisting of the whole microorganisms or one of its products.
🔶Erosion corrosion =
Erosion is mechanical process and corrosion is a electro chemical process. They combine in a situation to protect metal from the corrosion.
🔴 MECHANISM OF ACTION 🔴
📌 HISTAMINE
▪Histamine is an organic nitrogenous compound involved in local immune responses, as well as regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus.
▪ Histamine is involved in the inflammatory response and has a central role as a mediator of itching.
▪As part of an immune response to foreign pathogens, histamine is produced by basophils and by mast cells found in nearby connective tissues.
▪Histamine increases the permeability of the capillaries to white blood cells and some proteins, to allow them to engage pathogens in the infected tissues.
▪ It consists of an imidazole ring attached to an ethylamine chain; under physiological conditions, the amino group of the side-chain is protonated
📌 histamine exerts its effects primarily by binding to G protein-coupled histamine receptors, designated H1 to H4
📌 HISTAMINE
▪Histamine is an organic nitrogenous compound involved in local immune responses, as well as regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus.
▪ Histamine is involved in the inflammatory response and has a central role as a mediator of itching.
▪As part of an immune response to foreign pathogens, histamine is produced by basophils and by mast cells found in nearby connective tissues.
▪Histamine increases the permeability of the capillaries to white blood cells and some proteins, to allow them to engage pathogens in the infected tissues.
▪ It consists of an imidazole ring attached to an ethylamine chain; under physiological conditions, the amino group of the side-chain is protonated
📌 histamine exerts its effects primarily by binding to G protein-coupled histamine receptors, designated H1 to H4
MCQ NO.771 | Pathophysiology
Which cytokine functions as an activator of macrophages and natural killer (NK) cells?
Which cytokine functions as an activator of macrophages and natural killer (NK) cells?
Anonymous Quiz
15%
IFN-γ (interferon γ)
31%
IL-2 (interleukin 2)
47%
TNF-α (tumor necrosis factor α)
8%
TGF-β (transforming growth factor β)
MCQ NO.772 | Pathophysiology
Which one of the following genetic diseases is a chromosomal disorder?
Which one of the following genetic diseases is a chromosomal disorder?
Anonymous Quiz
15%
Cystic fibrosis
15%
Hemochromatosis
48%
Klinefelter’s syndrome
22%
Hemophilia
MCQ NO.773 | Pathophysiology
Which one of the following organisms accounts for at least 50% of cases of acute hematogenous and contiguous focus osteomyelitis?
Which one of the following organisms accounts for at least 50% of cases of acute hematogenous and contiguous focus osteomyelitis?
Anonymous Quiz
13%
Group A streptococci
39%
Group B streptococci
42%
Pseudomonas aeruginosa
6%
S. aureus
MCQ NO.774 | OC
In pinacol-pinacolone rearrangement, the final product is ketone. What is the starting compound for the rearrangement?
In pinacol-pinacolone rearrangement, the final product is ketone. What is the starting compound for the rearrangement?
Anonymous Quiz
15%
Geminal diol
53%
1,2- diol
28%
1, 3-diol
4%
1,1-diol
MCQ NO.775 | OC
Nitrites are used in ailments as:
Nitrites are used in ailments as:
Anonymous Quiz
8%
Cerebral ischemia
47%
Cardiac ischemia
24%
Hypertension
21%
Arrhythmia
MCQ NO.776 | OC
What is the product of reaction of aldehyde with K2Cr2 O7
What is the product of reaction of aldehyde with K2Cr2 O7
Anonymous Quiz
14%
Acetal
35%
Peroxyacids
30%
Acid
21%
Alcohol
MCQ NO. 777
Which of these dienes can undergo the Diels-Alder reaction?
Which of these dienes can undergo the Diels-Alder reaction?
Anonymous Quiz
44%
1,2-Butadiene
23%
1,3 Pentadiene
31%
1,4-Cyclohexadiene
2%
1,4-Pentadiene