#佐劑
#奈米脂質粒子
#高度致炎
"The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory"
https://pubmed.ncbi.nlm.nih.gov/34841223/
...
"characterized by massive neutrophil infiltration, activation of diverse inflammatory pathways, & prod. of various inflammatory cytokines & chemokines. The same dose of LNP delivered intranasally led to similar inflam. responses in the lung & resulted in a high mortality rate"
#奈米脂質粒子
#高度致炎
"The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory"
https://pubmed.ncbi.nlm.nih.gov/34841223/
...
"characterized by massive neutrophil infiltration, activation of diverse inflammatory pathways, & prod. of various inflammatory cytokines & chemokines. The same dose of LNP delivered intranasally led to similar inflam. responses in the lung & resulted in a high mortality rate"
PubMed
The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory - PubMed
Vaccines based on mRNA-containing lipid nanoparticles (LNPs) are a promising new platform used by two leading vaccines against COVID-19. Clinical trials and ongoing vaccinations present with varying degrees of protection levels and side effects. However,…
#mRNA針劑對delta變種保護效果奇差
Young-Xu Y, Zwain GM, Powell EI, Smith J. Estimated Effectiveness of COVID-19 Messenger RNA Vaccination Against SARS-CoV-2 Infection Among Older Male Veterans Health Administration Enrollees, January to September 2021. JAMA Netw Open. 2021 Dec 1;4(12):e2138975. doi: 10.1001/jamanetworkopen.2021.38975.
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2787183
Young-Xu Y, Zwain GM, Powell EI, Smith J. Estimated Effectiveness of COVID-19 Messenger RNA Vaccination Against SARS-CoV-2 Infection Among Older Male Veterans Health Administration Enrollees, January to September 2021. JAMA Netw Open. 2021 Dec 1;4(12):e2138975. doi: 10.1001/jamanetworkopen.2021.38975.
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2787183
#臨床診療指引CPG
#Covid臨床診療指引品質低落
#醫療品質低落所以合理化實驗針？
No wonder hospital care is so bad during the pandemic. Burns et al, JAMA reveals few guidelines hospitals rely upon describe benefits/risks to patients, fewer commit to expert review or updating! Use and fight medical tyranny--demand shared decision making on medical therapy!
Join 👉 @PeterMcCullough
#Covid臨床診療指引品質低落
#醫療品質低落所以合理化實驗針？
No wonder hospital care is so bad during the pandemic. Burns et al, JAMA reveals few guidelines hospitals rely upon describe benefits/risks to patients, fewer commit to expert review or updating! Use and fight medical tyranny--demand shared decision making on medical therapy!
Join 👉 @PeterMcCullough
本篇報告了四例接種後 #單側腋窩淋巴結腫大 ，此症狀最壞可能演變為惡性腫瘤，但也可能屬於良性
（本篇的定調是此症狀在 水痘、BCG、炭疽等疫苗、以及COVID實驗針劑接種後都「不算少見」，所以在懷疑淋巴瘤時要先看病人接種史，以免提高淋巴瘤的僞陽診斷率或者做過多檢查）
作者建議在此類患者接種第2劑4-12週後反覆以超音波追蹤患部，以確認康復情況
"in patients with isolated unilateral axillary adenopathy, we recommend repeat targeted ultrasound of the affected axilla 4–12 weeks after the patient's scheduled second vaccination dose to ensure resolution.
Mehta, N., Sales, R. M., Babagbemi, K., Levy, A. D., McGrath, A. L., Drotman, M., & Dodelzon, K. (2021). Unilateral axillary Adenopathy in the setting of COVID-19 vaccine. Clinical imaging, 75, 12–15. https://doi.org/10.1016/j.clinimag.2021.01.016
實證醫學頻道
https://t.me/EBSEIB
（本篇的定調是此症狀在 水痘、BCG、炭疽等疫苗、以及COVID實驗針劑接種後都「不算少見」，所以在懷疑淋巴瘤時要先看病人接種史，以免提高淋巴瘤的僞陽診斷率或者做過多檢查）
作者建議在此類患者接種第2劑4-12週後反覆以超音波追蹤患部，以確認康復情況
"in patients with isolated unilateral axillary adenopathy, we recommend repeat targeted ultrasound of the affected axilla 4–12 weeks after the patient's scheduled second vaccination dose to ensure resolution.
Mehta, N., Sales, R. M., Babagbemi, K., Levy, A. D., McGrath, A. L., Drotman, M., & Dodelzon, K. (2021). Unilateral axillary Adenopathy in the setting of COVID-19 vaccine. Clinical imaging, 75, 12–15. https://doi.org/10.1016/j.clinimag.2021.01.016
實證醫學頻道
https://t.me/EBSEIB
打越多針的，感染Omicron跟感染Delta的差距越大
"Comparing households infected with the Omicron to Delta VOC, we found an 1.17 (95%-CI: 0.99-1.38) times higher SAR for unvaccinated, 2.61 times (95%-CI: 2.34-2.90) higher for fully vaccinated and 3.66 (95%-CI: 2.65-5.05) times higher for booster-vaccinated individuals, demonstrating strong evidence of immune evasiveness of the Omicron VOC."
https://www.medrxiv.org/content/10.1101/2021.12.27.21268278v1.full
"Comparing households infected with the Omicron to Delta VOC, we found an 1.17 (95%-CI: 0.99-1.38) times higher SAR for unvaccinated, 2.61 times (95%-CI: 2.34-2.90) higher for fully vaccinated and 3.66 (95%-CI: 2.65-5.05) times higher for booster-vaccinated individuals, demonstrating strong evidence of immune evasiveness of the Omicron VOC."
https://www.medrxiv.org/content/10.1101/2021.12.27.21268278v1.full
medRxiv
SARS-CoV-2 Omicron VOC Transmission in Danish Households
The Omicron variant of concern (VOC) is a rapidly spreading variant of SARS-CoV-2 that is likely to overtake the previously dominant Delta VOC in many countries by the end of 2021.
We estimated the transmission dynamics following the spread of Omicron VOC…
We estimated the transmission dynamics following the spread of Omicron VOC…
#嗜伊性球性心肌炎
#猛爆性心肌炎
#輝瑞第一劑
#57歲女
First Identified Case of Fatal Fulminant Necrotizing Eosinophilic Myocarditis Following the Initial Dose of the Pfizer-BioNTech mRNA COVID-19 Vaccine (BNT162b2, Comirnaty): an Extremely Rare Idiosyncratic Hypersensitivity Reaction. J Clin Immunol. 2022 Jan 3. doi: 10.1007/s10875-021-01187-0. Epub ahead of print. PMID: 34978002.
“The clinical features and immunopathology of a case of fatal fulminant necrotizing eosinophilic myocarditis, following the first dose of the Pfizer-BioNTech COVID-19 vaccine, are described in this report.
It seems probable the Pfizer-BioNTech vaccine was responsible for the fatal fulminant necrotizing myocarditis in this case. The temporal association is compatible with such a hypersensitivity reaction, other causes have been excluded, and the histomorphology is consistent with the diagnosis.”
Note that this case report involved a 57 year old woman. Post-vaccination myocarditis doesn’t only happen in young men and boys.
However, despite the overwhelming worldwide data concerning the risks of myocarditis post genetic vaccination, the obsequious authors still felt it necessary to make irrational homage to the dominant approved narrative that everyone must get a vaccine was so over the top to make the article almost unreadable. Some of cited publications were very out of date and did not make the case for vaccination, in contrast to claims made by the authors.
📌 Follow and Share👇🏻
@RWMaloneMD
#猛爆性心肌炎
#輝瑞第一劑
#57歲女
First Identified Case of Fatal Fulminant Necrotizing Eosinophilic Myocarditis Following the Initial Dose of the Pfizer-BioNTech mRNA COVID-19 Vaccine (BNT162b2, Comirnaty): an Extremely Rare Idiosyncratic Hypersensitivity Reaction. J Clin Immunol. 2022 Jan 3. doi: 10.1007/s10875-021-01187-0. Epub ahead of print. PMID: 34978002.
“The clinical features and immunopathology of a case of fatal fulminant necrotizing eosinophilic myocarditis, following the first dose of the Pfizer-BioNTech COVID-19 vaccine, are described in this report.
It seems probable the Pfizer-BioNTech vaccine was responsible for the fatal fulminant necrotizing myocarditis in this case. The temporal association is compatible with such a hypersensitivity reaction, other causes have been excluded, and the histomorphology is consistent with the diagnosis.”
Note that this case report involved a 57 year old woman. Post-vaccination myocarditis doesn’t only happen in young men and boys.
However, despite the overwhelming worldwide data concerning the risks of myocarditis post genetic vaccination, the obsequious authors still felt it necessary to make irrational homage to the dominant approved narrative that everyone must get a vaccine was so over the top to make the article almost unreadable. Some of cited publications were very out of date and did not make the case for vaccination, in contrast to claims made by the authors.
📌 Follow and Share👇🏻
@RWMaloneMD
SpringerLink
First Identified Case of Fatal Fulminant Necrotizing Eosinophilic Myocarditis Following the Initial Dose of the Pfizer-BioNTech…
Journal of Clinical Immunology - Transient myopericarditis has been recognised as an uncommon and usually mild adverse event predominantly linked to mRNA-based COVID-19 vaccines. These have mostly...
#對Omicron失效
UK Technical Briefing Dec 31 2021 shows the most effective product against Delta and the legacy strains is now near zero efficacy over time against the milder and more brief Omicron strain.
Join 👉 @PeterMcCullough
UK Technical Briefing Dec 31 2021 shows the most effective product against Delta and the legacy strains is now near zero efficacy over time against the milder and more brief Omicron strain.
Join 👉 @PeterMcCullough
Forwarded from Robin Monotti + Cory Morningstar
Prion Disease Post Covid-19 Injections
Covid-19 injections induce a strong inflammatory response that can lead to brain swelling and damage to the CNS. Cells exposed to the message to make spike protein will produce exosomes loaded with microRNA. These microRNA are very strong controlling signalling molecules which will cause immune cells to produce an inflammatory response. MicroRNA gets internalised by human microglia in the brain leading to this strong inflammatory response.
Abstract :
“We propose that SARS-CoV-2 gene product, Spike, is able to modify the host exosomal cargo, which gets transported to distant uninfected tissues and organs and can initiate a catastrophic immune cascade within Central Nervous System (CNS).
SARS-CoV-2 Spike transfected cells release a significant amount of exosomes loaded with microRNAs such as miR-148a and miR-590. microRNAs gets internalized by human microglia and suppress target gene expression of USP33 (Ubiquitin Specific peptidase 33) and downstream IRF9 levels.
Cellular levels of USP33 regulate the turnover time of IRF9 via deubiquitylation.
Our results also demonstrate that absorption of modified exosomes effectively regulate the major pro-inflammatory gene expression profile of TNFα, NF-κB and IFN-β.
These results uncover a bystander pathway of SARS-CoV-2 mediated CNS damage through hyperactivation of human microglia. Our results also attempt to explain the extra-pulmonary dysfunctions observed in COVID-19 cases when active replication of virus is not supported.
Since Spike gene and mRNAs have been extensively picked up for vaccine development; the knowledge of host immune response against spike gene and protein holds a great significance.
Our study therefore provides novel and relevant insights regarding the impact of Spike gene on shuttling of host microRNAs via exosomes to trigger the neuroinflammation”
Link: https://www.frontiersin.org/articles/10.3389/fimmu.2021.656700/full
Other Related Papers Referenced by Dr Seneff:
Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses:https://pubmed.ncbi.nlm.nih.gov/29739835/
Study showing repeated exposure to antigen (foreign protein) through immunisation resulted in increased susceptibility to prion protein exposure: https://europepmc.org/article/PMC/3233904
Could Spike Protein in Moderna, Pfizer Vaccines Cause Blood Clots, Brain Inflammation and Heart Attacks?: https://childrenshealthdefense.org/defender/moderna-pfizer-vaccines-blood-clots-inflammation-brain-heart/
SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration: https://pubmed.ncbi.nlm.nih.gov/33789211/
SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro: https://pubmed.ncbi.nlm.nih.gov/34696485/
COVID-19 Vaccine Associated Parkinson’s Disease, A Prion Disease Signal in the UK Yellow Card Adverse Event Database: https://scivisionpub.com/pdfs/review-of-covid19-vaccines-and-the-risk-of-chronic-adverse-events-including-neurological-degeneration-1616.pdf
Natural helpers: “Natural polyphenols effects on protein aggregates in Alzheimer's and Parkinson's prion-like diseases”: https://pubmed.ncbi.nlm.nih.gov/29926816/
Covid-19 injections induce a strong inflammatory response that can lead to brain swelling and damage to the CNS. Cells exposed to the message to make spike protein will produce exosomes loaded with microRNA. These microRNA are very strong controlling signalling molecules which will cause immune cells to produce an inflammatory response. MicroRNA gets internalised by human microglia in the brain leading to this strong inflammatory response.
Abstract :
“We propose that SARS-CoV-2 gene product, Spike, is able to modify the host exosomal cargo, which gets transported to distant uninfected tissues and organs and can initiate a catastrophic immune cascade within Central Nervous System (CNS).
SARS-CoV-2 Spike transfected cells release a significant amount of exosomes loaded with microRNAs such as miR-148a and miR-590. microRNAs gets internalized by human microglia and suppress target gene expression of USP33 (Ubiquitin Specific peptidase 33) and downstream IRF9 levels.
Cellular levels of USP33 regulate the turnover time of IRF9 via deubiquitylation.
Our results also demonstrate that absorption of modified exosomes effectively regulate the major pro-inflammatory gene expression profile of TNFα, NF-κB and IFN-β.
These results uncover a bystander pathway of SARS-CoV-2 mediated CNS damage through hyperactivation of human microglia. Our results also attempt to explain the extra-pulmonary dysfunctions observed in COVID-19 cases when active replication of virus is not supported.
Since Spike gene and mRNAs have been extensively picked up for vaccine development; the knowledge of host immune response against spike gene and protein holds a great significance.
Our study therefore provides novel and relevant insights regarding the impact of Spike gene on shuttling of host microRNAs via exosomes to trigger the neuroinflammation”
Link: https://www.frontiersin.org/articles/10.3389/fimmu.2021.656700/full
Other Related Papers Referenced by Dr Seneff:
Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses:https://pubmed.ncbi.nlm.nih.gov/29739835/
Study showing repeated exposure to antigen (foreign protein) through immunisation resulted in increased susceptibility to prion protein exposure: https://europepmc.org/article/PMC/3233904
Could Spike Protein in Moderna, Pfizer Vaccines Cause Blood Clots, Brain Inflammation and Heart Attacks?: https://childrenshealthdefense.org/defender/moderna-pfizer-vaccines-blood-clots-inflammation-brain-heart/
SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration: https://pubmed.ncbi.nlm.nih.gov/33789211/
SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro: https://pubmed.ncbi.nlm.nih.gov/34696485/
COVID-19 Vaccine Associated Parkinson’s Disease, A Prion Disease Signal in the UK Yellow Card Adverse Event Database: https://scivisionpub.com/pdfs/review-of-covid19-vaccines-and-the-risk-of-chronic-adverse-events-including-neurological-degeneration-1616.pdf
Natural helpers: “Natural polyphenols effects on protein aggregates in Alzheimer's and Parkinson's prion-like diseases”: https://pubmed.ncbi.nlm.nih.gov/29926816/
Frontiers
Frontiers | SARS-CoV-2 Spike Targets USP33-IRF9 Axis via Exosomal miR-148a to Activate Human Microglia
SARS-CoV-2, the novel coronavirus infection has consistently shown an association with neurological anomalies in patients, in addition to its usual respirato...
#IgA血管炎
Immunoglobulin A vasculitis after #COVIDVaccination (Pfizer-BioNTech): http://www.ochsnerjournal.org/content/21/4/395
"Clinicians need to be aware that IgA vasculitis can develop in susceptible individuals following exposure to a COVID-19 vaccination."
Immunoglobulin A vasculitis after #COVIDVaccination (Pfizer-BioNTech): http://www.ochsnerjournal.org/content/21/4/395
"Clinicians need to be aware that IgA vasculitis can develop in susceptible individuals following exposure to a COVID-19 vaccination."
#GBS
#格林巴利症候群
#急性多發性神經炎
Guillain–Barré syndrome (GBS) after #COVIDVaccination (Pfizer-BioNTech): https://link.springer.com/article/10.1007%2Fs10072-021-05849-0
"The underlying pathomechanism of COVID-19 vaccine and GBS is still unclear."
#格林巴利症候群
#急性多發性神經炎
Guillain–Barré syndrome (GBS) after #COVIDVaccination (Pfizer-BioNTech): https://link.springer.com/article/10.1007%2Fs10072-021-05849-0
"The underlying pathomechanism of COVID-19 vaccine and GBS is still unclear."
#針後心肌炎實際比例遠比官方數字高
#美國CDC的篩選條件有刻意忽略
#ICD10
#電子病歷
We identified a higher estimate of myopericarditis following COVID-19 mRNA vaccine by searching encounter text description in the medical record of an integrated health system compared with the VSD methodology. The VSD specifically excluded ICD-10 code I51.4, Myocarditis, Unspecified resulting in missed episodes that met the case definition.
...
In our patients ages 12-39 years old who received a second dose of vaccine (n=146,785), we estimated a risk of 95.4 cases of myopericarditis per million second doses administered (95% CI, 52.1 to 160.0). In males who received a second dose (n=66,533) we estimated a rate of 195.4 cases of myopericarditis per million second doses (95% CI, 104.0 to 334.1).
Risk of Myopericarditis following COVID-19 mRNA vaccination in a Large Integrated Health System: A Comparison of Completeness and Timeliness of Two Methods
https://www.medrxiv.org/content/10.1101/2021.12.21.21268209v1.article-info
#美國CDC的篩選條件有刻意忽略
#ICD10
#電子病歷
We identified a higher estimate of myopericarditis following COVID-19 mRNA vaccine by searching encounter text description in the medical record of an integrated health system compared with the VSD methodology. The VSD specifically excluded ICD-10 code I51.4, Myocarditis, Unspecified resulting in missed episodes that met the case definition.
...
In our patients ages 12-39 years old who received a second dose of vaccine (n=146,785), we estimated a risk of 95.4 cases of myopericarditis per million second doses administered (95% CI, 52.1 to 160.0). In males who received a second dose (n=66,533) we estimated a rate of 195.4 cases of myopericarditis per million second doses (95% CI, 104.0 to 334.1).
Risk of Myopericarditis following COVID-19 mRNA vaccination in a Large Integrated Health System: A Comparison of Completeness and Timeliness of Two Methods
https://www.medrxiv.org/content/10.1101/2021.12.21.21268209v1.article-info
#Omicron
Omicron較不危險的原理
Omicron's feeble attack on the lungs could make it less dangerous. Kozlov M. Nature. 2022 Jan 5. doi: 10.1038/d41586-022-00007-8. Epub ahead of print. PMID: 34987210.
“Early indications from South Africa and the United Kingdom signal that the fast-spreading Omicron variant of the coronavirus SARS-CoV-2 is less dangerous than its predecessor Delta. Now, a series of laboratory studies offers a tantalizing explanation for the difference: Omicron does not infect cells deep in the lung as readily as it does those in the upper airways.”
Omicron較不危險的原理
Omicron's feeble attack on the lungs could make it less dangerous. Kozlov M. Nature. 2022 Jan 5. doi: 10.1038/d41586-022-00007-8. Epub ahead of print. PMID: 34987210.
“Early indications from South Africa and the United Kingdom signal that the fast-spreading Omicron variant of the coronavirus SARS-CoV-2 is less dangerous than its predecessor Delta. Now, a series of laboratory studies offers a tantalizing explanation for the difference: Omicron does not infect cells deep in the lung as readily as it does those in the upper airways.”
Nature
Omicron’s feeble attack on the lungs could make it less dangerous
Nature - Mounting evidence from animal studies suggests that Omicron does not multiply readily in lung tissue, which can be badly damaged in people infected with other variants.
#實驗針令COVID案例與死亡上升
#貝氏因果效應分析
#預印本
作者是加拿大UAlberta政治學博士生，研究領域為corruption，即腐敗與貪污。
The statistically significant and overwhelmingly positive causal impact after vaccine deployment on the dependent variables total deaths and total cases per million should be highly worrisome for policy makers. They indicate a marked increase in both COVID-19 related cases and death due directly to a vaccine deployment that was originally sold to the public as the “key to gain back our freedoms.” The effect of vaccines on total cases per million and its low positive association with total vaccinations per hundred signifies a limited impact of vaccines on lowering COVID-19 associated cases.
Worldwide Bayesian Causal Impact Analysis of Vaccine Administration on Deaths and Cases Associated with COVID-19: A BigData Analysis of 145 Countries
https://www.researchgate.net/publication/356248984_Worldwide_Bayesian_Causal_Impact_Analysis_of_Vaccine_Administration_on_Deaths_and_Cases_Associated_with_COVID-19_A_BigData_Analysis_of_145_Countries
#貝氏因果效應分析
#預印本
作者是加拿大UAlberta政治學博士生，研究領域為corruption，即腐敗與貪污。
The statistically significant and overwhelmingly positive causal impact after vaccine deployment on the dependent variables total deaths and total cases per million should be highly worrisome for policy makers. They indicate a marked increase in both COVID-19 related cases and death due directly to a vaccine deployment that was originally sold to the public as the “key to gain back our freedoms.” The effect of vaccines on total cases per million and its low positive association with total vaccinations per hundred signifies a limited impact of vaccines on lowering COVID-19 associated cases.
Worldwide Bayesian Causal Impact Analysis of Vaccine Administration on Deaths and Cases Associated with COVID-19: A BigData Analysis of 145 Countries
https://www.researchgate.net/publication/356248984_Worldwide_Bayesian_Causal_Impact_Analysis_of_Vaccine_Administration_on_Deaths_and_Cases_Associated_with_COVID-19_A_BigData_Analysis_of_145_Countries
ResearchGate
(PDF) Worldwide Bayesian Causal Impact Analysis of Vaccine Administration on Deaths and Cases Associated with COVID-19: A BigData…
PDF | *** THIS PAPER HAS BEEN PLACED HERE FOR PUBLIC PEER-REVIEW *** *** After public peer-review an attempt will be made for journal submission, any... | Find, read and cite all the research you need on ResearchGate
模型顯示Omicron有88%機率逃脫現行之實驗性針劑
Omicron Variant (B.1.1.529): Infectivity, Vaccine Breakthrough, and Antibody Resistance. J Chem Inf Model. 2022 Jan 6. doi: 10.1021/acs.jcim.1c01451. Epub ahead of print. PMID: 34989238.
Abstract
“…Here, we present a comprehensive quantitative analysis of Omicron's infectivity, vaccine breakthrough, and antibody resistance. An artificial intelligence (AI) model, which has been trained with tens of thousands of experimental data and extensively validated by experimental results on SARS-CoV-2, reveals that Omicron may be over 10 times more contagious than the original virus or about 2.8 times as infectious as the Delta variant. On the basis of 185 three-dimensional (3D) structures of antibody-RBD complexes, we unveil that Omicron may have an 88% likelihood to escape current vaccines.
…However, its impacts on GlaxoSmithKline's sotrovimab appear to be mild.”
Importance:
Based on modeling, the Omicron may have an 88% likelihood to escape current vaccines.
Do I need to write more?
📌 Follow and Share👇🏻
@RWMaloneMD
Omicron Variant (B.1.1.529): Infectivity, Vaccine Breakthrough, and Antibody Resistance. J Chem Inf Model. 2022 Jan 6. doi: 10.1021/acs.jcim.1c01451. Epub ahead of print. PMID: 34989238.
Abstract
“…Here, we present a comprehensive quantitative analysis of Omicron's infectivity, vaccine breakthrough, and antibody resistance. An artificial intelligence (AI) model, which has been trained with tens of thousands of experimental data and extensively validated by experimental results on SARS-CoV-2, reveals that Omicron may be over 10 times more contagious than the original virus or about 2.8 times as infectious as the Delta variant. On the basis of 185 three-dimensional (3D) structures of antibody-RBD complexes, we unveil that Omicron may have an 88% likelihood to escape current vaccines.
…However, its impacts on GlaxoSmithKline's sotrovimab appear to be mild.”
Importance:
Based on modeling, the Omicron may have an 88% likelihood to escape current vaccines.
Do I need to write more?
📌 Follow and Share👇🏻
@RWMaloneMD
ACS Publications
Omicron Variant (B.1.1.529): Infectivity, Vaccine Breakthrough, and Antibody Resistance
The latest severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant Omicron (B.1.1.529) has ushered panic responses around the world due to its contagious and vaccine escape mutations. The essential infectivity and antibody resistance of the SARS…
#Moderna 第一劑後自體免疫肝炎
Immune-mediated hepatitis with the Moderna vaccine, no longer a coincidence but confirmed
“Our case demonstrates conclusive evidence of vaccine-induced immune-mediated hepatitis with a rapid onset of liver injury after the first Moderna dose, which on re-exposure led to acute severe autoimmune hepatitis.”
https://www.journal-of-hepatology.eu/article/S0168-8278(21)02093-6/fulltext
@ChiefNerd
Immune-mediated hepatitis with the Moderna vaccine, no longer a coincidence but confirmed
“Our case demonstrates conclusive evidence of vaccine-induced immune-mediated hepatitis with a rapid onset of liver injury after the first Moderna dose, which on re-exposure led to acute severe autoimmune hepatitis.”
https://www.journal-of-hepatology.eu/article/S0168-8278(21)02093-6/fulltext
@ChiefNerd
#實驗針對防疫沒用
#NNE
本傳染病學論文，概念比較不日常，需要解釋：
1.防止傳染病擴散的方法很多，施打有效的疫苗是其中一種
2.有一個專有名詞跟概念叫Number needed to exclude (NNE) ，意為把多少個沒吃藥的人從人群中移除，才能讓沒吃藥的人不會把病傳染下去。
3.NNE越高，代表你這個藥越沒用。NNE跟ARR（絕對保護力）是倒數關係。
4.本研究發現你需要減少1000個未施打實驗針的人，才相當於減少1個SARS-CoV-2的感染案例
5.本論文結論指出，排除沒打實驗針的人（意即 讓沒打實驗針的群體人數變少，讓他們屬於已打實驗針群體）對防疫沒用。
Evaluating the number of unvaccinated people needed to exclude to prevent SARS-CoV-2 transmissions
https://www.medrxiv.org/content/10.1101/2021.12.08.21267162v1
“The NNEs suggest that at least 1,000 unvaccinated people likely need to be excluded to prevent one SARS-CoV-2 transmission event in most types of settings.
Vaccines are beneficial, but the high NNEs suggest that excluding unvaccinated people has negligible benefits for reducing transmissions in many jurisdictions across the globe.”
#NNE
本傳染病學論文，概念比較不日常，需要解釋：
1.防止傳染病擴散的方法很多，施打有效的疫苗是其中一種
2.有一個專有名詞跟概念叫Number needed to exclude (NNE) ，意為把多少個沒吃藥的人從人群中移除，才能讓沒吃藥的人不會把病傳染下去。
3.NNE越高，代表你這個藥越沒用。NNE跟ARR（絕對保護力）是倒數關係。
4.本研究發現你需要減少1000個未施打實驗針的人，才相當於減少1個SARS-CoV-2的感染案例
5.本論文結論指出，排除沒打實驗針的人（意即 讓沒打實驗針的群體人數變少，讓他們屬於已打實驗針群體）對防疫沒用。
Evaluating the number of unvaccinated people needed to exclude to prevent SARS-CoV-2 transmissions
https://www.medrxiv.org/content/10.1101/2021.12.08.21267162v1
“The NNEs suggest that at least 1,000 unvaccinated people likely need to be excluded to prevent one SARS-CoV-2 transmission event in most types of settings.
Vaccines are beneficial, but the high NNEs suggest that excluding unvaccinated people has negligible benefits for reducing transmissions in many jurisdictions across the globe.”