4 cases of of cytokine storm after #covidvaccination: https://www.frontiersin.org/articles/10.3389/fimmu.2022.967226/full
All 4 patients died.
"390 genes were found to be upregulated and 115 genes were downregulated in post-vaccination cases compared with controls."
"Our results suggest that immune dysregulation occurred following vaccination."
All 4 patients died.
"390 genes were found to be upregulated and 115 genes were downregulated in post-vaccination cases compared with controls."
"Our results suggest that immune dysregulation occurred following vaccination."
A case of thrombotic thrombocytopenia after #covidvaccination: https://www.cureus.com/articles/98603-a-case-of-covid-19-vaccine-induced-thrombotic-thrombocytopenia
A 37-year-old woman.
"... the patient was found to have a right common femoral artery embolus, left distal popliteal trifurcation embolism, a small pulmonary embolism in the right lower lobe, and a mural thrombus of the infrarenal abdominal aorta"
A 37-year-old woman.
"... the patient was found to have a right common femoral artery embolus, left distal popliteal trifurcation embolism, a small pulmonary embolism in the right lower lobe, and a mural thrombus of the infrarenal abdominal aorta"
Important finding:
#Covidvaccination can induce autoantibodies against type I
interferons: https://www.sciencedirect.com/science/article/pii/S0896841122001044?via%3Dihub
The immune system attacks itself.
"It has become increasingly apparent that innate immunity is critical for the induction of virus-specific adaptive immune responses [14]. Thus, the type I IFN innate-mediated immune responses can be double-edged swords in enhancing vaccine efficacy and immune responses to acute infectious diseases, as well as accelerating chronic disease pathogenesis (e.g., chronic viral infections, cancer, and autoimmune diseases). This case highlights BNT162b2-induced neutralizing anti-type I IFN autoantibodies, which may affect vaccine efficacy or chronic disease pathogenesis in some patients and deserves further investigations."
#Covidvaccination can induce autoantibodies against type I
interferons: https://www.sciencedirect.com/science/article/pii/S0896841122001044?via%3Dihub
The immune system attacks itself.
"It has become increasingly apparent that innate immunity is critical for the induction of virus-specific adaptive immune responses [14]. Thus, the type I IFN innate-mediated immune responses can be double-edged swords in enhancing vaccine efficacy and immune responses to acute infectious diseases, as well as accelerating chronic disease pathogenesis (e.g., chronic viral infections, cancer, and autoimmune diseases). This case highlights BNT162b2-induced neutralizing anti-type I IFN autoantibodies, which may affect vaccine efficacy or chronic disease pathogenesis in some patients and deserves further investigations."
5 cases of new-onset pemphigus following #Covidvaccination: https://onlinelibrary.wiley.com/doi/10.1111/1346-8138.16554
" ... physicians should be aware of the possibility of autoimmune blistering diseases following SARS-CoV-2 vaccine ..."
" ... physicians should be aware of the possibility of autoimmune blistering diseases following SARS-CoV-2 vaccine ..."
Pemphigus foliaceus after #Covidvaccination:
https://onlinelibrary.wiley.com/doi/10.1111/dth.15775
" ... further research is needed to identify individuals at risk of developing autoimmunity following vaccination."
https://onlinelibrary.wiley.com/doi/10.1111/dth.15775
" ... further research is needed to identify individuals at risk of developing autoimmunity following vaccination."
New onset pemphigus foliaceus following AstraZeneca #Covidvaccination:
https://onlinelibrary.wiley.com/doi/10.1111/jdv.18484
"A 62-year-old woman in good health with no significant past medical history and no previous skin disease developed a generalized erythematous itchy rash 1 week after the first dose of AstraZeneca COVID-19 vaccination. Administration of the second dose of the same vaccine 12 weeks later resulted in significant skin worsening within 2 days, with extensive scaling and erythema."
https://onlinelibrary.wiley.com/doi/10.1111/jdv.18484
"A 62-year-old woman in good health with no significant past medical history and no previous skin disease developed a generalized erythematous itchy rash 1 week after the first dose of AstraZeneca COVID-19 vaccination. Administration of the second dose of the same vaccine 12 weeks later resulted in significant skin worsening within 2 days, with extensive scaling and erythema."
Nattokinase (an enzyme) is able to degrade the SARS-CoV-2 spike protein in a dose-dependent manner: https://www.mdpi.com/1420-3049/27/17/5405
The intake might be helpful to dissolve the blood cloths (microclots [& white fibrous clots ?]) in #COVID19, #LongCovid and after #covidvaccination.
More information: https://pharmd.substack.com/p/frequency-asked-questions-nattokinase
The intake might be helpful to dissolve the blood cloths (microclots [& white fibrous clots ?]) in #COVID19, #LongCovid and after #covidvaccination.
More information: https://pharmd.substack.com/p/frequency-asked-questions-nattokinase
(2/2)
Interestingly, when the anti-SARS-CoV-2 S1 pathogenic antibodies are mixed with anti-SARS-CoV-2 N antibodies, ADAA is diminished.
Since #Covidvaccination induces anti-SARS-CoV-2 S antibodies, the probability of ADAA will be higher compared to a natural SARS-CoV-2 infection.
Interestingly, when the anti-SARS-CoV-2 S1 pathogenic antibodies are mixed with anti-SARS-CoV-2 N antibodies, ADAA is diminished.
Since #Covidvaccination induces anti-SARS-CoV-2 S antibodies, the probability of ADAA will be higher compared to a natural SARS-CoV-2 infection.
Case of a 53-year-old immunosuppressed (due to rheumatoid arthritis treatment) man.
2 days after the 2nd #Covidvaccination:
Fulminant inflammation & demyelination in the brain and spinal cord.
He died.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784396/
2 days after the 2nd #Covidvaccination:
Fulminant inflammation & demyelination in the brain and spinal cord.
He died.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784396/
A 67-year-old woman.
2 days after #Covidvaccination: right-sided hemiparesis & neck pain with rapid deterioration to a deep coma. Diagnosis: extensive cervicothoracic hematomyelia.
https://onlinelibrary.wiley.com/doi/10.1002/ccr3.6743
2 days after #Covidvaccination: right-sided hemiparesis & neck pain with rapid deterioration to a deep coma. Diagnosis: extensive cervicothoracic hematomyelia.
https://onlinelibrary.wiley.com/doi/10.1002/ccr3.6743
Good summary by Jessica Rose of the important findings of Irrgang et al. (https://www.science.org/doi/10.1126/sciimmunol.ade2798) regarding the unusual (and worrying) IgG4 antobody increase in individuals after #Covidvaccination (Pfizer-BioNTech):
https://jessicar.substack.com/p/the-immunological-mechanism-of-action
https://jessicar.substack.com/p/the-immunological-mechanism-of-action
Science Immunology
Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination
Repeated SARS-CoV-2 mRNA vaccinations shift the antibody response toward IgG4 subclass with decreased FcγR-dependent effector activity.
Acute disseminated encephalomyelitis after #Covidvaccination: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788800/
She died.
She died.
Relapsing anti-MOG antibody-associated disease following #Covidvaccination: https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_0504-22/_article
"A healthy 23-year-old woman presented with vertigo,
vomiting, and headache from the 33rd day after receiving the 2nd dose of the BNT162b2 vaccine."
"A healthy 23-year-old woman presented with vertigo,
vomiting, and headache from the 33rd day after receiving the 2nd dose of the BNT162b2 vaccine."