دکتر امیر محمد شهسوارانی
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مرور سیستماتیک استرس و بررسی سازه ها و عوامل دخیل در آن

#Stress: #Facts and #Theories through #Literature #Review

#Amir_Mohammad_Shahsavarani, #Esfandiar_Azad_Marz_Abadi, #Maryam_Hakimi_Kalkhoran

Abstract
Introduction: #Human everyday life is full of #stress and strain, so that the present century is called stress era. Unfortunately, here is no literature integration about stress. The aim of the present paper is to make a theoretical integrative consensus in stress modalities.

Methods: The design of the present study was #systematic #review. #Inclusion #criteria were subjective relevance to study keywords (include #stress, #stress_control, #stress_reduction, #social_stress, #community_stress, #group_stress, #stress_increase, #stress_side_effects, #stress_resources, #stress_stages, #stress_types), being published by academic and/or scientific resource, and publication period (between January, 1, 1990 and March, 20, 2015). Using Jadad scale, those clinical trial papers with 2 and upper were selected. #Delphi_method used to form the structure of final results. Results were collected by content analysis.

Results: Eleven major definitions, three main classifications, three fundamental #explanatory perspectives, #occupational stress and related issues, #job #burnout and related issues, biological and #neuropsychological bases, related constructs (#anxiety, #homeostasis, #allostasis), #spiritual/religious/Islamic perspectives, stress outcomes, and multiple relations between stress and culture were presented and discussed.

Conclusion: The ppresent study was an effort to make a theoretical unity of thought in studies about stress. According to the results, it appears that stress cannot be investigated via unimodal studies, and there is a great need to incorporate #BioPsychoSocioSpiritual perspective in analyses and future frameworks of stress studies.

Keywords:
#Stress, #Hypothalamus-Pituitary-Adrenal (HPA) axis, #Homeostasis, #Allostasis, #Cultural stress, BioPsychoSocioSpiritual model, Systematic Review, #Jadad Method, #Delphi Method.

کانال دکتر امیر محمد شهسوارانی

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@DrAmirMohammadShahsavarani


[download link]
http://journals.bmsu.ac.ir/ijmr/index.php/ijmr/article/view/107
Abstract
Sleep, a mysterious #behavior, has recently been recognized as a crucial factor for #health and #longevity. The daily sleep/wake #cycle provides the basis of #biorhythms controlling whole-body #homeostasis and #homeodynamics; therefore, #disruption of sleep causes several #physical and #psychological disorders, including #cardiovascular disease, #obesity, #diabetes, #cancer, #anxiety, #depression, and #cognitive #dysfunction. However, the mechanism linking sleep disturbances and sleep-related disorders remains unknown. #Orexin (also known as #hypocretin) is a #neuropeptide produced in the #hypothalamus. Central levels of orexin #oscillate with the #daily #rhythm and #peak at the #awake phase. Orexin plays a major role in #stabilizing the #wakefulness state. Orexin deficiency causes sleep/wake-state instability, resulting in #narcolepsy. Hyper-activation of the orexin system also causes sleep disturbances, such as #insomnia, and hence, #suvorexant, an orexin #receptor #antagonist, has been clinically used to treat insomnia. Importantly, central actions of orexin regulate #motivated behaviors, #stress response, and #energy/glucose #metabolism by coordinating the central-#autonomic #nervous systems and #endocrine systems. These multiple actions of orexin maintain #survival. However, it remains unknown whether chronopharmacological interventions targeting the orexin system ameliorate sleep-related disorders as well as sleep in humans. To understand the significance of adequate orexin action for #prevention of these disorders, this review summarizes the #physiological functions of daily orexin action and #pathological implications of its mistimed or reduced action in sleep disturbances and sleep-related disorders (#lifestyle-related physical and #neurological disorders in particular). Timed administration of drugs targeting the orexin system may prevent lifestyle-related diseases by improving the #quality of #life (#QOL) in #patients with sleep disturbances.

لینک منبع پیشنهادی برای مطالعه بیشتر 👇🏻(further reading)👇🏻
https://doi.org/10.1016/j.pharmthera.2017.12.010

(در صورت جذابیت و علاقمندی به موضوع، مطلب را برای دیگران نیز بازنشر فرمایید).

📢کانال #دکترامیرمحمدشهسوارانی
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@DrAmirMohammadShahsavarani